EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
    2.7.1.91 | 0.0000017 |
- |
[(2R)-1-([4-[(3-cyclohexylphenoxy)methyl]phenyl]methyl)pyrrolidin-2-yl]methanol |
IC50 below 0.0000017 mM, isoform SphK1, at pH 8.0 and 25°C |
761036 |
| 2.7.1.91 | 0.0000017 |
- |
[(2R)-1-([4-[(3-cyclohexylphenoxy)methyl]phenyl]methyl)pyrrolidin-2-yl]methanol |
IC50 below 0.0000017 mM, isoform SphK2, at pH 8.0 and 25°C |
761036, 761682 |
| 2.7.1.91 | 0.0000036 |
- |
PF-543 |
isoform SphK1, at pH 8.0 and 25°C |
761036 |
| 2.7.1.91 | 0.000016 |
- |
PF-543 |
at pH 7.4 and 37°C |
760683 |
| 2.7.1.91 | 0.00002 |
- |
(2R,4S)-2-(hydroxymethyl)-1-[2-[4-([4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]ethyl]piperidin-4-ol |
isoform SphK2, pH and temperature not specified in the publication |
760267 |
| 2.7.1.91 | 0.00002 |
- |
Amgen 23 |
isoform SphK1, at pH 8.0 and 25°C |
761036 |
| 2.7.1.91 | 0.000048 |
- |
SLP7111228 |
isoform SphK1, at pH 8.0 and 25°C |
761036 |
| 2.7.1.91 | 0.00005 |
- |
(2S)-2-amino-N-(4-octylphenyl)-4-hydroxybutanamide |
pH 7.5, 22°C |
702597 |
| 2.7.1.91 | 0.000062 |
- |
(2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-carboxamide |
pH 7.5, 22°C |
702597 |
| 2.7.1.91 | 0.00016 |
- |
Amgen 23 |
isoform SphK2, at pH 8.0 and 25°C |
761036 |
