Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3S)-2-[[(4-octylphenyl)amino]methyl]pyrrolidin-3-ol | inhibition of isoform Sk1 | Homo sapiens | |
(2S)-2-amino-N-(4-octylphenyl)-4-hydroxybutanamide | inhibition of isoform Sk1 | Homo sapiens | |
(2S,3R)-2-amino-N-(4-octylphenyl)-3-hydroxybutanamide | inhibition of isoform Sk1 | Homo sapiens | |
(2S,3S)-3-hydroxy-N-(4-octylbenzyl)pyrrolidine-2-carboxamide | inhibition of isoform Sk1 | Homo sapiens | |
(2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-carboxamide | inhibition of isoform Sk1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + fluorescein-labeled sphingosine | - |
Homo sapiens | ADP + fluorescein-labeled sphingosine 1-phosphate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH 7.5, 22°C | Homo sapiens | (2S)-2-amino-N-(4-octylphenyl)-4-hydroxybutanamide | |
0.000062 | - |
pH 7.5, 22°C | Homo sapiens | (2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-carboxamide | |
0.00043 | - |
pH 7.5, 22°C | Homo sapiens | (2S,3S)-3-hydroxy-N-(4-octylbenzyl)pyrrolidine-2-carboxamide | |
0.00065 | - |
pH 7.5, 22°C | Homo sapiens | (2S,3R)-2-amino-N-(4-octylphenyl)-3-hydroxybutanamide | |
0.00074 | - |
pH 7.5, 22°C | Homo sapiens | (2R,3S)-2-[[(4-octylphenyl)amino]methyl]pyrrolidin-3-ol |