EC Number |
Cofactor |
Reference |
---|
2.3.1.37 | pyridoxal 5'-phosphate |
- |
486808, 486810, 486812, 486813, 486814, 486815, 486816, 486817, 486818, 486820, 486821, 486822, 486823, 486824, 486827, 486828, 486829, 486830, 486831, 486833, 486834, 486836, 486837, 486838, 486840, 486841, 486842, 486843, 486845, 486846, 486847, 486848, 486850, 486851, 486852, 486859, 661787, 718696, 719402, 719419, 719861, 720074, 756091, 756100, 756270, 756455, 756863, 756992, 757255, 757560, 757676, 757677, 757686, 758234, 758299, 758425 |
2.3.1.37 | pyridoxal 5'-phosphate |
1 or 2 molecules of cofactor are bound per subunit of MW 50000 in hemiapoenzyme or holoenzyme, required |
486826 |
2.3.1.37 | pyridoxal 5'-phosphate |
absolute requirement |
486811 |
2.3.1.37 | pyridoxal 5'-phosphate |
activates |
486809 |
2.3.1.37 | pyridoxal 5'-phosphate |
bound to the enzyme through a Schiff base linkage |
486820, 486825 |
2.3.1.37 | pyridoxal 5'-phosphate |
contains 1 molar equivalent of pyridoxal 5'-phosphate |
486844 |
2.3.1.37 | pyridoxal 5'-phosphate |
content in ALAS-E wild-type and Lys313 mutants |
486849 |
2.3.1.37 | pyridoxal 5'-phosphate |
dependent on |
677263, 735711, 736116, 736454, 736491, 755944 |
2.3.1.37 | pyridoxal 5'-phosphate |
dependent on, succinyl-CoA binding effects the cofactor-binding site of wild-type and mutant enzymes and induces distinct changes to the chiral environment of the cofactor, overview |
735684 |
2.3.1.37 | pyridoxal 5'-phosphate |
dependent on, wild-type Km is 0.0000215 nM, Km values of mutant enzymes are between 0.0000062 nM and 0.00065 nM |
736819 |