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succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
covalent binding of pyridoxal 5'-phosphate and glycine to active site Lys131 is required for optimal activity
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
Tyr121, Asp279, Arg439, and Lys313 are involved in substrate and cofactor binding, mechanism, subunit localisation
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
cysteine in heme-regulatory motif
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
Lys313 acts as a general base during formation of the quinonoid reaction intermediates
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
the active site is located at the subunit interface and contains catalytically essential residues from the two subunits
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
the active site is located at the subunit interface and contains catalytically essential residues from the two subunits
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
three-step kinetic process, ordered kinetic mechanism, reaction mechanism
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
pyridoxal 5'-phosphate binding site, sequence and function of glycine-rich motif
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism, aldimine linkage between pyridoxal 5-phosphate and enzyme
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathans hypothesis
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
proposed chemical mechanism of enzyme ALAS2 via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycine-succinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
proposed chemical mechanism of enzyme ALAS2. via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycinesuccinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
the rate of 5-aminolevulinate release is controlled by a hysteretic kinetic mechanism initiated by conformational changes of the enzyme. The active site residue Thr148 modulates the enzyme's strict amino acid substrate specificity. Catalytic mechanism, overview
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism, aldimine linkage between pyridoxal 5-phosphate and enzyme
-
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
-
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last
-
-
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
-
-
-
-
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2-hydroxybutanoyl-CoA + glycine
? + CoA + CO2
-
-
-
-
?
5-aminolevulinate-CoA
2-amino-3-hydroxycyclopent-2-en-1-one + CoASH
-
weak cyclization activity
-
-
-
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
butanoyl-CoA + glycine
? + CoA + CO2
-
-
-
-
?
butyryl-CoA + glycine
?
-
low activity
-
-
?
glutaryl-CoA + glycine
? + CoA + CO2
-
-
-
-
?
octanoyl-CoA + glycine
? + CoA + CO2
-
-
-
-
?
propionyl-CoA + glycine
?
-
low activity
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
succinyl-CoA + L-serine
?
the reaction with L-serine follows a biphasic kinetic process
-
-
?
succinyl-CoA + O-methylglycine
?
-
-
-
?
succinyl-CoA-monomethyl ester + glycine
5-aminolevulinic acid methyl ester + CoA + CO2
additional information
?
-
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
low activity
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
acetyl-CoA + glycine
?
-
at 2% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
alpha-glutamyl-CoA + glycine
6-amino-5-oxohexanoate + CoA + CO2
-
at 9% the rate of the reaction with succinyl-CoA
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for glycine
-
ir
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
key enzyme in tetrapyrrole biosynthesis
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
rate-limiting enzyme of heme biosynthesis
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for glycine
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for glycine
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for glycine
-
ir
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for succinyl-CoA
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
enzyme utilizes acetyl-CoA, propionyl-CoA and butyryl-CoA at much lower rates
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
glycine is formed by the reverse reaction under optimum conditions at 4-5% the rate of 5-aminolevulinate formed by the forward reaction under optimum conditions
-
r
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolutely specific for glycine
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
key enzyme in tetrapyrrole biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
regulatory mechanisms in hepatic and erythroid cells
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
rate-limiting enzyme of heme biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolutely specific for glycine
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for glycine
-
ir
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolutely specific for glycine
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
key enzyme in tetrapyrrole biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
key enzyme in tetrapyrrole biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
regulatory mechanisms in hepatic and erythroid cells
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
rate-limiting enzyme of heme biosynthesis
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
rate-limiting enzyme of heme biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
r
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolute requirement for glycine
-
ir
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
absolutely specific for glycine
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
key enzyme in tetrapyrrole biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
key enzyme in tetrapyrrole biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
regulatory mechanisms in hepatic and erythroid cells
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
rate-limiting enzyme of heme biosynthesis
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
rate-limiting enzyme of heme biosynthesis
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
ALAS2 synthesizes heme specifically for haemoglobin
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
first and rate-limiting step of heme biosynthesis. Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
-
-
-
?
succinyl-CoA + glycine
5-aminolevulinate + CoA + CO2
2.3.1.37 5-aminolevulinate synthase
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