Information on EC 2.3.1.37 - 5-aminolevulinate synthase

Reaction Schemes

hideshow

succinyl-CoA

+

glycine

=

5-aminolevulinate

+

CoA

+

CO2

+

=

+

+

Synonyms
alas2, ala synthase, 5-aminolevulinate synthase, ala-s, delta-aminolevulinate synthase, delta-aminolevulinic acid synthase, delta-aminolevulinic acid synthetase, 5-aminolevulinic acid synthase, aminolevulinate synthase, delta-aminolevulinate synthetase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5-ALA synthase

Rattus norvegicus

-

-

757560

5-ALAS

Rattus norvegicus

-

-

757560

5-aminolevulinate synthase

4 entries

5-aminolevulinate synthetase

-

-

-

-

5-aminolevulinic acid synthase

6 entries

5-aminolevulinic acid synthetase

-

-

-

-

ALA

Acidipropionibacterium acidipropionici

-

-

720074

ALA synthase

9 entries

ALA synthetase

-

-

-

-

ALA-S

4 entries

ALAS

17 entries

ALAS2

5 entries

alpha-aminolevulinic acid synthase

-

-

-

-

aminolevulinate synthase

-

-

-

-

aminolevulinate synthase 2

Xenopus laevis

Q68F30

-

735604

aminolevulinate synthetase

-

-

-

-

aminolevulinic acid synthase

2 entries

aminolevulinic acid synthase 2

Homo sapiens

P22557

-

757677

aminolevulinic acid synthetase

-

-

-

-

aminolevulinic synthetase

-

-

-

-

delta-ALAS

Rattus norvegicus

-

-

486858

delta-aminolevulinate synthase

4 entries

delta-aminolevulinate synthetase

-

-

-

-

delta-aminolevulinic acid synthase

-

-

-

-

delta-aminolevulinic acid synthase 2

Homo sapiens

P22557

-

757677

delta-aminolevulinic acid synthetase

-

-

-

-

delta-aminolevulinic synthetase

-

-

-

-

erythroid 5-aminolevulinate synthase

Mus musculus

P08680

-

736116

erythroid-specific 5-aminolevulinate synthase

Homo sapiens

P22557

-

736819

Hem1

Saccharomyces cerevisiae

P09950

-

758491

hemA

8 entries

HemT

3 entries

mALAS-2

Mus musculus

-

mature form of the murine erythroid specific isoform of aminolevulinate synthase

687586

sigma-aminolevulinate synthase

3 entries

synthase, aminolevulinate

-

-

-

-

synthetase, aminolevulinate

-

-

-

-

5-aminolevulinate synthase

Acidipropionibacterium acidipropionici

-

-

720074

5-aminolevulinate synthase

Homo sapiens

-

-

719419

5-aminolevulinate synthase

Mus musculus

-

-

718696

5-aminolevulinate synthase

Mus musculus

P08680

-

737145

5-aminolevulinic acid synthase

Cereibacter sphaeroides

Q04512

-

757686

5-aminolevulinic acid synthase

Cereibacter sphaeroides ATCC17023

Q04512

-

-

5-aminolevulinic acid synthase

Cereibacter sphaeroides ATCC17025

-

-

-

5-aminolevulinic acid synthase

Cereibacter sphaeroides ATCC17029

-

-

-

5-aminolevulinic acid synthase

Rhodobacter capsulatus

-

-

756455

5-aminolevulinic acid synthase

Saccharomyces cerevisiae

P09950

-

758491

ALA synthase

-

-

-

-

ALA synthase

Cereibacter sphaeroides

-

-

757686, 758299

ALA synthase

Cereibacter sphaeroides

Q04512

-

757686

ALA synthase

Cereibacter sphaeroides ATCC17023

Q04512

-

-

ALA synthase

Cereibacter sphaeroides ATCC17025

-

-

-

ALA synthase

Cereibacter sphaeroides ATCC17029

-

-

-

ALA synthase

Rattus norvegicus

-

-

677945

ALA synthase

Rattus norvegicus Sprague-Dawley

-

-

-

ALA synthase

Rhodopseudomonas palustris

-

-

756270

ALA-S

Homo sapiens

-

-

688761

ALA-S

Mus musculus

-

-

672997

ALA-S

Rattus norvegicus

-

-

688761

ALA-S

Saccharomyces cerevisiae

-

-

486854

ALAS

-

-

-

-

ALAS

Caulobacter vibrioides

Q9A8J8

-

758425

ALAS

Caulobacter vibrioides CB15

Q9A8J8

-

-

ALAS

Drosophila melanogaster

-

-

719402

ALAS

Escherichia coli

-

-

719861

ALAS

Homo sapiens

-

-

758234

ALAS

Homo sapiens

P22557

-

735684

ALAS

Mus musculus

-

-

718696

ALAS

Mus musculus

P08680

-

737145

ALAS

Penaeus vannamei

-

-

756863

ALAS

Rattus norvegicus

-

-

677945

ALAS

Rattus norvegicus Sprague-Dawley

-

-

-

ALAS

Rhodobacter capsulatus

-

-

756455

ALAS

Rhodobacter capsulatus

P18079

-

757255

ALAS

Rhodobacter capsulatus ATCC BAA-309

P18079

-

-

ALAS

Rhodopseudomonas palustris

-

-

756270

ALAS

Saccharomyces cerevisiae

P09950

-

758491

ALAS2

Homo sapiens

-

-

671812, 718890, 719419

ALAS2

Homo sapiens

P22557

-

685795, 736819, 756091, 757677

ALAS2

Mus musculus

P08680

-

735711, 736116, 736491, 755944, 757255, 757676

ALAS2

Mus musculus

P08680

isoform

756100, 756992

ALAS2

Xenopus laevis

Q68F30

-

735604

aminolevulinic acid synthase

-

-

-

-

aminolevulinic acid synthase

Penaeus vannamei

-

-

756863

delta-aminolevulinate synthase

-

-

-

-

delta-aminolevulinate synthase

Homo sapiens

-

-

758234

delta-aminolevulinate synthase

Rattus norvegicus

-

-

677945

delta-aminolevulinate synthase

Rattus norvegicus Sprague-Dawley

-

-

-

hemA

Cereibacter sphaeroides

-

-

758299

hemA

Cereibacter sphaeroides

Q04512

isoform

757686

hemA

Cereibacter sphaeroides ATCC17023

Q04512

isoform

-

hemA

Cereibacter sphaeroides ATCC17025

-

isoform

-

hemA

Cereibacter sphaeroides ATCC17029

-

isoform

-

hemA

Rhodobacter capsulatus

P18079

-

757255

hemA

Rhodobacter capsulatus ATCC BAA-309

P18079

-

-

hemA

Rhodopseudomonas palustris

-

-

705080

HemT

Cereibacter sphaeroides

-

isoform

757686

HemT

Cereibacter sphaeroides ATCC17025

-

isoform

-

HemT

Cereibacter sphaeroides ATCC17029

-

isoform

-

sigma-aminolevulinate synthase

Drosophila melanogaster

-

-

719402

sigma-aminolevulinate synthase

Escherichia coli

-

-

719861

sigma-aminolevulinate synthase

Homo sapiens

-

-

718890

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

31 entries

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Gallus gallus

-

486820, 486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Cavia porcellus

-

486820

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Paracoccus denitrificans

-

486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Mus musculus

-

486850, 486859

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Homo sapiens

-

486820, 486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Rattus norvegicus

-

486813, 486820, 486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Saccharomyces cerevisiae

-

486820, 486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Oryctolagus cuniculus

-

486820

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Euglena gracilis

-

486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Cereibacter sphaeroides

-

486819, 486820, 486821, 486826, 486845, 486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Spinacia oleracea

-

486820

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Propionibacterium freudenreichii subsp. shermanii

-

486820

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Rhodospirillum rubrum

-

486820

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

covalent binding of pyridoxal 5'-phosphate and glycine to active site Lys131 is required for optimal activity

Mus musculus

-

486849

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

Tyr121, Asp279, Arg439, and Lys313 are involved in substrate and cofactor binding, mechanism, subunit localisation

Mus musculus

-

486849, 486851, 486852, 486855, 486856, 486857

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

cysteine in heme-regulatory motif

Mus musculus

-

486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

Lys313 acts as a general base during formation of the quinonoid reaction intermediates

Mus musculus

-

486859

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

the active site is located at the subunit interface and contains catalytically essential residues from the two subunits

Mus musculus

-

486852

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

the active site is located at the subunit interface and contains catalytically essential residues from the two subunits

Saccharomyces cerevisiae

-

486852

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

three-step kinetic process, ordered kinetic mechanism, reaction mechanism

Mus musculus

-

486861

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

pyridoxal 5'-phosphate binding site, sequence and function of glycine-rich motif

Mus musculus

-

486850, 486851

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last

Cereibacter sphaeroides

-

486845, 486850

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism, aldimine linkage between pyridoxal 5’-phosphate and enzyme

Rhodopseudomonas palustris

Q6RVB3

661787

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathan’s hypothesis

Mus musculus

-

687586

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

proposed chemical mechanism of enzyme ALAS2 via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycine-succinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine

Mus musculus

P08680

736491

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

proposed chemical mechanism of enzyme ALAS2. via (I) internal aldimine complex, (II) glycine-external aldimine, (III) quinonoid intermediate I, (IV) glycine–succinyl-CoA condensation intermediate, (V) 2-amino-3-ketoadipate intermediate, (VI) enol intermediate, (VII) quinonoid intermediate II, and (VIII) 5-aminolevulinate-external aldimine

Mus musculus

P08680

736116

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

the rate of 5-aminolevulinate release is controlled by a hysteretic kinetic mechanism initiated by conformational changes of the enzyme. The active site residue Thr148 modulates the enzyme's strict amino acid substrate specificity. Catalytic mechanism, overview

Mus musculus

P08680

736454

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism, aldimine linkage between pyridoxal 5’-phosphate and enzyme

Rhodopseudomonas palustris KUGB306

-

-

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

mechanism

Cereibacter sphaeroides Y

-

-

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last

Cereibacter sphaeroides Y

-

-

succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Acyl group transfer

-

-

-

-

condensation

12 entries

condensation

Gallus gallus

-

-

486820

condensation

Cavia porcellus

-

-

486820

condensation

Mus musculus

-

-

486856

condensation

Homo sapiens

-

-

486820

condensation

Rattus norvegicus

-

-

486820

condensation

Saccharomyces cerevisiae

-

-

486820

condensation

Oryctolagus cuniculus

-

-

486820

condensation

Cereibacter sphaeroides

-

-

486820

condensation

Spinacia oleracea

-

-

486820

condensation

Propionibacterium freudenreichii subsp. shermanii

-

-

486820

condensation

Rhodospirillum rubrum

-

-

486820

condensation

Novispirillum itersonii

-

-

486820

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PATHWAY SOURCE

PATHWAYS

BRENDA

heme metabolism

KEGG

Biosynthesis of secondary metabolites, Glycine, serine and threonine metabolism, Porphyrin and chlorophyll metabolism

MetaCyc

2-amino-3-hydroxycyclopent-2-enone biosynthesis, tetrapyrrole biosynthesis II (from glycine)

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SYSTEMATIC NAME

IUBMB Comments

succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

A pyridoxal-phosphate protein. The enzyme in erythrocytes is genetically distinct from that in other tissues.

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CAS REGISTRY NUMBER

COMMENTARY

9037-14-3

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

2-hydroxybutanoyl-CoA + glycine

? + CoA + CO2

Mus musculus

-

706627

Substrates: -
Products: -

?

5-aminolevulinate-CoA

2-amino-3-hydroxycyclopent-2-en-1-one + CoASH

Cereibacter sphaeroides

-

758299

Substrates: weak cyclization activity
Products: -

-

acetyl-CoA + glycine

?

11 entries

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

10 entries

butanoyl-CoA + glycine

? + CoA + CO2

Mus musculus

-

706627

Substrates: -
Products: -

?

butyryl-CoA + glycine

?

Cereibacter sphaeroides

-

486819

Substrates: low activity
Products: -

?

glutaryl-CoA + glycine

? + CoA + CO2

Mus musculus

-

706627

Substrates: -
Products: -

?

octanoyl-CoA + glycine

? + CoA + CO2

Mus musculus

-

706627

Substrates: -
Products: -

?

propionyl-CoA + glycine

?

Cereibacter sphaeroides

-

486819

Substrates: low activity
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

108 entries

succinyl-CoA + L-serine

?

Mus musculus

P08680

736454

Substrates: the reaction with L-serine follows a biphasic kinetic process
Products: -

?

succinyl-CoA + O-methylglycine

?

Mus musculus

P08680

736454

Substrates: -
Products: -

?

succinyl-CoA-monomethyl ester + glycine

5-aminolevulinic acid methyl ester + CoA + CO2

10 entries

additional information

?

-

7 entries

acetyl-CoA + glycine

?

Cavia porcellus

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Cereibacter sphaeroides

-

486819

Substrates: low activity
Products: -

?

acetyl-CoA + glycine

?

Cereibacter sphaeroides

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Gallus gallus

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Homo sapiens

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Oryctolagus cuniculus

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Propionibacterium freudenreichii subsp. shermanii

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Rattus norvegicus

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Rhodospirillum rubrum

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Saccharomyces cerevisiae

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

acetyl-CoA + glycine

?

Spinacia oleracea

-

486820

Substrates: at 2% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Cavia porcellus

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Cereibacter sphaeroides

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Gallus gallus

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Homo sapiens

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Oryctolagus cuniculus

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Propionibacterium freudenreichii subsp. shermanii

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Rattus norvegicus

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Rhodospirillum rubrum

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Saccharomyces cerevisiae

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

alpha-glutamyl-CoA + glycine

6-amino-5-oxohexanoate + CoA + CO2

Spinacia oleracea

-

486820

Substrates: at 9% the rate of the reaction with succinyl-CoA
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Acidipropionibacterium acidipropionici

-

720074

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Caulobacter vibrioides

Q9A8J8

758425

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Caulobacter vibrioides CB15

Q9A8J8

758425

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cavia porcellus

-

486843

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cavia porcellus

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cavia porcellus

-

486820

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cavia porcellus

-

486820

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486825, 486826, 486828, 486829, 486830, 486831, 486839, 486842, 486844, 486845, 757686

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

Q04512

757686

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

758299

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486811, 486819

Substrates: absolute requirement for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486811

Substrates: absolute requirement for succinyl-CoA
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486819

Substrates: enzyme utilizes acetyl-CoA, propionyl-CoA and butyryl-CoA at much lower rates
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486821

Substrates: glycine is formed by the reverse reaction under optimum conditions at 4-5% the rate of 5-aminolevulinate formed by the forward reaction under optimum conditions
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486850

Substrates: absolutely specific for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486820

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486850

Substrates: regulatory mechanisms in hepatic and erythroid cells
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides

-

486820

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides ATCC17023

Q04512

757686

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides ATCC17025

-

757686

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides ATCC17029

-

757686

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Cereibacter sphaeroides Y

-

486831, 486844, 486845

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Escherichia coli

-

677263, 719861

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Euglena gracilis

-

486850

Substrates: absolutely specific for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Gallus gallus

-

486814, 486818, 486832, 486836, 486853

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Gallus gallus

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Gallus gallus

-

486850

Substrates: absolutely specific for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Gallus gallus

-

486820, 486853

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Gallus gallus

-

486850

Substrates: regulatory mechanisms in hepatic and erythroid cells
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Gallus gallus

-

486818, 486820

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

486808, 486853, 719419, 758234

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

P22557

735684, 756091

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

756091

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

P22557

757677

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

P22557

736819

Substrates: -
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

486850

Substrates: absolutely specific for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

486820, 486853

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

486850

Substrates: regulatory mechanisms in hepatic and erythroid cells
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

486808, 486820

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

671812

Substrates: ALAS2 synthesizes heme specifically for haemoglobin
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Homo sapiens

-

671583

Substrates: first and rate-limiting step of heme biosynthesis. Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

486824, 486846, 486847, 486849, 486850, 486851, 486852, 486853, 486855, 486856, 486857, 486859, 486861, 663337, 704690, 706627, 718696

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

P08680

735711, 737145

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

737145

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

P08680

755944, 756992

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

756992

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

P08680

757255, 757676

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

757676

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

P08680

736116, 736454

Substrates: -
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

736454

Substrates: -
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

P08680

736491, 756100

Substrates: -
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

756100

Substrates: -
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

486853

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

486847

Substrates: cellular iron status plays a regulatory role
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

486850

Substrates: regulatory mechanisms in hepatic and erythroid cells
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

486824, 486859, 486861

Substrates: first step in heme biosynthesis pathway
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

486846, 486847, 486852, 486859, 486861

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

-

687586

Substrates: 5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathan’s hypothesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Mus musculus

P08680

736116

Substrates: it is the CoA, rather than the succinyl moiety, that facilitates binding of succinyl-CoA to wild-type ALAS
Products: -

r

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Novispirillum itersonii

-

486820

Substrates: -
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Novispirillum itersonii

-

486820

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Oncorhynchus mykiss

-

486816

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Oryctolagus cuniculus

-

486827

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Oryctolagus cuniculus

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Oryctolagus cuniculus

-

486820

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Oryctolagus cuniculus

-

486820

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Paracoccus denitrificans

-

486810

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Paracoccus denitrificans

-

486850

Substrates: absolutely specific for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Penaeus vannamei

-

756863

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Plasmodium falciparum

-

486860

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Propionibacterium freudenreichii subsp. shermanii

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Propionibacterium freudenreichii subsp. shermanii

-

486820

Substrates: key enzyme in tetrapyrrole biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Propionibacterium freudenreichii subsp. shermanii

-

486820

Substrates: rate-limiting enzyme of heme biosynthesis
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Rattus norvegicus

-

486813, 486818, 486822, 486823, 486833, 486834, 486837, 486838, 486841, 486843, 486848, 486851, 486853, 486858, 757560

Substrates: -
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Rattus norvegicus

-

486812

Substrates: absolute requirement for glycine
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Rattus norvegicus

-

486820

Substrates: absolute requirement for glycine
Products: -

ir

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Rattus norvegicus

-

486812

Substrates: absolute requirement for succinyl-CoA
Products: -

?

succinyl-CoA + glycine

5-aminolevulinate + CoA + CO2

Rattus norvegicus

-

486850

Substrates: absolutely specific for glycine
Products: -

?

succinyl-CoA + glycine