Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-allyl-2-isopropylacetamide | strong induction of enzyme in liver | Gallus gallus | |
2-allyl-2-isopropylacetamide | strong induction of enzyme in liver | Cavia porcellus | |
2-allyl-2-isopropylacetamide | strong induction of enzyme in liver | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyethyldisulfide | - |
Cereibacter sphaeroides | |
2-mercaptoethanol | - |
Oryctolagus cuniculus | |
2-oxoglutarate | - |
Cavia porcellus | |
2-oxoglutarate | - |
Cereibacter sphaeroides | |
2-oxoglutarate | - |
Gallus gallus | |
2-oxoglutarate | - |
Homo sapiens | |
2-oxoglutarate | - |
Oryctolagus cuniculus | |
2-oxoglutarate | - |
Propionibacterium freudenreichii subsp. shermanii | |
2-oxoglutarate | - |
Rattus norvegicus | |
2-oxoglutarate | - |
Rhodospirillum rubrum | |
2-oxoglutarate | - |
Saccharomyces cerevisiae | |
2-oxoglutarate | - |
Spinacia oleracea | |
aminomalonate | - |
Cereibacter sphaeroides | |
aminomalonate | - |
Gallus gallus | |
Aminomethylphosphonate | - |
Cavia porcellus | |
Aminomethylphosphonate | - |
Cereibacter sphaeroides | |
Aminomethylphosphonate | - |
Gallus gallus | |
Aminomethylphosphonate | - |
Homo sapiens | |
Aminomethylphosphonate | - |
Oryctolagus cuniculus | |
Aminomethylphosphonate | - |
Propionibacterium freudenreichii subsp. shermanii | |
Aminomethylphosphonate | - |
Rattus norvegicus | |
Aminomethylphosphonate | - |
Rhodospirillum rubrum | |
Aminomethylphosphonate | - |
Saccharomyces cerevisiae | |
Aminomethylphosphonate | - |
Spinacia oleracea | |
beta-Alanine | - |
Cereibacter sphaeroides | |
beta-Alanine | - |
Gallus gallus | |
Borohydride | in presence of pyridoxal 5'-phosphate | Cereibacter sphaeroides | |
Cu2+ | - |
Cereibacter sphaeroides | |
Cu2+ | - |
Rhodospirillum rubrum | |
cyanide | - |
Gallus gallus | |
Diethyl aminomalonate | - |
Cereibacter sphaeroides | |
Diethyl aminomalonate | - |
Gallus gallus | |
ethanolamine | - |
Cereibacter sphaeroides | |
ethanolamine | - |
Gallus gallus | |
ethanolamine | - |
Rhodospirillum rubrum | |
Fe2+ | - |
Cereibacter sphaeroides | |
Fe3+ | no inhibition | Cereibacter sphaeroides | |
Fe3+ | - |
Oryctolagus cuniculus | |
ferroheme | - |
Cavia porcellus | |
ferroheme | - |
Cereibacter sphaeroides | |
ferroheme | - |
Gallus gallus | |
ferroheme | - |
Homo sapiens | |
ferroheme | - |
Oryctolagus cuniculus | |
ferroheme | - |
Propionibacterium freudenreichii subsp. shermanii | |
ferroheme | - |
Rattus norvegicus | |
ferroheme | - |
Rhodospirillum rubrum | |
ferroheme | - |
Saccharomyces cerevisiae | |
ferroheme | - |
Spinacia oleracea | |
glutathione | - |
Oryctolagus cuniculus | |
hemin | - |
Cavia porcellus | |
hemin | - |
Cereibacter sphaeroides | |
hemin | - |
Gallus gallus | |
hemin | - |
Homo sapiens | |
hemin | - |
Oryctolagus cuniculus | |
hemin | - |
Propionibacterium freudenreichii subsp. shermanii | |
hemin | - |
Rattus norvegicus | |
hemin | - |
Rhodospirillum rubrum | |
hemin | - |
Saccharomyces cerevisiae | |
hemin | - |
Spinacia oleracea | |
hemoglobin | - |
Cavia porcellus | |
hemoglobin | - |
Cereibacter sphaeroides | |
hemoglobin | - |
Gallus gallus | |
hemoglobin | - |
Homo sapiens | |
hemoglobin | - |
Oryctolagus cuniculus | |
hemoglobin | - |
Propionibacterium freudenreichii subsp. shermanii | |
hemoglobin | - |
Rattus norvegicus | |
hemoglobin | - |
Rhodospirillum rubrum | |
hemoglobin | - |
Saccharomyces cerevisiae | |
hemoglobin | - |
Spinacia oleracea | |
iodoacetamide | - |
Cereibacter sphaeroides | |
Isobutylamine | - |
Cereibacter sphaeroides | |
Isobutylamine | - |
Gallus gallus | |
L-alanine | - |
Cereibacter sphaeroides | |
L-alanine | - |
Gallus gallus | |
L-cysteine | - |
Gallus gallus | |
L-Penicillamine | - |
Gallus gallus | |
L-threonine | - |
Cereibacter sphaeroides | |
L-threonine | - |
Gallus gallus | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Cavia porcellus | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Cereibacter sphaeroides | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Gallus gallus | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Homo sapiens | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Oryctolagus cuniculus | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Propionibacterium freudenreichii subsp. shermanii | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Rattus norvegicus | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Rhodospirillum rubrum | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Saccharomyces cerevisiae | |
metalloporphyrins | containing Co2+, Zn2+ or Mg2+ | Spinacia oleracea | |
myoglobin | - |
Cavia porcellus | |
myoglobin | - |
Cereibacter sphaeroides | |
myoglobin | - |
Gallus gallus | |
myoglobin | - |
Homo sapiens | |
myoglobin | - |
Oryctolagus cuniculus | |
myoglobin | - |
Propionibacterium freudenreichii subsp. shermanii | |
myoglobin | - |
Rattus norvegicus | |
myoglobin | - |
Rhodospirillum rubrum | |
myoglobin | - |
Saccharomyces cerevisiae | |
myoglobin | - |
Spinacia oleracea | |
p-mercuribenzoate | - |
Cereibacter sphaeroides | |
p-mercuribenzoate | - |
Gallus gallus | |
pyruvate | - |
Cavia porcellus | |
pyruvate | - |
Cereibacter sphaeroides | |
pyruvate | - |
Gallus gallus | |
pyruvate | - |
Homo sapiens | |
pyruvate | - |
Oryctolagus cuniculus | |
pyruvate | - |
Propionibacterium freudenreichii subsp. shermanii | |
pyruvate | - |
Rattus norvegicus | |
pyruvate | - |
Rhodospirillum rubrum | |
pyruvate | - |
Saccharomyces cerevisiae | |
pyruvate | - |
Spinacia oleracea |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Cavia porcellus | |
additional information | - |
additional information | - |
Homo sapiens | |
additional information | - |
additional information | - |
Saccharomyces cerevisiae | |
additional information | - |
additional information | - |
Spinacia oleracea | |
additional information | - |
additional information | - |
Propionibacterium freudenreichii subsp. shermanii | |
additional information | - |
additional information | overview | Gallus gallus | |
additional information | - |
additional information | overview | Rattus norvegicus | |
additional information | - |
additional information | overview | Oryctolagus cuniculus | |
additional information | - |
additional information | overview | Cereibacter sphaeroides |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Cavia porcellus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Cavia porcellus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Oryctolagus cuniculus | 5739 | - |
additional information | synthesized in microsomes and then migrates to the mitochondria | Cavia porcellus | - |
- |
additional information | synthesized in microsomes and then migrates to the mitochondria | Homo sapiens | - |
- |
additional information | synthesized in microsomes and then migrates to the mitochondria | Rattus norvegicus | - |
- |
additional information | synthesized in microsomes and then migrates to the mitochondria | Oryctolagus cuniculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Gallus gallus |
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Rattus norvegicus |
additional information | - |
- |
Cereibacter sphaeroides |
200000 | - |
gel filtration | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | Gallus gallus | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Cavia porcellus | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Homo sapiens | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Rattus norvegicus | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Saccharomyces cerevisiae | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Oryctolagus cuniculus | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Cereibacter sphaeroides | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Spinacia oleracea | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Propionibacterium freudenreichii subsp. shermanii | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Rhodospirillum rubrum | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Novispirillum itersonii | key enzyme in tetrapyrrole biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Gallus gallus | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Cavia porcellus | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Homo sapiens | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Rattus norvegicus | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Saccharomyces cerevisiae | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Oryctolagus cuniculus | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Cereibacter sphaeroides | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Spinacia oleracea | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Propionibacterium freudenreichii subsp. shermanii | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | Rhodospirillum rubrum | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Cereibacter sphaeroides | - |
enzyme exists in an inactive or low activity form which can under certain conditions become activated, spontaneous activation in presence of oxygen or an oxidizing agent shows a pH dependence with an optimum at about pH 7.0, assisted by 2-mercaptoethanol | - |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
no activity in Chromatium sp. | - |
- |
- |
Novispirillum itersonii | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Propionibacterium freudenreichii subsp. shermanii | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rhodospirillum rubrum | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Spinacia oleracea | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Oryctolagus cuniculus |
- |
Cereibacter sphaeroides |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Gallus gallus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Cavia porcellus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Homo sapiens | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Rattus norvegicus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Saccharomyces cerevisiae | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Oryctolagus cuniculus | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Cereibacter sphaeroides | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Spinacia oleracea | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Propionibacterium freudenreichii subsp. shermanii | |
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism | Rhodospirillum rubrum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Gallus gallus | - |
erythrocyte | - |
Homo sapiens | - |
harderian gland | - |
Rattus norvegicus | - |
liver | - |
Gallus gallus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
reticulocyte | - |
Rattus norvegicus | - |
reticulocyte | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
various tissues, overview | Gallus gallus |
additional information | - |
various tissues, overview | Homo sapiens |
additional information | - |
various tissues, overview | Rattus norvegicus |
additional information | - |
various tissues, overview | Oryctolagus cuniculus |
additional information | - |
various tissues, overview | Cereibacter sphaeroides |
additional information | - |
various tissues, overview | Propionibacterium freudenreichii subsp. shermanii |
additional information | - |
various tissues, overview | Rhodospirillum rubrum |
additional information | - |
various tissues, overview | Novispirillum itersonii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Gallus gallus | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Cavia porcellus | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Homo sapiens | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Rattus norvegicus | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Saccharomyces cerevisiae | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Oryctolagus cuniculus | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Cereibacter sphaeroides | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Spinacia oleracea | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Propionibacterium freudenreichii subsp. shermanii | ? | - |
? | |
acetyl-CoA + glycine | at 2% the rate of the reaction with succinyl-CoA | Rhodospirillum rubrum | ? | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Gallus gallus | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Cavia porcellus | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Homo sapiens | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Rattus norvegicus | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Saccharomyces cerevisiae | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Oryctolagus cuniculus | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Cereibacter sphaeroides | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Spinacia oleracea | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Propionibacterium freudenreichii subsp. shermanii | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
alpha-glutamyl-CoA + glycine | at 9% the rate of the reaction with succinyl-CoA | Rhodospirillum rubrum | 6-amino-5-oxohexanoate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | - |
Novispirillum itersonii | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Gallus gallus | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Cavia porcellus | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Saccharomyces cerevisiae | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Oryctolagus cuniculus | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Cereibacter sphaeroides | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Spinacia oleracea | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Propionibacterium freudenreichii subsp. shermanii | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | absolute requirement for glycine | Rhodospirillum rubrum | 5-aminolevulinate + CoA + CO2 | - |
ir | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Gallus gallus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Cavia porcellus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Saccharomyces cerevisiae | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Oryctolagus cuniculus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Cereibacter sphaeroides | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Spinacia oleracea | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Propionibacterium freudenreichii subsp. shermanii | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Rhodospirillum rubrum | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | key enzyme in tetrapyrrole biosynthesis | Novispirillum itersonii | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Gallus gallus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Cavia porcellus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Saccharomyces cerevisiae | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Oryctolagus cuniculus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Cereibacter sphaeroides | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Spinacia oleracea | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Propionibacterium freudenreichii subsp. shermanii | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Rhodospirillum rubrum | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Gallus gallus | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Cavia porcellus | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Homo sapiens | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Rattus norvegicus | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Saccharomyces cerevisiae | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Oryctolagus cuniculus | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Cereibacter sphaeroides | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Spinacia oleracea | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Propionibacterium freudenreichii subsp. shermanii | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? | |
succinyl-CoA-monomethyl ester + glycine | at 80% the rate of the reaction with succinyl-CoA | Rhodospirillum rubrum | 5-aminolevulinic acid methyl ester + CoA + CO2 | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
additional information | - |
temperature insensitive | Cereibacter sphaeroides |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Gallus gallus | |
pyridoxal 5'-phosphate | - |
Cavia porcellus | |
pyridoxal 5'-phosphate | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
pyridoxal 5'-phosphate | - |
Saccharomyces cerevisiae | |
pyridoxal 5'-phosphate | - |
Oryctolagus cuniculus | |
pyridoxal 5'-phosphate | - |
Spinacia oleracea | |
pyridoxal 5'-phosphate | - |
Propionibacterium freudenreichii subsp. shermanii | |
pyridoxal 5'-phosphate | - |
Rhodospirillum rubrum | |
pyridoxal 5'-phosphate | - |
Novispirillum itersonii | |
pyridoxal 5'-phosphate | bound to the enzyme through a Schiff base linkage | Cereibacter sphaeroides |