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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine - Arabidopsis thaliana AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine - ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [ubiquitin-activating protein UBA1]-L-cysteine enzyme forms higher molecular mass intermediates with ubiquitin Arabidopsis thaliana AMP + diphosphate + [ubiquitin-activating protein UBA1]-S-ubiquitinyl-L-cysteine the enzyme-ubiquitin intermediates dissociate in presence of 2-mercaptoethanol, indicating thiolester linkage ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [ubiquitin-activating protein UBA2]-L-cysteine enzyme forms higher molecular mass intermediates with ubiquitin Arabidopsis thaliana AMP + diphosphate + [ubiquitin-activating protein UBA2]-S-ubiquitinyl-L-cysteine the enzyme-ubiquitin intermediates dissociate in presence of 2-mercaptoethanol, indicating thiolester linkage ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [ubiquitin-activating protein E1]-L-cysteine - Bos taurus AMP + diphosphate + [ubiquitin-activating protein E1]-S-ubiquitinyl-L-cysteine - ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin mutant G76A + [ubiquitin-activating protein E1]-L-cysteine - Bos taurus AMP + diphosphate + [ubiquitin-activating protein E1]-S-(ubiquitin mutant G76A)yl-L-cysteine mutant ubiquitin G76A, bearing a Gly to Ala substitution at the COOH terminus is a substrate for El enzyme. Ubiquitin G76A supports PPI-ATP exchange with 500fold decrease in kcat/Km compared to wild-type ubiquitin, does not produce detectable AMP-Ub with native El, produces stoichiometric AMP-Ub with thiol-blocked El, gives a stoichiometric burst of ATP consumption with either native or thiol-blocked El, support El-ubiquitin thiol ester formation with native El, and supports several downstream reactions of the proteolytic pathway with a 20% decrease to the rate of wild type ubiquitin ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine - Citrus reticulata AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine - ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine - Drosophila melanogaster AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine - ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [ubiquitin-activating protein E1]-L-cysteine a carboxylgroup is first activated as an adenylate followed by its direct transfer to an autonomous molecular moiety in a single enzymatic step Escherichia coli AMP + diphosphate + [ubiquitin-activating protein E1]-S-ubiquitinyl-L-cysteine - ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45more a lysine 48-linked polyubiquitin chain, assembled upon an internal lysine residue of a substrate protein, becomes the principle signal for recognition and target degradation by the 26S proteasome. E1 is not only essential for the initial ATP-dependent activation of ubiquitin in the ubiquitin degradtion pathway, but also capable of the catalytic extension of the polyubiquitin chain on a mono-ubiquitinated substrate Escherichia coli ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.45ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine - Giardia intestinalis AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine - ?
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