EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
- |
Escherichia coli |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
committed step of folate synthesis in bacteria |
Escherichia coli |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
the second step in the pterin branch of the folate synthesis pathway |
Lactococcus lactis |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
no activity against deoxynucleoside triphosphates |
Lactococcus lactis |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
the enzyme is far more active against dGTP, 8-oxo-GTP, dTTP, and other nucleoside and deoxynucleoside 3'-triphosphates than against 7,8-dihydroneopterin 3'-triphosphate |
Arabidopsis thaliana |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
key enzyme in the folate pathway |
Escherichia coli |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
the enzyme participates in a folate biosynthesis pathway |
Escherichia coli |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
catalytic efficiency of the enzyme is far higher for dGTP |
Arabidopsis thaliana |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
no detectable activity with GTP, ATP, TTP, CTP, the corresponding deoxynucleoside triphosphates, 8-oxo-dGTP, NADH, NAD, diadenosine tri- or tetraphosphate, ADP-ribose, UDP-glucose, or coenzyme A (the detection limit is less than 1% of the activity with 7,8-dihydroneopterin 3'-triphosphate) |
Lactococcus lactis |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |
3.6.1.67 | 7,8-dihydroneopterin 3'-triphosphate + H2O |
the second step in the pterin branch of the folate synthesis pathway |
Lactococcus lactis NZ9000 |
7,8-dihydroneopterin 3'-phosphate + diphosphate |
- |
? |