EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.1.134 | ATP + 1D-myo-inositol 1,4,6-trisphosphate |
- |
Arabidopsis thaliana |
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate |
- |
? |
2.7.1.134 | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate |
- |
Arabidopsis thaliana |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate |
- |
? |
2.7.1.134 | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate |
enzyme ITPK1 has robust enantiospecific hydroxykinase activity against Ins(3,4,5,6)P4 |
Arabidopsis thaliana |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate |
- |
? |
2.7.1.134 | ATP + 1D-myo-inositol 3,4,6-trisphosphate |
- |
Arabidopsis thaliana |
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate |
- |
? |
2.7.1.134 | more |
the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate |
Arabidopsis thaliana |
? |
- |
? |
2.7.1.134 | more |
substrate docking calculations, substrate specificity of Arabidopsis thaliana ITPK1, overview. Lack of Ins(1,4,5,6)P4/Ins(3,4,5,6) P4 product for Ins(1,4,6)P3 or Ins(3,4,6)P3 substrates. Consistent with the phosphorylation of the enantiomeric pair Ins(1,4,5,6)P4/Ins (3,4,5,6)P4, ITPK1 shows phosphorylation of Ins(1,4,6)P3 at the 3-position and Ins(3,4,6)P3 at the 1-position. ITPK1 has robust enantiospecific hydroxykinase activity against Ins(3,4,5,6)P4. With inositol tris/tetrakisphosphate kinase 1 (ITPK1, EC 2.7.1.134) and inositol pentakisphosphate 2-kinase (IPK1, EC 2.7.1.158) combined at a 1:20 ATP:ADP ratio, InsP6 is converted via Ins(1,3,4,5,6)P5 to Ins(3,4,5,6) P4 and/or Ins(1,4,5,6)P4 with concomitant generation of ATP |
Arabidopsis thaliana |
? |
- |
- |
2.7.1.134 | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate |
- |
Arabidopsis thaliana Col-0 |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate |
- |
? |
2.7.1.134 | more |
the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate |
Arabidopsis thaliana Col-0 |
? |
- |
? |
2.7.1.134 | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate |
- |
Bos taurus |
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate |
- |
? |
2.7.1.134 | ATP + myo-inositol-1,3,4-trisphosphate |
- |
Bos taurus |
ADP + myo-inositol-1,3,4,6-tetrakisphosphate |
- |
? |