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Information on EC 2.7.1.134 - inositol-tetrakisphosphate 1-kinase

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IUBMB Comments
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.
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The enzyme appears in viruses and cellular organisms
Synonyms
inositol 1,3,4-trisphosphate 5/6-kinase, osipk, hvipk, itpk2, inositol 1,3,4-trisphosphate 5/6 kinase, inositol 1,4,5,6-tetrakisphosphate 3-kinase, ipk kinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
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