Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 2.7.1.134 - inositol-tetrakisphosphate 1-kinase

for references in articles please use BRENDA:EC2.7.1.134

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. The enzymes from animals and plants also have the activity of EC 2.7.1.159, inositol-1,3,4-trisphosphate 5/6-kinase.

The expected taxonomic range for this enzyme is: Eukaryota, Archaea

Synonyms
inositol 1,3,4-trisphosphate 5/6-kinase, osipk, itpk2, ositpk6, hvipk, inositol 1,3,4-trisphosphate 5/6 kinase, inositol tris/tetrakisphosphate kinase 1, inositol-tetrakisphosphate 1-kinase, inositol 1,4,5,6-tetrakisphosphate 3-kinase, ipk kinase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza), D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links