EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.114 | more |
wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol |
Homo sapiens |
? |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-((2E,6E)-farnesyl)benzoate |
- |
Rattus norvegicus |
S-adenosyl-L-homocysteine + 5-((2E,6E)-farnesyl)-4-hydroxy-3-methoxybenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate |
- |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-farnesylbenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate |
in vitro assay |
Homo sapiens |
S-adenosyl-L-homocysteine + 5-(2E,6E)-farnesyl-4-hydroxy-3-methoxybenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate |
- |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate |
3,4-dihydroxy-5-all-trans-hexaprenylbenzoate is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (that is methylated by the yeast enzyme CoQ3 to 4-hydroxy-3-methoxy-5-hexaprenylbenzoate). When expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast |
Homo sapiens |
S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate |
- |
Caenorhabditis elegans |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate |
- |
Escherichia coli |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate |
- |
? |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate |
- |
Caenorhabditis elegans N2 |
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate |
- |
? |