EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.2.1.2 | ATP + 2-anthracenecarboxylic acid + CoA |
16% of the activity with hexanoic acid |
Bos taurus |
AMP + diphosphate + anthracene-2-carboxyl-CoA |
- |
? |
6.2.1.2 | ATP + 2-methylbutyrate + CoA |
when propionate or other less favorable acyl substrates, such as butyrate, 2-methylpropionate, or 2-methylvalerate, are utilized, the acyl-CoA is not produced or is produced at reduced levels. Instead, acyl-AMP and diphosphate are released in the absence of CoA, whereas in the presence of CoA, the intermediate is broken down into AMP and the acyl substrate, which are released along with diphosphate. These results suggest that although acyl-CoA synthetases may have the ability to utilize a broad range of substrates for the acyl-adenylate-forming first step of the reaction, the intermediate may not be suitable for the thioester-forming second step |
Methanosarcina acetivorans |
AMP + diphosphate + 2-methylbutyryl-CoA |
- |
? |
6.2.1.2 | ATP + 2-methylbutyrate + CoA |
when propionate or other less favorable acyl substrates, such as butyrate, 2-methylpropionate, or 2-methylvalerate, are utilized, the acyl-CoA is not produced or is produced at reduced levels. Instead, acyl-AMP and diphosphate are released in the absence of CoA, whereas in the presence of CoA, the intermediate is broken down into AMP and the acyl substrate, which are released along with diphosphate. These results suggest that although acyl-CoA synthetases may have the ability to utilize a broad range of substrates for the acyl-adenylate-forming first step of the reaction, the intermediate may not be suitable for the thioester-forming second step |
Methanosarcina acetivorans DSM 2834 |
AMP + diphosphate + 2-methylbutyryl-CoA |
- |
? |
6.2.1.2 | ATP + 2-naphthylacetic acid + CoA |
21% of the activity with hexanoic acid |
Bos taurus |
AMP + diphosphate + 2-naphthyl-acetyl-CoA |
- |
? |
6.2.1.2 | ATP + 2-naphthylacetic acid + CoA |
about 35% of the activity with hexanoic acid |
Mus musculus |
AMP + diphosphate + 2-naphthyl-acetyl-CoA |
- |
? |
6.2.1.2 | ATP + 3,4-methylenedioxycinnamic acid + CoA |
high activity |
Penicillium chrysogenum |
AMP + diphosphate + 3,4-methylenedioxy-cinnamoyl-CoA |
- |
? |
6.2.1.2 | ATP + 3-aminobenzoate + CoA |
29% of the activity with benzoate |
Mus musculus |
AMP + diphosphate + 3-aminobenzoyl-CoA |
- |
? |
6.2.1.2 | ATP + 3-aminobenzoate + CoA |
5% of the activity with hexanoic acid |
Bos taurus |
AMP + diphosphate + 3-aminobenzoyl-CoA |
- |
? |
6.2.1.2 | ATP + 3-chlorobenzoate + CoA |
12% of the activity with hexanoic acid |
Bos taurus |
AMP + diphosphate + 3-chlorobenzoyl-CoA |
- |
? |
6.2.1.2 | ATP + 3-chlorobenzoate + CoA |
126% of the activity with benzoate |
Mus musculus |
AMP + diphosphate + 3-chlorobenzoyl-CoA |
- |
? |