EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.17.23 | more |
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited |
Homo sapiens |
? |
- |
? |
3.4.17.23 | more |
ACE2 functions predominantly as a carboxymonopeptidase with a substrate preference for hydrolysis between proline and a hydrophobic or basic C-terminal residue |
Homo sapiens |
? |
- |
? |
3.4.17.23 | more |
hydrolyses its substrates by removing a single amino acid from their respective C-terminal |
Homo sapiens |
? |
- |
? |
3.4.17.23 | more |
ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue |
Mus musculus |
? |
- |
? |
3.4.17.23 | more |
ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue |
Rattus norvegicus |
? |
- |
? |
3.4.17.23 | more |
ACE2 is a terminal carboxypeptidase and the receptor for the SARS and NL63 coronaviruses. Soluble sACE2 acts as receptor binding SARS-CoV glycoprotein S pseudotyped FIV virus and blocks virus infection of target cells |
Homo sapiens |
? |
- |
? |
3.4.17.23 | more |
a combination of ACE2 and ACE convert amyloid-beta protein 43 to amyloid-beta protein 40 |
Mus musculus |
? |
- |
? |
3.4.17.23 | more |
the requirements for ACE2 binding at the first position of a tetrapeptide substrate, i.e. fourth position from the Ang II C-terminus XHPF, are a preference for non-polar, hydrophobic or cyclic residues, with Val and Pro substitutions showing enhanced binding. No strict preference is observed at position two of the tetrapeptide IXPF. Apolar cyclic residues Phe and Pro are not tolerated at the position. Substitution of position three results in moderate increases in binding for Val, 77% and decreases for Ile. The only other functional group tolerated at this position is naphthalene. Peptides PYPF/PHVF/PYVF show almost equivalent ACE2 binding compared to full-length angiotensin II |
Homo sapiens |
? |
- |
? |
3.4.17.23 | neocasomorphin + H2O |
- |
Homo sapiens |
neocasomorphin minus C-terminal amino acid + isoleucine |
- |
ir |
3.4.17.23 | neurotensin + H2O |
- |
Mus musculus |
? |
- |
? |