EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    2.7.4.14 | ATP + CMP |
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis |
Homo sapiens |
ADP + CDP |
- |
? |
| 2.7.4.14 | ATP + dCMP |
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis |
Homo sapiens |
ADP + dCDP |
- |
? |
| 2.7.4.14 | ATP + UMP |
the enzyme plays a crucial role in the formation of UDP, CDP and dCDP which are required for cellular nucleic acid synthesis |
Homo sapiens |
ADP + UDP |
- |
? |
| 2.7.4.14 | more |
the enzyme shows enantioselectivity, acceptor-binding site structure of human UMP-CMP kinase in the closed form or in ligand-bound forms, overview |
Homo sapiens |
? |
- |
? |
| 2.7.4.14 | more |
the UMP-CMP kinase has a relaxed enantiospecificity for the nucleoside monophosphate acceptor site, but it is restricted to D-nucleotides at the donor site |
Homo sapiens |
? |
- |
? |
| 2.7.4.14 | more |
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response |
Homo sapiens |
? |
- |
? |
| 2.7.4.14 | ATP + 5-aza-cidofovir |
wild-type enzyme |
Homo sapiens |
ADP + phospho-5-aza-cidofovir |
- |
? |
| 2.7.4.14 | ATP + dUMP |
wild-type enzyme |
Homo sapiens |
ADP + dUDP |
- |
? |
| 2.7.4.14 | ATP + CMP |
wild-type enzyme and mutant P64T |
Homo sapiens |
ADP + CDP |
- |
? |
| 2.7.4.14 | ATP + dCMP |
wild-type enzyme and mutant P64T |
Homo sapiens |
ADP + dCDP |
- |
? |
