EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.10 | ATP + [IkappaBbeta protein] |
- |
Homo sapiens |
ADP + [IkappaBbeta phosphoprotein] |
- |
? |
2.7.11.10 | ATP + [NFkappaB subunit p56] |
- |
Homo sapiens |
ADP + [NFkappaB subunit p56]phosphate |
- |
? |
2.7.11.10 | ATP + [RelA/p65 protein] |
- |
Mus musculus |
ADP + [RelA/p65 phosphoprotein] |
- |
? |
2.7.11.10 | ATP + IkappaBalpha |
a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer |
Homo sapiens |
ADP + phosphorylated IkappaBalpha |
- |
? |
2.7.11.10 | more |
activated IKK2 is responsible for induction of leucocyte infiltration in pancreatic acini, the mutant ICC2CA in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitits, the enzyme is involved in the proinflammatory IKK/NF-kappaB pathway, overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
activation of heterodimeric nuclear transcription factor NFkappaB is an essential step in inflammation, e.g. resulting in osteoarthritis, ulcerative colitis, asthma, and Crohn's disease, signalling step for phosphorylation, subsequent ubiquitination and proteolytic degradation of IkappaB, NFkappaB remains free after the reaction and is translocated to the nucleus, NFkappaB activation is also involved in development of diseases like cancer, gut ischemia-reperfusion, diabetes, or in transplant rejections, overview |
Homo sapiens |
? |
- |
? |
2.7.11.10 | more |
activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection |
Mus musculus C57/BL6J |
? |
- |
? |
2.7.11.10 | ATP + GST-IkappaBalpha |
activity assay |
Homo sapiens |
ADP + GST-IkappaBalpha phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
autophosphorylation at both Ser and Thr |
Myxococcus xanthus |
ADP + a phosphoprotein |
- |
? |