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TaxTree of Organism Mus musculus C57/BL6J
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EC NUMBER 
COMMENTARY 
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preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
preliminary BRENDA-supplied EC number
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(S)-reticuline biosynthesis I
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PWY-3581
(S)-reticuline biosynthesis II
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PWY-6133
1,5-anhydrofructose degradation
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PWY-6992
15-epi-lipoxin biosynthesis
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PWY66-393
2-arachidonoylglycerol biosynthesis
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PWY-8052
2-methylpropene degradation
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PWY-7778
3-hydroxypropanoate cycle
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PWY-5743
3-hydroxypropanoate/4-hydroxybutanate cycle
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PWY-5789
3-phosphoinositide degradation
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PWY-6368
anandamide biosynthesis I
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PWY-8051
anandamide biosynthesis II
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PWY-8053
anandamide degradation
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PWY6666-1
anandamide lipoxygenation
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PWY-8056
arachidonate metabolites biosynthesis
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PWY-8397
aspirin triggered resolvin D biosynthesis
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PWY66-395
aspirin triggered resolvin E biosynthesis
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PWY66-394
betalamic acid biosynthesis
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PWY-5394
brassicicene C biosynthesis
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PWY-7517
butanol and isobutanol biosynthesis (engineered)
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PWY-7396
C20 prostanoid biosynthesis
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PWY66-374
C4 photosynthetic carbon assimilation cycle, NAD-ME type
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PWY-7115
C4 photosynthetic carbon assimilation cycle, NADP-ME type
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PWY-241
C4 photosynthetic carbon assimilation cycle, PEPCK type
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PWY-7117
catecholamine biosynthesis
CDP-diacylglycerol biosynthesis I
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PWY-5667
CDP-diacylglycerol biosynthesis II
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PWY0-1319
CDP-diacylglycerol biosynthesis III
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PWY-5981
chondroitin biosynthesis
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PWY-6566
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)
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PWY-6138
CMP-N-acetylneuraminate biosynthesis II (bacteria)
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PWY-6139
CO2 fixation into oxaloacetate (anaplerotic)
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PWYQT-4429
cyanate degradation
di-homo-gamma-linolenate metabolites biosynthesis
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PWY-8396
diacylglycerol and triacylglycerol biosynthesis
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TRIGLSYN-PWY
docosahexaenoate metabolites biosynthesis
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PWY-8400
fatty acid biosynthesis initiation (type I)
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PWY-5966-1
fructose 2,6-bisphosphate biosynthesis
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PWY66-423
fusicoccin A biosynthesis
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PWY-6659
geranylgeranyl diphosphate biosynthesis
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PWY-5120
gluconeogenesis II (Methanobacterium thermoautotrophicum)
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PWY-6142
glycine betaine degradation I
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PWY-3661
glycine betaine degradation II (mammalian)
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PWY-3661-1
glyoxylate assimilation
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PWY-5744
icosapentaenoate metabolites biosynthesis
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PWY-8399
isoprene biosynthesis II (engineered)
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PWY-7391
jadomycin biosynthesis
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PWY-6679
L-lysine degradation V
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PWY-5283
L-methionine salvage from L-homocysteine
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ADENOSYLHOMOCYSCAT-PWY
leukotriene biosynthesis
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PWY66-375
linoleate metabolites biosynthesis
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PWY-8395
lipoxin biosynthesis
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PWY66-392
maresin biosynthesis
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PWY-8356
methyl phomopsenoate biosynthesis
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PWY-7721
mevalonate pathway I (eukaryotes and bacteria)
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PWY-922
mevalonate pathway II (haloarchaea)
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PWY-6174
mevalonate pathway III (Thermoplasma)
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PWY-7524
mevalonate pathway IV (archaea)
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PWY-8125
mitochondrial L-carnitine shuttle
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PWY-6111
monoacylglycerol metabolism (yeast)
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PWY-7420
NAD salvage pathway IV (from nicotinamide riboside)
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PWY3O-4106
NAD(P)/NADPH interconversion
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PWY-5083
nicotine degradation IV
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PWY66-201
oleate biosynthesis II (animals and fungi)
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PWY-5996
oleate biosynthesis III (cyanobacteria)
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PWY-7587
ophiobolin F biosynthesis
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PWY-7720
palmitoleate biosynthesis III (cyanobacteria)
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PWY-7589
palmitoleate biosynthesis IV (fungi and animals)
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PWY3O-1801
palmitoyl ethanolamide biosynthesis
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PWY-8055
paspaline biosynthesis
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PWY-7492
peptido-conjugates in tissue regeneration biosynthesis
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PWY-8355
phosphatidate biosynthesis (yeast)
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PWY-7411
phospholipid remodeling (phosphatidate, yeast)
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PWY-7417
plasmalogen biosynthesis I (aerobic)
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PWY-7782
plaunotol biosynthesis
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PWY-6691
poly-hydroxy fatty acids biosynthesis
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PWY-6710
protein N-glycosylation initial phase (eukaryotic)
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MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS
purine deoxyribonucleosides salvage
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PWY-7224
pyrimidine deoxyribonucleosides salvage
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PWY-7199
resolvin D biosynthesis
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PWY66-397
retinol biosynthesis
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PWY-6857
rosmarinic acid biosynthesis II
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PWY-5049
serine racemization
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PWY-8140
sorgoleone biosynthesis
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PWY-5987
sphingolipid biosynthesis (mammals)
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PWY-7277
sphingomyelin metabolism
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PWY3DJ-11281
stellatic acid biosynthesis
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PWY-7736
stigma estolide biosynthesis
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PWY-6453
taurine biosynthesis I
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PWY-5331
taurine biosynthesis II
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PWY-7850
the visual cycle I (vertebrates)
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PWY-6861
triacylglycerol degradation
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LIPAS-PWY
vancomycin resistance II
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PWY-6455
catecholamine biosynthesis
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PWY66-301
cyanate degradation
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CYANCAT-PWY
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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487133, 678978, 714340, 714940, 715716, 716432, 716685, 718064, 719538, 721984, 722738, 723029, 725068, 725514, 725541, 726260, 730684, 731537, 732240, 732361, 735574, 742757
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SwissProt
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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distribution of enzyme expression within the tissue in situ, overview
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highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview
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a dopaminergic cell line, generated by fusion of rostral mesencephalic neurons from embryonic C57BL/6J mice with N18TG2 neuroblastoma cells
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developmental regulation of enzyme expression, in situ hybridization analysis, overview, D-serine levels are quite high in ganglion cells of neonatal retinas and decreasing rapidly postnatally
additional information
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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quantitative analysis of Csgalnact1 and Csgalnact2 transcripts in brain of wild-type and Csgalnact1-/- mice by real-time PCR, overview
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widely expressed in adult mouse brain. SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice, semiquantitative RT-PCR expression analysis
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no increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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the nuclear thimet oligopeptidase is coexpressed with estrogen receptor alpha in hypothalamic cells, and also in ventrolateral portion of the ventromedial hypothalamic nucleus and the midbrain central grey
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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expression of lipogenic genes and the activity of fatty acid synthase in the liver are repressed and lipid stores in adipose tissue are mobilized in GCN2 wild-type mice upon leucine deprivation
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high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview
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increased enzyme activity in obese mice compared to twild-type mice, overview
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treatment with Scd1 sequence-specific antisense oligodeoxynucleotide decreases mRNA and protein, real-time PCR
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increased ECE-1 protein content (immunohistochemistry, immunoblot) and mRNA expression (Northern blot) in apolipoprotein E-deficient mouse
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primary cerebellar granule neuron and NSC34 spinal cord motoneuron cell culture
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UCH-L1 is localized on the inside of the plasma membrane of dorsal root ganglion neurons
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cyclic AMP levels in photoreceptor cells are highest in darkness and reduced by light exposure
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AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina
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intact retina of 1-3 day, 3 week, and 18 week old mouse. Robust expression of serine racemase, levels are developmentally regulated, with high levels during the early postnatal period, but diminishing considerably in the mature retina. D-Serine levels are regulated accordingly.
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lipin-2, in whole spleen and the white blood cell fraction of spleen, at ca. 10% of the levels observed in liver
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high expression level, expression of the enzyme in the testis increases significantly in an age-dependent manner
additional information
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asparagine-linked glycosylation 2 (Alg2) is commonly downregulated in BMP-2-induced osteoblast differentiation in both MC3T3-E1 and ST-2 cells
additional information
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immunohistochemic analysis, ubiquitous expression in central nerous system cells, overview
additional information
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LPL is expressed in a wide variety of cell types, particularly in adipocytes and myocytes
additional information
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mGne1 is the ubiquitously expressed, major mouse isoform, isozyme mGne2 encoding transcript is differentially expressed, quantitative real-time PCR isozyme expression analysis
additional information
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mGne2 encoding transcript is differentially expressed mGne2. Expression is significantly increased the first 2 days of life, possibly reflecting the high sialic acid demand during this period, quantitative real-time PCR isozyme expression analysis
additional information
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present in BMM cells. Osteoclasts and macrophages lack AMPK beta2 subunit expression
additional information
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quantitative PCR-based enzyme expression analysis in spinal cord injury, overview
additional information
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real-time PCR quantitative mRNA analysis and activity distribution in control and stimulated brain sections, overview
additional information
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sEH tissue distribution, no activity in lung, overview
additional information
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UCH-L1 is exclusively expressed in brain and testis
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
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murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis
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UCH-L1 itself is a soluble protein and has no transmembrane domain, but UCH-L1 directly and specifically binds to phosphatidic acid thereby interacting with the menbrane
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wild-type and lipin-2 are present at similar levels in cytosolic and membrane fractions in the absence of oleate
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murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis
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wild-type and lipin-2 are present at similar levels in cytosolic and membrane fractions in the absence of oleate, and it translocates to the membrane fraction with increasing levels of oleate
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UCH-L1 itself is a soluble protein and has no transmembrane domain, but UCH-L1 directly and specifically binds to phosphatidic acid thereby interacting with the menbrane. Monoubiquitin can possibly regulate the interaction between UCH-L1 and phosphatidic acid since bound UCH-L1 is increased in the presence of monoubiquitin
additional information
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GRK1-dependent phosphorylation of cone opsins and binding to cone arrestin leads to association of cone arrestins to the membrane in a light-dependent manner
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additional information
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unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies
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LINKS TO OTHER DATABASES (specific for Mus musculus C57/BL6J)
SILVA: 16S/18S rRNA, 23S/28S rRNA
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Release 2023.1 (January 2023)
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