EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.10 | ATP + [IkappaB protein] |
- |
Canis lupus familiaris |
ADP + [IkappaB phosphoprotein] |
- |
? |
2.7.11.10 | ATP + a protein |
CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + Bcl |
phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling |
Homo sapiens |
ADP + phosphorylated Bcl |
- |
? |
2.7.11.10 | ATP + Bcl |
phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl |
Homo sapiens |
ADP + phosphorylated Bcl |
- |
? |
2.7.11.10 | ATP + Bcl |
Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl |
Homo sapiens |
ADP + phosphorylated Bcl10 |
- |
? |
2.7.11.10 | ATP + Bcl10 |
negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview |
Homo sapiens |
ADP + phosphorylated Bcl10 |
- |
? |
2.7.11.10 | ATP + GST-IkappaBalpha |
activity assay |
Homo sapiens |
ADP + GST-IkappaBalpha phosphoprotein |
- |
? |