EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.14.11.6 | 5-formyluracil + 2-oxoglutarate + O2 |
5-formyluracil reacts subsequently to 5-carboxyuracil |
Neurospora crassa STA 4 |
5-carboxyuracil + succinate + CO2 |
- |
? |
| 1.14.11.6 | thymine + 2-oxoglutarate + 2 O2 |
conversion of thymine to uracil |
Rhodotorula glutinis |
uracil-5-carboxylate + succinate + CO2 + H2O |
three step reaction with 5-hydroxymethyluracil and 5-formyluracil as intermediate products |
? |
| 1.14.11.6 | more |
enzyme is responsible for the local amplification of the unusual DNA base J |
Trypanosoma brucei |
? |
- |
? |
| 1.14.11.6 | more |
enzyme is responsible for the local amplification of the unusual DNA base J |
Leishmania tarentolae |
? |
- |
? |
| 1.14.11.6 | thymine + 2-oxoglutarate + O2 |
i.e. 5-methyluracil |
Neurospora crassa |
5-hydroxymethyluracil + succinate + CO2 |
- |
? |
| 1.14.11.6 | more |
no activity with N1-methyl-5-hydroxymethyluracil, 5-methylcytosine, N3-methyluracil, 6-methyluracil, uracil, 5-carboxyuracil, and thymidine, substrate specificity, overview. Analysis of enzyme reaction products by GC/MS |
Rhodotorula glutinis |
? |
- |
? |
| 1.14.11.6 | thymine + 2-oxoglutarate + O2 |
stereospecific removal of the pro-S hydrogen |
Rhodotorula glutinis |
5-hydroxymethyluracil + succinate + CO2 |
5-hydroxymethyluracil reacts subsequently to 5-formyluracil |
? |
| 1.14.11.6 | more |
the enzyme is a bifunctional helicase and thymine dioxygenase |
Leishmania tarentolae |
? |
- |
? |
| 1.14.11.6 | thymine + 2-oxoglutarate + O2 |
the telomeric repeat sequence GGGTTA is able to stimulate J synthesis, while mutated telomeric sequences (GGGTTT, GGGATT, or GGGAAA) are unable to support J synthesis |
Leishmania major |
5-hydroxymethyluracil + succinate + CO2 |
- |
? |
