EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.315 | 11-cis-retinol + NADP+ |
RDH10 can utilize both NAD+ and NADP+ as cofactors for 11-cis-retinol dehydrogenase activity. NAD+ cofactor confers more robust activity. RDH10 may function in the RPE retinoid visual cycle as an 11-cis-retinol dehydrogenase, and thereby partially compensate for the loss of RDH5 function in human patients with fundus albipunctatus |
Homo sapiens |
11-cis-retinal + NADPH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol + NADP+ |
activity with NAD+ is about 10fold higher than with NADP+ |
Mus musculus |
11-cis-retinal + NADPH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol + NADP+ |
RDH10 can utilize both NAD+ and NADP+ as cofactors for 11-cis-retinol dehydrogenase activity. NAD+ cofactor confers more robust activity |
Homo sapiens |
11-cis-retinal + NADPH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
- |
Bos taurus |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
- |
Homo sapiens |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
- |
Homo sapiens |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ |
- |
r |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
cellular retinaldehyde binding protein CRALBP serves as an 11-cis-retinol acceptor for the enzymatic isomerization of all-trans- to 11-cis-retinol and as a substrate carrier for 11-cis-retinol dehydrogenase RDH5. Altered kinetic parameters are observed for RDH5 oxidation of 11-cis-retinol bound to rCRALBP mutants M222A, M225A, and W244F, supporting impaired substrate carrier function. Data implicate Trp165, Met208, Met222, Met225, and Trp244 as components of the CRALBP ligand binding cavity |
Homo sapiens |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ |
- |
Bos taurus |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ |
- |
Homo sapiens |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[retinal-binding-protein] + NAD+ |
- |
Mus musculus |
11-cis-retinal-[retinol-binding-protein] + NADH + H+ |
- |
? |