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BRENDA support

Information on EC 1.1.1.315 - 11-cis-retinol dehydrogenase

for references in articles please use BRENDA:EC1.1.1.315

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IUBMB Comments

This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal while the substrate is bound to the retinal-binding protein . This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
11-cis-retinol-[retinal-binding-protein]
+
=
11-cis-retinal-[retinol-binding-protein]
+
+

Synonyms
11-cis-retinol dehydrogenase, 11-cis-rdh, crad2, atrdh, 11-cis rd, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
11-cis-retinol-[retinal-binding-protein] + NAD+ = 11-cis-retinal-[retinol-binding-protein] + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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