EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.1.1.153 | more |
the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins |
Rattus norvegicus |
? |
- |
? |
| 1.1.1.153 | more |
the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins |
Rattus norvegicus Sprague-Dawley |
? |
- |
? |
| 1.1.1.153 | more |
the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview |
Homo sapiens |
? |
- |
? |
| 1.1.1.153 | more |
the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview |
Rattus norvegicus |
? |
- |
? |
| 1.1.1.153 | 6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+ |
two reductive steps oxidizing NADPH |
Chlorobaculum tepidum |
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.1.1.153 | L-erythro-dihydroneopterin + NADP+ |
very slow activity, no activity with the D-isomer |
Equus caballus |
? |
- |
r |
| 1.1.1.153 | L-threo-dihydroneopterin + NADP+ |
very slow activity, no activity with the D-isomer |
Equus caballus |
? |
- |
r |
