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Search term: HPAEC cell
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EC Number
Recommended Name
Source Tissue
Commentary
Reference
3.2.1.18
exo-alpha-sialidase
HPAEC cell
-
729983
1.11.1.9
glutathione peroxidase
HPAEC cell
human primary pulmonary artery endothelial cells
673105
4.1.2.27
sphinganine-1-phosphate aldolase
HPAEC cell
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716696
3.4.21.5
thrombin
HPAEC cell
both thrombin and thrombin receptor agonist peptide enhance the permeability barrier of cells, both exhibit a potent barrier protective effect when cells are treated with inactive mutant S195A of protein C prior to stimulation. Thrombin exhibits a potent cytoprotective activity in the lipopolysaccharide-induced permeability and tumor necrosis factor alpha-induced apoptosis and adhesion assays in the protein C mutant S195A treated cells. Treatment with the cholesterol depleting molecule methyl-beta-cyclodextrin eliminates the protective effect
701275
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