EC Number   |
General Information |
Reference |
|---|
   7.6.2.1 | evolution |
ATP-dependent aminophospholipid translocases constitute a subfamily, P4 ATPases, in the superfamily of P-type ATPase pumps |
720856 |
| 7.6.2.1 | evolution |
type IV P-type ATPases, P4-ATPases, are putative phospholipid flippases that translocate phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers and function in complex with CDC50 proteins. Class 5, ATP10A, ATP10B, and ATP10D, and class 6, ATP11A, ATP11B, and ATP11C, P4-ATPases require CDC50 proteins, primarily CDC50A, for their exit from the endoplasmic reticulum and final subcellular localization. In contrast, class 2 P4-ATPases, ATP9A and ATP9B, are able to exit the endoplasmic reticulum in the absence of exogenous CDC50 expression: ATP9B, but not ATP11B, was able to exit the ER despite depletion of CDC50 proteins |
719979 |
| 7.6.2.1 | malfunction |
enzyme deletion suppresses defects of growth and membrane trafficking |
747894 |
| 7.6.2.1 | malfunction |
enzyme depletion delays the recycling of transferrin from endosomes to the plasma membrane and causes accumulation of glucose transporter 1 in endosomes, probably by inhibiting their recycling |
748627 |
| 7.6.2.1 | malfunction |
enzyme mutants show growth defects which are suppressed by depletion of inositol |
-, 749049 |
| 7.6.2.1 | malfunction |
inability of tat-1 mutants to take up 1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine |
721085 |
| 7.6.2.1 | malfunction |
knockdown of ALA1 expression causes a cold-sensitive growth defect in plants |
718993 |
| 7.6.2.1 | malfunction |
mutants defective in genes VPS51, VPS52, VPS53, and VPS54, encoding the Golgi-associated retrograde protein (GARP) complex, the Rab family small GTPase Ypt6p, its guanine nucleotide exchange factor proteins, or Tlg2p t-SNARE, show abberrant intracellular localization of Dnf1p and Dnf2p |
718753 |
| 7.6.2.1 | malfunction |
mutations in the enzyme gene cause progressive familial intrahepatic cholestasis type 1 |
747188 |
| 7.6.2.1 | malfunction |
P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency, and reduced fertility |
718993 |
