EC Number   |
General Information |
Reference |
|---|
   4.1.1.B12 | evolution |
ODC is the major route to polyamine formation in the Chlamydomonas CC-406 cell-wall mutant, in contrast to the preferential ADC route reported for Chlorella vulgaris, suggesting that significant species differences exist in biosynthetic pathways which modulate endogenous polyamine levels in green algae |
-, 749002 |
| 4.1.1.B12 | metabolism |
putrescine is the major polyamine in both free (88%) and membrane-bound fractions (93%) in Chlamydomonas reinhardtii, while norspermidine is the next most abundant in these fractions accounting for 11% and 6%, respectively. Low levels of diaminopropane, spermidine and spermine are also observed although no cadaverine or norspermine are detected. Ornithine decarboxylase (ODC) activity is almost five times higher than arginine decarboxylase (ADC, EC 4.1.1.19) and is the major route of putrescine synthesis. Following exposure to ODC inhibitor alpha-DFMO, the putrescine content in the cells declines, while the norspermidine content increases over 2fold. Addition of norspermidine to cultures stimulates cell division mimicking the effects observed using alpha-DFMO and also reverses the inhibitory effects of cyclohexylamine on growth |
-, 749002 |
| 4.1.1.B12 | metabolism |
the degradation of lysine/ornithine decarboxylase (LDC/ODC) by ATP-requiring protease(s) is accelerated by the binding of Antizyme P22, which is a ribosomal protein of the strain |
748080 |
| 4.1.1.B12 | metabolism |
the enzyme plays a role in the metabolic pathway of lycopodium alkaloid. Lysine decarboxylation is the first biosynthetic step of Huperzine A (HupA) |
748887 |
| 4.1.1.B12 | more |
compared to the activity of lysine/ornithine decarboxylase from Selenomonas ruminantium and lysine decarboxylase from Geobacillus thermodenitrificans, the cadaverine producing activity of enzyme vvLDC is 1.5fold and 5.3fold increased, respectively |
748513 |
| 4.1.1.B12 | more |
compared to the lysine decarboxylase from Geobacillus thermodenitrificans, the cadaverine producing activity of enzyme srLDC is increased, but compared to the lysine/ornithine decarboxylase from Vibrio vulnificus, it is 1.5fold reduced |
748513 |
| 4.1.1.B12 | physiological function |
Nicotiana tabacum hairy roots and Arabidopsis thaliana plants expressing lysine/ornithine decarboxylase show enhanced production of anabasine, and cadaverine, respectively |
748979 |
| 4.1.1.B12 | physiological function |
transgenic tobacco suspension cells and hairy roots expressing lysine decarboxylase produce enhanced levels of cadaverine-derived alkaloids, and transgenic Arabidopsis plants produce enhanced levels of cadaverine, indicating the involvement of this enzyme in lysine decarboxylation to form cadaverine. Enzyme is involved in the decarboxylation of L-Lys, which is the first step of quinolizidine alkaloid biosynthesis in quinolizidine alkaloid-producing plants |
728473 |
