Any feedback?
Information on EC 4.1.1.19 - arginine decarboxylase
for references in articles please use BRENDA:EC4.1.1.19Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
4.1.1.19 arginine decarboxylaseIUBMB Comments
A pyridoxal-phosphate protein.
Specify your search results
Word Map
- 4.1.1.19
- polyamine
- putrescine
- ornithine
- spermidine
- s-adenosylmethionine
- arginase
-
diamine
- samdc
- decarboxylases
- agmatinase
- deiminase
- alpha-difluoromethylornithine
- cadaverine
-
imidazoline
- d-arginine
- pao
-
3.5.3.1
-
iminohydrolase
-
arginine-dependent
-
scots
-
ureohydrolase
- difluoromethylornithine
-
pyrogenic
- drug development
- agriculture
- hyoscyamine
- trifoliata
- poncirus
- speb
-
tropane
- dl-alpha-difluoromethylornithine
- antizyme
- datura
The enzyme appears in viruses and cellular organisms
Synonyms
arginine decarboxylase, spea2, argdc, spea1, biosynthetic arginine decarboxylase, ppadc, atadc2, l-arginine decarboxylase, pyruvoyl-dependent arginine decarboxylase, ptadc, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ADC
ADC1
ADC2
AdiA
ARGDC
arginine decarboxylase
ATADC1
AtADC2
bADC
-
-
-
-
Biosynthetic arginine decarboxylase
CPn1032 homolog
dADC
-
-
-
-
Decarboxylase, arginine
-
-
-
-
HP0422
HVO_1958
L-Arginine decarboxylase
PaADC1
-
expressed in all stages of development, up-regulated in response to chilling or salt stress in seedling stage
PdaD
protein SSO0536
PvlArgDC
pyruvoyl-dependent arginine decarboxylase
SpeA
StADC
Synthetic arginine decarboxylase
-
-
-
-
additional information
ADC
-
-
-
-
ADC
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
-
-
ARGDC
-
-
-
-
Biosynthetic arginine decarboxylase
-
-
-
-
L-Arginine decarboxylase
-
-
-
-
SpeA
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
-
-
additional information
-
the enzyme is a decarboxylase of the AR structural family
additional information
-
the enzyme is a decarboxylase of the AR structural family
additional information
-
the enzyme is a decarboxylase of the AR structural family
additional information
Paramecium bursaria chlorella virus
-
the enzyme belongs to the group IV of pyridoxal 5'-phosphate-dependent decarboxylases belonging to the alpha/beta barrel structural family
additional information
-
the enzyme is a decarboxylase of the AR structural family
additional information
-
the enzyme is a decarboxylase of the AR structural family
additional information
-
the enzyme is a decarboxylase of the AR structural family
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-arginine = agmatine + CO2
-
-
-
-
L-arginine = agmatine + CO2
reaction mechanism via geminal diamine intermediate
L-arginine = agmatine + CO2
the K148-loop movement may be kinetically linked to the rate-limiting step of product release, active site structure, mechanism
Paramecium bursaria chlorella virus
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
decarboxylation
decarboxylation
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
L-arginine carboxy-lyase (agmatine-forming)
A pyridoxal-phosphate protein.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9024-77-5
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-N5-(iminoethyl)-ornithine
N1-(2-iminoethyl)-butane-1,4-diamine + CO2
-
-
-
-
?
N-omega-nitro-L-arginine methyl ester
methyl formate + 1-(4-amino-5,5-difluoropentyl)guanidine + CO2
difluoromethylornithine
1-(4-amino-5,5-difluoropentyl)guanidine + CO2
over 90% activity compared to L-arginine
-
-
?
difluoromethylornithine
1-(4-amino-5,5-difluoropentyl)guanidine + CO2
Helicobacter pylori ATCC 700392 / 26695
over 90% activity compared to L-arginine
-
-
?
L-Arg
?
-
cAMP receptor protein controls arginine decarboxylase expression by inhibiting the activity of the enzyme indirectly and putrescine represses the gene at the level of transcription
-
-
?
L-Arg
?
-
2 enzyme forms: a biosynthetic arginine decarboxylase and a degradative arginine decarboxylase. The physiological role of the degradative arginine decarboxylase possibly is the regulation of the environmental pH
-
-
?
L-Arg
?
-
the biosynthetic arginine decarboxylase is the first of two enzymes in a putrescine biosynthetic pathway
-
-
?
L-Arg
?
-
higher activity in plants cultivated on ammonium chloride than in plants grown on nitrate
-
-
?
L-Arg
?
-
agmatine production by the mitochondria could serve as a protective mechanism against cytotoxicity from excessive nitric oxide formation
-
-
?
L-Arg
?
-
possibly active in biosynthesis of polyamines required for growth by expansion and differentiation or in synthesis of alkaloids from putrescine
-
-
?
L-Arg
?
-
possibly active in biosynthesis of polyamines required for growth by expansion and differentiation or in synthesis of alkaloids from putrescine
-
-
?
L-arginine
agmatine + CO2
-
the ADC2 gene is the only gene of polyamine biosynthesis involved in wounding response mediated by methyl jasmonate. A transient increase in the level of free putrescine follows the increase in the mRNA level for ADC2
-
-
?
L-arginine
agmatine + CO2
amino acids K136 and C524 of ADC1 are essential for activity and participate in separate active sites
-
-
?
L-arginine
agmatine + CO2
-
key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine, plays a role in stress response, mutants spe1-1 and spe2-1 have a lower salt tolerance than the wild type plant
-
-
?
L-arginine
agmatine + CO2
-
rate limiting and key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine, induced in response to salt stress
-
-
?
L-arginine
agmatine + CO2
-
key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine, plays a role in abiotic stress response
-
-
?
L-arginine
agmatine + CO2
-
key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine, plays a role in stress response
-
-
?
L-arginine
agmatine + CO2
first reaction of a putrescine synthetic pathway found in bacteria and plants
-
-
?
L-arginine
agmatine + CO2
-
the enzyme is involved in the biosynthesis of putrescine, which is the precursor of other polyamines in animals, plants, and bacteria
-
-
?
L-arginine
agmatine + CO2
-
key enzyme in the biosynthesis of polyamines, key enzyme in the biosynthesis of putrescine and the subsequent synthesis of spermine and spermidine, plays a role in response to mechanical wounding
-
-
?
L-arginine
agmatine + CO2
-
the enzyme is involved in the biosynthesis of putrescine, which is the precursor of other polyamines in animals, plants, and bacteria
-
-
?
L-arginine
agmatine + CO2
-
the enzyme is involved in the biosynthesis of putrescine, which is the precursor of other polyamines in animals, plants, and bacteria
-
-
?
L-arginine
agmatine + CO2
-
key enzyme in the biosynthesis of polyamines, primarily responsible for the biosynthesis of putrescine in non-dividing elongation cells, plays a role in stress response
-
-
?
L-arginine
agmatine + CO2