EC Number   |
General Information |
Reference |
|---|
    3.5.4.9 | metabolism |
the enzyme is involved in folate pathway. It is involved in mitochondrial NADPH production |
756334 |
| 3.5.4.9 | metabolism |
the enzyme plays a central role in folate homeostasis and serve as targets for antibacterials |
743250 |
| 3.5.4.9 | metabolism |
the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase(MTHFD2)-controlled cluster redirects metabolism to glycine synthesis to replenish purine nucleotides. Since endothelial cells secrete purines in response to oxPAPC, the MTHFD2-controlled response maintains endothelial ATP. Accordingly, MTHFD2-dependent glycine synthesis is a prerequisite for angiogenesis. It is proposed that endothelial cells undergo MTHFD2-mediated reprogramming toward serine-glycine and mitochondrial one-carbon metabolism to compensate for the loss of ATP in response to oxidized phospholipids during atherosclerosis |
757773 |
| 3.5.4.9 | metabolism |
three enzyme activities in the protozoan Leishmania major, namely N5,N10-methylenetetrahydrofolate dehydrogenase/N5,N10-methenyltetrahydrofolate cyclohydrolase and N10-formyltetrahydrofolate ligase produce the essential intermediate N10-formyltetrahydrofolate, folate metabolism pathway, overview |
-, 720406 |
| 3.5.4.9 | more |
active site structure, overview |
-, 720406 |
| 3.5.4.9 | more |
structure of the TaMTHFDC-NADP+ complex dimer, overview |
718743 |
