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Literature summary for 3.5.4.9 extracted from

  • Aluri, S.; Sah, S.; Miryala, S.; Varshney, U.
    Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli (2016), Microbiology, 162, 145-155 .
    View publication on PubMed
Search for more literature for 3.5.4.9

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 Clostridium perfringens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.157
-
 (6R,S)-5,10-methenyltetrahydrofolate pH 7.6, temperature not specified in the publication Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens A0A2X2Y2S3
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Clostridium perfringens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6R,S)-5,10-methenyltetrahydrofolate + H2O
-
 Clostridium perfringens 10-formyltetrahydrofolate
-
 ?

Synonyms

Synonyms Comment Organism
5,10-CH+-THF cyclohydrolase
-
 Clostridium perfringens
FchA
-
 Clostridium perfringens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Clostridium perfringens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Clostridium perfringens

General Information

General Information Comment Organism
metabolism the enzyme plays a central role in folate homeostasis and serve as targets for antibacterials Clostridium perfringens