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Information on EC 3.5.4.9 - methenyltetrahydrofolate cyclohydrolase

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IUBMB Comments
In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase (EC 1.5.1.5) activity or formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
cyclohydrolase, mthfd2, 5,10-methenyltetrahydrofolate cyclohydrolase, 5,10-methenyl-thf cyclohydrolase, mthfd2l, nad-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, dhch1, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase, 5,10-methenyl-h4folate cyclohydrolase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate
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