EC Number   |
General Information |
Reference |
|---|
   3.5.1.98 | evolution |
GmHDACs fall into three major groups previously named RPD3/HDA1, SIR2, and HD2, phylogenetic analysis. Chromosomal localization and duplications of HDAC genes in soybean, overview |
756309 |
| 3.5.1.98 | evolution |
histone deacetylase 8 (HDAC8) is a member of the class I acetyl-lysine deacetylase (HDAC) family |
756047 |
| 3.5.1.98 | evolution |
human histone deacetylases belong to all three known classes, class I: HDAC1, HDAC2, HDAC3, HDAC8, class II: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10, and class III: HDAC11 |
756269 |
| 3.5.1.98 | evolution |
Set3C is a conserved nuclear complex, Set3 interacts with Hos2 |
735000 |
| 3.5.1.98 | evolution |
the enzyme belongs to the histone deacetylase (HDAC) superfamily |
-, 756043 |
| 3.5.1.98 | evolution |
the enzyme belongs to the RPD3/HDA1-like superfamily of histone deacetylases (HDACs) |
756812 |
| 3.5.1.98 | evolution |
the protruded arm regions are conserved among the Hda1 homologies, and residues Ile512, Ile523 and Leu525 that play key role in the domain-domain interaction are relatively conserved. The ARB2 domain of Hda1 shows structural similarity to the alpha/beta fold hydrolases |
-, 758377 |
| 3.5.1.98 | malfunction |
alkylation (carbonylation) of conserved cysteine residues in HDAC1, -2 and -3 antagonizes their deacetylase activity and transcriptional co-repressor function |
712434 |
| 3.5.1.98 | malfunction |
deletion of Hos2, the catalytic subunit of the Set3 complex, produces a phenotype resembling inhibition of the Set3C by trichostatin-A |
-, 733817 |
| 3.5.1.98 | malfunction |
depleting maternal isozyme HDAC2 results in hyperacetylation of H4K16, while normal deacetylation of other lysine residues of histone H3 or H4 is observed, and defective chromosome condensation and segregation during oocyte maturation occurs in a subpopulation of oocytes, leading to increased incidence of aneuploidy likely accounts for the observed sub-fertility of mice harboring Hdac2-defective oocytes. The infertility of mice harboring Hdac1-/+/Hdac2-/- oocytes is attributed to failure of those few eggs that properly mature to metaphase II to initiate DNA replication following fertilization. Hdac1-/+/Hdac2-/- eggs are fertilized but fail to initiate DNA replication. The increased amount of acetylated H4K16 likely impairs kinetochore function in oocytes lacking isozyme HDAC2 because kinetochores in mutant oocytes are less able to form coldstable microtubule attachments and less CENP-A is located at the centromere. Phenotype, overview |
735001 |
