EC Number   |
General Information |
Reference |
|---|
   3.4.21.5 | malfunction |
high glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, which may play an important role in the vascular complications of diabetes |
717167 |
| 3.4.21.5 | malfunction |
in the transgenic TRAMP mouse model of prostate cancer inhibition of endogenous thrombin by hirudin retards spontaneous tumor growth. Inhibition of thrombin may lead to tumor dormancy |
708032 |
| 3.4.21.5 | metabolism |
PAR-1 signaling to NF-kappaB in endothelial cells via protein kinase C signaling, CARMA3/Bcl10/MALT1, CBM, signalosome, and IkappaB kinase, and involving thrombin, pathway regulation, overview. The CBM signalosome controls thrombin-dependent monocyte/endothelial adhesion. The process is different in lymphocytes where CARMA1 is active instead of CARMA3 |
717814 |
| 3.4.21.5 | metabolism |
thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in human lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. Treatment of cells with thrombin causes activation of Rac and Akt. Thrombin induces NF-kappaB activation and protein expression through multiple signaling pathways such as PKCalpha/c-Src, Rac1, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, IkappaB kinases, and PI3K/Akt, overview |
717817 |
| 3.4.21.5 | metabolism |
thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. Treatment of cells with thrombin causes activation of Rac and Akt. Thrombin induces NF-kappaB activation and protein expression through multiple signaling pathways such as PKCalpha/c-Src, Rac1, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, IkappaB kinases, and PI3K/Akt, overview |
717817 |
| 3.4.21.5 | more |
peptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds displaying length- and sequence-dependent antimicrobial, e.g. against Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, the Gram-positive bacterium Staphylococcus aureus, and the fungus Candida albicans, as well as immunomodulating effects. A peptide length of at least 20 amino acids is required for effective anti-inflammatory effects in macrophage models, as well as optimal antimicrobial activity |
717098 |
| 3.4.21.5 | more |
the thrombin catalytic triad comprises residues His57, Asp102, and Ser195 |
718297 |
| 3.4.21.5 | more |
thrombin and trypsin directly activate vagal C-fibres in C57BL6 mouse lung via protease-activated receptor-1,i.e. PAR1, not via PAR3, PAR2, and PAR4, overview |
718033 |
| 3.4.21.5 | physiological function |
after treating JR-FL Env-expressing 293T cells with various concentrations of thrombin and subsequent coculture for 14 h, thrombin effect turns out to be a concentration-dependent fusion enhancement, thrombin can enhance the fusion mediated by R5-tropic HIV-1 gp160 |
707386 |
| 3.4.21.5 | physiological function |
HUVEC cells stimulated with thrombin (10 nM) exhibit an increased amount of actin filaments (show increased cell stiffness) when compared to unstimulated cells |
709588 |
