Literature summary for 3.4.21.5 extracted from

Kasetty, G.; Papareddy, P.; Kalle, M.; Rydengard, V.; Moergelin, M.; Albiger, B.; Malmsten, M.; Schmidtchen, A.
Structure-activity studies and therapeutic potential of host defense peptides of human thrombin (2011), Antimicrob. Agents Chemother., 55, 2880-2890.

Search for more literature for 3.4.21.5

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
additional information	peptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds displaying length- and sequence-dependent antimicrobial, e.g. against Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, the Gram-positive bacterium Staphylococcus aureus, and the fungus Candida albicans, as well as immunomodulating effects. A peptide length of at least 20 amino acids is required for effective anti-inflammatory effects in macrophage models, as well as optimal antimicrobial activity	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)