EC Number   |
General Information |
Reference  |
|---|
   3.4.21.117 | malfunction |
KLK7 is upregulated in epithelial ovarian carcinoma with high levels correlated with poor prognosis. Mechanism for association of high KLK7 levels with chemoresistance and poor prognosis for serous EOC patients by promotion of peritoneal dissemination and reinvasion via increased MCA and alpha5beta1 integrin-dependent cell adhesion |
707990 |
| 3.4.21.117 | malfunction |
kallikrein 7 may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion |
708770 |
| 3.4.21.117 | physiological function |
kallikrein 7 is a proteolytic enzyme important for epithelial cell shedding |
708770 |
| 3.4.21.117 | physiological function |
the serine proteases kallikrein 5 and kallikrein 7 control enzymatic processing of cathelicidin precursor in the skin and regulate the eventual function of the final forms of these peptides |
709408 |
| 3.4.21.117 | evolution |
human kallikrein-related peptidase 7 is one member from a cluster of 15 serine peptidases of the chymotrypsin-like S1A family clan PA(S) sharing a high degree of identity and localized at human chromosome locus 19q13.4 |
731367 |
| 3.4.21.117 | physiological function |
the enzyme plays roles in physiological and pathological skin desquamation processes that requires the presence of water in the stratum corneum, which is maintained by hygroscopic compounds collectively named as skin moisturizing factor |
731367 |
| 3.4.21.117 | physiological function |
serine proteases of the tissue kallikrein-related peptidases family are implicated in tumorigenesis, kallikrein-related peptidase 7 is a proliferative factor that is aberrantly expressed in human colon cancer and involved in cell proliferation in vitro and in vivo |
731402 |
| 3.4.21.117 | physiological function |
the treatment of beta-amyloid oligomer preparations with the enzyme, but not the inactive proform, significantly reduces Abeta42-mediated toxicity to rat hippocampal neurons to the same extent as the known Abeta-degrading protease insulin-degrading enzyme |
731403 |
| 3.4.21.117 | evolution |
human tissue kallikrein-7 is a chymotryptic serine protease member of tissue kallikrein family. |
731754 |
| 3.4.21.117 | physiological function |
the enzyme is involved in skin homeostasis and inflammation. Excess of enzyme activity is also associated with tumor metastasis processes, especially in ovarian carcinomas, prostatic and pancreatic cancers |
731754 |
