EC Number |
General Information |
Reference |
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3.1.1.7 | evolution |
as one of the most ancient true cholinesterases, DjChE provides insight into the evolution of a hybrid enzyme before the separation into distinct AChE and BChE enzymes found in higher vertebrates |
749765 |
3.1.1.7 | evolution |
isozymes PrAChE1 and PrAChE2 both have features typical of AChEs, including the catalytic triad, choline-binding sites, an oxyanion hole, an acyl pocket, a peripheral anionic subsite, an FGESAG motif and 14 conserved aromatic amino acids. Phylogenetic analysis shows that Prace1 and Prace2 are clustered into two distinct groups: ace1 and ace2, respectively |
751267 |
3.1.1.7 | evolution |
key amino acid differences at functional sites among AChEs of Torpedo californica, Tetranychus urticae, and Pardosa pseudoannulata, evolutionary relationships, overview |
743326 |
3.1.1.7 | evolution |
the bed bug uniquely possesses three genes encoding different cholinesterase (ChE) types [AChE1, AChE2 and salivary gland-specific cholinesterase (SChE)]. According to phylogenetic analysis, all three bed bug ChEs are categorized into a large clade of invertebrate ChEs. ClAChE1 is classified into the insect AChE1-type clade, whereas ClAChE2 is categorized into the insect AChE2-type clade. ClSChE is categorized into the clade containing the nematode and arachnid AChE1, which is closely located in an insect AChE1-type clade |
750745 |
3.1.1.7 | malfunction |
Alzheimer's disease, a neurodegenerative disease characterized by a low concentration of acetylcholine in the hippocampus and cortex, is the leading cause of dementia among older people |
710187 |
3.1.1.7 | malfunction |
compound C547 and pyridostigmine bromide show efficiency to reduce muscle weakness symptoms and ability to activate contractions of urinary bladder in a rat model of autoimmune myasthenia gravis (MG). At a dose effectively reducing MG symptoms, C547 does not affect activity of rat urinary bladder, while at equipotent dose, pyridostigmine causes a significant increase in tonus and force of spontaneous contractions of bladder wall. In contrast, almost complete inhibition of butyrylcholinesterase (BChE, EC 3.1.1.8) does not affect either the force of contractions or tonus of EAMG rat bladders in vivo |
752242 |
3.1.1.7 | malfunction |
compound C547 and pyridostigmine bromide show efficiency to reduce muscle weakness symptoms and ability to activate contractions of urinary bladder in autoimmune myasthenia gravis (MG) treatment. At a dose effectively reducing MG symptoms, C547 does not affect activity of human urinary bladder, while at equipotent dose, pyridostigmine causes a significant increase in tonus and force of spontaneous contractions of bladder wall |
752242 |
3.1.1.7 | malfunction |
DjChE inhibition affects planarian behavior, inhibitors delay the reaction of planarians to heat stress. Simultaneous knockdown of both Djche genes by RNAi similarly results in a delayed heat stress response. Chemical inhibition of DjChE activity increases the worms' ability to adhere to a substrate. But increased substrate adhesion is not observed in Djche1/Djche2 (RNAi) animals or in inhibitor-treated day 11 regenerates, suggesting this phenotype may be modulated by other mechanisms besides ChE inhibition |
749766 |
3.1.1.7 | malfunction |
negative effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat |
-, 749749 |
3.1.1.7 | malfunction |
silencing of Tcace1 and Tcace2 by RNA interference significantly increases the susceptibility of Toxoptera citricidus to malathion and carbaryl, silencing of isozyme Tcace1 results in a higher mortality rate than silencing of isozyme Tcace2. Additionally, the specific enzyme activity decreases more after silencing Tcace1 than after silencing Tcace2 |
751802 |