Literature summary for 3.1.1.7 extracted from

Hagstrom, D.; Zhang, S.; Ho, A.; Tsai, E.S.; Radic, Z.; Jahromi, A.; Kaj, K.J.; He, Y.; Taylor, P.; Collins, E.S.
Planarian cholinesterase molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity (2018), Arch. Toxicol., 92, 1161-1176 .

Search for more literature for 3.1.1.7

Cloned(Commentary)

Cloned (Comment)	Organism
Djche1 and Djche2, sequence comparisons	Dugesia japonica

Protein Variants

Protein Variants	Comment	Organism
additional information	Djche1 and Djche2 knockdown by dsRNA and RNAi	Dugesia japonica

Inhibitors

Inhibitors	Comment	Organism	Structure
diazinon	-	Dugesia japonica
additional information	inhibition of DjChE activity by exposing animals to either an organophosphorus pesticides (e.g. diazinon) or carbamates (e.g. physostigmine). At high doses, organophosphorus pesticides are lethal to both insects and humans due to inhibition of AChE and subsequent cholinergic toxicity	Dugesia japonica
physostigmine	-	Dugesia japonica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetylcholine + H2O	Dugesia japonica	-	choline + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Dugesia japonica	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	expression patterns of Djche1 and Djche2	Dugesia japonica	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylcholine + H2O	-	Dugesia japonica	choline + acetate	-	?
additional information	the Dugesia japonica enzyme DjChE has intermediate features of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE, EC 3.1.1.8). Two candidate genes, Djche1 and Djche2, are responsible for DjChE activity	Dugesia japonica	?	-	?

Synonyms

Synonyms	Comment	Organism
Djche1	-	Dugesia japonica
Djche2	-	Dugesia japonica
More	cf. EC 3.1.1.8	Dugesia japonica
planarian cholinesterase	-	Dugesia japonica

General Information

General Information	Comment	Organism
malfunction	DjChE inhibition affects planarian behavior, inhibitors delay the reaction of planarians to heat stress. Simultaneous knockdown of both Djche genes by RNAi similarly results in a delayed heat stress response. Chemical inhibition of DjChE activity increases the worms' ability to adhere to a substrate. But increased substrate adhesion is not observed in Djche1/Djche2 (RNAi) animals or in inhibitor-treated day 11 regenerates, suggesting this phenotype may be modulated by other mechanisms besides ChE inhibition	Dugesia japonica
additional information	Djche1 and Djche2 enzyme structure homology modelling using Torpedo californica AChE as the template (PDB IDs 2cek and 2w6c, respectively)	Dugesia japonica

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Release 2023.1 (January 2023)