EC Number   |
General Information |
Reference |
|---|
   2.8.2.8 | evolution |
four NDST isoforms are present in humans |
760624, 760812 |
| 2.8.2.8 | evolution |
four NDST isoforms are present in the human. NDST-1 is the most widely distributed isoform in tissues and organisms, and is considered to exhibit profound physiological functions during all stages of human development |
760624 |
| 2.8.2.8 | malfunction |
a complete lack of NDST1 results in an inability to synthesize HS glycan chains, which is ultimately lethal |
760812 |
| 2.8.2.8 | malfunction |
heparan sulfate (HS) is a sulfated polysaccharide that plays a key role in morphogenesis, physiology and pathogenesis. The biosynthesis of HS takes place in the Golgi apparatus by a group of enzymes that polymerize, epimerize and sulfate the sugar chain. This biosynthetic process introduces varying degrees of sulfate substitution, which are tightly regulated and directly dictate binding specificity to different cytokines, morphogens and growth factors. Molecular dynamics simulations to investigate the dynamics of substrate recognition of two glycosaminoglycan (GAG) sulfotransferases, N-deacetylase-N-sulfotransferase and 2-O-sulfotransferaseto the HS chain during the biosynthetic process. Fine-tuned complex mechanism of GAG biosynthesis |
761218 |
| 2.8.2.8 | malfunction |
selective deletion of heparan sulfotransferase enzyme, Ndst1, in donor endothelial and myeloid precursor cells significantly decreases acute allograft rejection, overview. Ndst1 deficiency in donor renal allografts significantly reduces histopathological markers for early renal allograft rejection. M-T7 (Myxomavirus-derived secreted glycoprotein that possesses a broad spectrum, species-independent, C, CC and CXC chemokine inhibitory activity) treatment significantly reduces histopathological markers for renal allograft rejection. M-T7 and M-T7 point mutant treatment have variable efficacy in WT and Ndst1-/- allografts. Reduced HS and chemokine immunoreactivity is associated with reduced rejection |
-, 762448 |
| 2.8.2.8 | malfunction |
the absence of both isoforms Ndst1 and Ndst2 induces increased branching of the ductal epithelium in mammary gland. Ndst-deficient ducts display an apparent overabundance of branched ductal epithelia and cellular chimerism in the level of sulfated cell surface heparan sulfate |
725501 |
| 2.8.2.8 | metabolism |
in the general scheme of heparan sulfate biosynthesis, GlcNAc N-deacetylation and N-sulfation by NDSTs create the prerequisite substrate needed for the next enzymatic modifications |
704666 |
| 2.8.2.8 | metabolism |
NDST-2 is the first and a key enzyme in heparin synthesis, with the following modifications being dependent on the reactions catalyzed by the NDSTs |
-, 704949 |
| 2.8.2.8 | metabolism |
the enzymes is involved in heparan sulfate biosynthesis. EXT1, NDST1, and NDST2 differentially regulate heparan sulfate biosynthesis in human tooth germ |
759255 |
| 2.8.2.8 | more |
analysis of the mode of action of NDST-4 |
760624 |
