EC Number   |
General Information |
Reference |
|---|
   2.7.7.7 | drug target |
R61 and S62 play key roles in the specificity and effectiveness of DNA polymerase eta for bypassing TTD lesions during DNA replication. Understanding the basis for this specificity is important for designing drugs aimed at cancer treatment |
761729 |
| 2.7.7.7 | drug target |
the enzyme is a viable antimalarial drug target |
761693 |
| 2.7.7.7 | drug target |
the enzyme is an attractive target for cancer therapies because it has been correlated with a shorter survival time in patients with glioblastoma as well as poor chemotherapy responses in some cases |
761958 |
| 2.7.7.7 | evolution |
a self-activated mechanism for efficient polymerase catalysis is proposed, which is based on the identification of an evolutionary convergence to preserve a key enzymatic structural element in all the available X-ray structures of DNA/RNA polymerases from all domains of life |
761347 |
| 2.7.7.7 | evolution |
compared to mammalian pol betas, the Danio rerio enzyme contains a P63D amino acid substitution. This substitution lies in a hairpin sequence within an 8-kDa domain, likely to be important in DNA binding |
723110 |
| 2.7.7.7 | evolution |
DNA polymerase I belongs to the DNA polymerase family A, all the functionally important regions in the polymerase active site of Geobacillus kaue polI are conserved, phylogenetic analysis, evolutionary relationship of diverse Geobacillus species, overview |
-, 721308 |
| 2.7.7.7 | evolution |
DNA polymerase ny is a conserved family A DNA polymerase |
723694 |
| 2.7.7.7 | evolution |
human DNA polymerase lambda is a member of the DNA polymerase X family |
721129 |
| 2.7.7.7 | evolution |
K4PolI is a family A DNA polymerase, phylogenetic tree |
-, 722837 |
| 2.7.7.7 | evolution |
the catalytic subunits Pol1, Pol2 and Pol3 or isozymes pol alpha, pol epsilon, and pol delta are phylogenetically related, and belong to the class B DNA polymerases. The B subunits are all essential and share a phosphodiesterase-like and oligosaccharide binding domain. Eukaryotes contain a fourth class B DNA polymerase, Pol zeta, which is the major enzyme responsible for mutagenesis in response to DNA damage |
-, 723249 |
