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Literature summary for 2.7.7.7 extracted from

  • Milton, M.E.; Choe, J.Y.; Honzatko, R.B.; Nelson, S.W.
    Crystal structure of the apicoplast DNA polymerase from Plasmodium falciparum the first look at a plastidic A-family DNA polymerase (2016), J. Mol. Biol., 428, 3920-3934 .
    View publication on PubMed
Search for more literature for 2.7.7.7

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drops method, crystal structure at a resolution of 2.9 A Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast
-
 Plasmodium falciparum 20011
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Plasmodium falciparum
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8ILY1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
-
 Plasmodium falciparum diphosphate + DNAn+1
-
 ?

General Information

General Information Comment Organism
drug target the enzyme is a viable antimalarial drug target Plasmodium falciparum