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Literature summary for 2.7.7.7 extracted from

  • Ucisik, M.N.; Hammes-Schiffer, S.
    Effects of active site mutations on specificity of nucleobase binding in human DNA polymerase eta (2017), J. Phys. Chem. B, 121, 3667-3675 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Protein Variants

Protein Variants Comment Organism
R61A the mutations decreases the ability of the enzyme to distinguish between a thymine-thymine dimer lesion and undamaged DNA. Mutation does not impact the global structure and equilibrium motions of DNA polymerase eta. Only local conformational changes around the mutation sites are observed Homo sapiens
R61K the mutations decreases the ability of the enzyme to distinguish between a thymine-thymine dimer lesion and undamaged DNA. Mutation does not impact the global structure and equilibrium motions of DNA polymerase eta. Only local conformational changes around the mutation sites are observed Homo sapiens
S62A the mutations decreases the ability of the enzyme to distinguish between a thymine-thymine dimer lesion and undamaged DNA. Mutation does not impact the global structure and equilibrium motions of DNA polymerase eta. Only local conformational changes around the mutation sites are observed Homo sapiens
S62L the mutations decreases the ability of the enzyme to distinguish between a thymine-thymine dimer lesion and undamaged DNA. Mutation does not impact the global structure and equilibrium motions of DNA polymerase eta. Only local conformational changes around the mutation sites are observed Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y253
-
-

Synonyms

Synonyms Comment Organism
DNA polymerase eta
-
 Homo sapiens
Pol eta
-
 Homo sapiens

General Information

General Information Comment Organism
drug target R61 and S62 play key roles in the specificity and effectiveness of DNA polymerase eta for bypassing TTD lesions during DNA replication. Understanding the basis for this specificity is important for designing drugs aimed at cancer treatment Homo sapiens
physiological function DNA polymerase eta plays a vital role in protection against skin cancer caused by damage from ultraviolet light. The enzyme rescues stalled replication forks at cyclobutane thymine-thymine dimers (TTDs) by inserting nucleotides opposite these DNA lesions Homo sapiens