EC Number   |
General Information |
Reference |
|---|
    2.7.1.21 | evolution |
the thymidine kinase 1 reaction belongs to the pyrimidine salvage route that is phylogenetically conserved |
760008 |
| 2.7.1.21 | malfunction |
a mutation in the thymidine kinase gene results in a shortened enzyme incapable of E-5-(2-bromovinyl)-2'-deoxyuridine phosphorylating |
-, 723766 |
| 2.7.1.21 | malfunction |
depletion of thymidine kinase 1 decreases the efficiency of DNA repair during recovery from DNA damage and generates more cell death |
722681 |
| 2.7.1.21 | malfunction |
isoform TK2-deficient animal show growth retardation and premature death |
723301 |
| 2.7.1.21 | malfunction |
the thymidine kinase-deletion mutant WA79DELTATK shows more than 20fold increase in sensitivity towards acyclovir and is insensitive to ganciclovir |
-, 701752 |
| 2.7.1.21 | malfunction |
TK1a/TK1b double mutants die at an early stage |
722246 |
| 2.7.1.21 | malfunction |
Zea mays L. has a single thymidine kinase TK1 (ZmTK1) gene and mutant plants are albino and display reduced genome copy number in chloroplasts |
760008 |
| 2.7.1.21 | physiological function |
the enzyme is involved in the salvage pathway of DNA synthesis and its activity is correlated with cell proliferation |
758947 |
| 2.7.1.21 | physiological function |
the enzyme plays a crucial role in DNA synthesis and cell proliferation |
758984 |
| 2.7.1.21 | physiological function |
the virus-encoded thymidine kinase is an important determinant of the virus susceptibility to nucleoside analogues |
-, 701752 |
