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Literature summary for 2.7.1.21 extracted from

  • Najera-Martinez, M.; Pedroza-Garcia, J.A.; Suzuri-Hernandez, L.J.; Mazubert, C.; Drouin-Wahbi, J.; Vazquez-Ramos, J.; Raynaud, C.; Plasencia, J.
    Maize thymidine kinase activity is present throughout plant development and its heterologous expression confers tolerance to an organellar DNA-damaging agent (2020), Plants (Basel), 9, 930 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Zea mays

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast translocation to chloroplasts depends on a 72-amino-acid N-signal Zea mays 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + thymidine Zea mays pyrimidine salvage route ADP + dTMP
-
 ?

Organism

Organism UniProt Comment Textmining
Zea mays B0R217
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Zea mays
-
leaf
-
 Zea mays
-
pollen low activity Zea mays
-
seedling
-
 Zea mays
-
stem highest activity Zea mays
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
 Zea mays ADP + dTMP
-
 ?
ATP + thymidine pyrimidine salvage route Zea mays ADP + dTMP
-
 ?

Synonyms

Synonyms Comment Organism
thymidine kinase 1
-
 Zea mays
TK1
-
 Zea mays

General Information

General Information Comment Organism
evolution the thymidine kinase 1 reaction belongs to the pyrimidine salvage route that is phylogenetically conserved Zea mays
malfunction Zea mays L. has a single thymidine kinase TK1 (ZmTK1) gene and mutant plants are albino and display reduced genome copy number in chloroplasts Zea mays
physiological function thymidine kinase 1 (TK1) functions in monocot species as an organellar enzyme for genome replication and repair. ZmTK1 transcripts and activity are present during germination and throughout maize development Zea mays