EC Number   |
General Information |
Reference  |
|---|
   2.7.1.159 | malfunction |
required for proper development of the neural tube and axial mesoderm |
-, 701020 |
| 2.7.1.159 | physiological function |
T-DNA insertion in a gene encoding a putative inositol 1,3,4-trisphosphate 5/6-kinase, i.e. ITPK2, dsm3, leads to a drought- and salt-hypersensitive mutant. Under drought stress conditions, the mutant has significantly less accumulation of osmolytes such as proline and soluble sugar and shows significantly reduced root volume, spikelet fertility, biomass, and grain yield with concomittant increase in malondialdehyde level Overexpression of DSM3 in rice results in drought- and salt-hypersensitive phenotypes and physiological changes similar to those in the mutant. Inositol trisphosphate level is decreased in the overexpressors under normal condition and drought stress |
723438 |
| 2.7.1.159 | malfunction |
the epidermis structure of seed coat is irregularly formed in seeds of itpk2-1 mutant, resulting in the increased permeability of seed coat to tetrazolium salts. The cell wall shows a dramatic decrease in composition of suberin and cutin, which relate to the permeability of seed coat and the formation of which is accompanied with seed coat development. ITPK2 deficiency results in the distorted seed coat and crumpled columellas. Seed coat of itpk2-1 mutant presents high permeability to 2,3,5-triphenyltetrazolium and has less mucilage |
737332 |
| 2.7.1.159 | physiological function |
enzyme ITPK2 plays an essential role in seed coat development and lipid polyester barrier formation |
737332 |
| 2.7.1.159 | malfunction |
loss of this gene in itpk3-1 does neither affect phytate seed levels, nor seed Zn, Fe, and Mn but the micronutrient bioavailability is strongly reduced by seed phytate that forms complexes with seed cations. Low seed zinc is primarily caused by plant growth in Zn-deficient soil |
-, 738303 |
| 2.7.1.159 | metabolism |
measurement of Fe, Zn, and Mn concentrations in seeds of Arabidopsis thaliana accessions grown in Zn-deficient and Zn-amended conditions, overview. Inositol 1,3,4-trisphosphate 5/6-kinase 3 gene (ITPK3), located close to a significant nucleotide polymorphism associated with relative Zn seed concentrations, is dispensable for seed micronutrients accumulation in ecotype Col-0 |
-, 738303 |
| 2.7.1.159 | evolution |
phylogenetic tree showing the evolutionary relatedness of GmITPK2 with ITPKs of monocot and dicot species using Entamoeba histolytica (EhITPK) as an outgroup member |
760244 |
| 2.7.1.159 | metabolism |
following the formation of myo-inositol-3-phosphate, sequential phosphorylation reactions via action of various inositol phosphate kinases-myo-inositol kinase (Mik), inositol 1,3,4-trisphosphate kinase (Itpk), inositol 1,4,5-trisphosphate 3/6 kinase (Ipk2), and inositol 1,3,4,5,6-pentakisphosphate kinase (Ipk1) lead to phytic acid (PA, myo-inositol 1,2,3,4,5,6-hexakisphosphate) synthesis via the lipid-independent pathway and fine-tune the phosphorous flux towards PA accumulation |
760244 |
| 2.7.1.159 | more |
enzyme homology-based modeling and structure comparisons, overview. Active site mapping and molecular docking with ATP |
760244 |
| 2.7.1.159 | physiological function |
inositol 1,3,4-trisphosphate kinase-2 (GmItpk2), catalyzing the ATP-dependent phosphorylation of inositol 1,3,4-trisphosphate (IP3) to inositol 1,3,4,5-tetraphosphate or inositol 1,3,4,6-tetraphosphate, is a key enzyme diverting the flux of inositol phosphate pool towards phytate biosynthesis |
760244 |
