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Information on EC 2.7.1.159 - inositol-1,3,4-trisphosphate 5/6-kinase
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2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinaseIUBMB Comments
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus . Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) . The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase.
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Word Map
- 2.7.1.159
-
phytic
- polyphosphate
-
hexakisphosphate
- dehydration
-
itpks
-
2-kinase
- phosphorus
- pentakisphosphate
-
signalosome
-
lipid-independent
-
tnfalpha-induced
- 1,3,4,5,6-pentakisphosphate
-
monophosphatase
-
photomorphogenesis
-
1,4,5-tris-phosphate
- 1,3,4,6-tetrakisphosphate
- phytate
- imp
- ikappabalpha
-
atp-grasp
- agriculture
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
5/6-kinase, gmitpk2, ositl1, atitpk4, 5/6 kinase, at2g43980, inositol 1,3,4-triphosphate 5/6-kinase, inositol 1,3,4 trisphosphate kinase-2, inositol-1,3,4-trisphosphate 5/6-kinase, inositol-1,3,4-trisphosphate kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
inositol 1,3,4-triphosphate 5/6-kinase
inositol 1,3,4-trisphosphate 5/6-kinase
Ins(1,3,4)P3 5/6-kinase
ITPK
ITPK1
ITPK2
ITPK3
additional information
additional information
the enzyme belongs to the ATP-grasp family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
determination of substrate binding sites, catalytic reaction mechanism
ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
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-
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ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
determination of substrate binding sites, catalytic reaction mechanism
ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Phosphorylation
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SYSTEMATIC NAME
IUBMB Comments
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase.
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CAS REGISTRY NUMBER
COMMENTARY
288307-53-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
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-
?
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
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-
?
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP
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enzyme catalyzes both forward and reverse reaction
putative regulator of Ca2+-activated chloride channels.
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r
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
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-
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r
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
enzyme displays isomerase activity
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-
?
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
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-
-
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r
1D-myo-inositol-1,3,4-trisphosphate + ATP
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ADP
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-
-
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r
1D-myo-inositol-1,4,5,6-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
AtITPK4 is more active against 1D-myo-inositol-1,4,5,6-tetrakisphosphate than against 1D-myo-inositol-3,4,5,6-tetrakisphosphate.
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-
?
1D-myo-inositol-1,4,6-trisphosphate + 1D-myo-inositol-3,4,6-trisphosphate + 2 ATP
2 1D-myo-inositol-1,3,4,6-tetrakisphosphate + 2 ADP
racemic mixture
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?
1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
enzyme displays isomerase activity
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-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol 1,4,6-trisphosphate + 1D-myo-inositol 3,4,6-trisphosphate
ADP + inositol tetrakisphosphate
racemic mix of phosphates
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-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ATP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
ADP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate
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-
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
?
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-
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
ATP + IkappaBalpha
ADP + phosphorylated IkappaBalpha
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substrate of the free enzyme and the COP9 signalosome complex
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-
?
ATP + p53
ADP + phosphorylated p53
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substrate of the free enzyme and the COP9 signalosome complex
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-
?
1D-myo-inositol-1,3,4-trisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP
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-
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?
1D-myo-inositol-1,3,4-trisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP
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r
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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-
-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
The substrate is converted to InsP4 but not to InsP5
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-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
-
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?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
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-
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?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
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-
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r
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
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recombinant enzyme, 3fold lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
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-
-
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
5fold lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
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-
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
-
-
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?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
5fold lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
substrate of the free enzyme and the COP9 signalosome complex
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
5fold lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
recombinant enzyme, 3fold higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
5fold higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
the formation of 1D-myo-inositol-1,3,4,6-tetrakisphosphate is slightly preferred compared to formation of 1D-myo-inositol-1,3,4,5-tetrakisphosphate, ratio 1.5:1
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
5fold higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
substrate of the free enzyme and the COP9 signalosome complex
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
5fold higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation
-
-
?
ATP + ATF-2
ADP + phosphorylated ATF-2
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phosphorylation predominantly on serine residues
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-
?
ATP + ATF-2
ADP + phosphorylated ATF-2
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phosphorylation predominantly on serine residues
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-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
-
substrate of the free enzyme and the COP9 signalosome complex, which both show no activity with the 1-79 residue fragment of c-Jun
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?
additional information
?
-
the enzyme is involved in photomorphogenesis under red light conditions
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-
?
additional information
?
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the enzyme performs autophosphorylation, the enzyme is associated with the COP9 signalosome, i.e. CSN
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?
additional information
?
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the enzyme displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity. It lacks the Ins(3,4,5,6)P4 1-kinase
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-
?
additional information
?
-
the enzyme displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity. It lacks the Ins(3,4,5,6)P4 1-kinase
-
-
?
additional information
?
-
the enzyme displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity. It lacks the Ins(3,4,5,6)P4 1-kinase
-
-
?
additional information
?
-
the enzyme displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity. It lacks the Ins(3,4,5,6)P4 1-kinase
-
-
?
additional information
?
-
-
the enzyme displays inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity. It lacks the Ins(3,4,5,6)P4 1-kinase
-
-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
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-
?
additional information
?
-
enzyme displays both kinase and phosphatase activity.
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-
?
additional information
?
-
enzyme displays both kinase and phosphatase activity.
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-
?
additional information
?
-
enzyme displays both kinase and phosphatase activity.
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-
?
additional information
?
-
enzyme displays both kinase and phosphatase activity.
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-
?
additional information
?
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-
enzyme displays both kinase and phosphatase activity.
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?
additional information
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the enzyme also performs the reaction of EC 2.7.1.134, phosphorylation of position 1 of 1D-myo-inositol 3,4,5,6-tetrakisphosphate
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?
additional information
?
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the enzyme also performs the reaction of EC 2.7.1.134, phosphorylation of position 1 of 1D-myo-inositol 3,4,5,6-tetrakisphosphate
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?
additional information
?
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the enzyme also performs the reaction of EC 2.7.1.134, phosphorylation of position 1 of 1D-myo-inositol 3,4,5,6-tetrakisphosphate
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?
additional information
?
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the enzyme is involved in both the inositol phosphate and the stress response pathways which are linked by the enzyme, overview
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?
additional information
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the enzyme is part of the COP9 signalosome complex consisting of 8 proteins
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?
additional information
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the enzyme also preferably performs the phosphoinositol trisphosphate 3-kinase reaction with 1D-myo-inositol-1,4,5-trisphosphate as substrate, EC 2.7.1.127, no activity with 1D-myo-inositol-1,4-bisphosphate
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?
additional information
?
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the enzyme shows multiple activities
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?
additional information
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the enzyme also preferably performs the phosphoinositol trisphosphate 3-kinase reaction with 1D-myo-inositol-1,4,5-trisphosphate as substrate, EC 2.7.1.127, no activity with 1D-myo-inositol-1,4-bisphosphate
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?
additional information
?
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ITPK can also interconvert Ins (3,4,5,6)P4 and Ins (1,3,4,5,6)P5 within a substrate cycle to regulate the concentration of Ins (3,4,5,6)P4
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additional information
?
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regulation of enzymes involved in the inositol phosphate metabolism in human cells, overview
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?
additional information
?
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the enzyme inhibits tumor necrosis factor alpha-induced apoptosis involving the activation of PARP, BID, caspase-3 and caspase-8, but protects not against etoposide- or cycloheximide-induced apotosis, mechanism
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?
additional information
?
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the enzyme associates with the COP9 signalosome, an complex of 8 proteins, by binding to CSN1
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?
additional information
?
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the enzyme is part of the COP9 signalosome complex consisting of 8 proteins
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?
additional information
?
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integration of inositol phosphate signaling pathways via human ITPK1
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?
additional information
?
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enzyme has both phosphatase and kinase activity
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?
additional information
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The enzyme can phosphorylate both 1D-myo-inositol-1,3,4-trisphosphate at the 5 or 6 positions and 1D-myo-inositol-3,4,5,6-tetrakisphosphate at the 1 position and can also dephosphorylate 1D-myo-inositol-1,3,4,5,6-pentaakisphosphate to 1D-myo-inositol-3,4,5,6-tetrakisphosphate
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?
additional information
?
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The phenomenon of intersubstrate transfer is only found in the human enzyme, which can use 1D-myo-inositol 1,3,4-trisphosphate to regulate increased cellular concentrations of 1D-myo-inositol-3,4,5,6-tetrakisphosphate
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?
additional information
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the various enzyme activities manifested by ITPK1 provide a molecular mechanism that allows the receptor-activated changes in phospholipase C activity and consequent increases in the concentration of 1D-myo-inositol 1,3,4-trisphosphate to regulate the abundance of 1D-myo-inositol-3,4,5,6-tetrakisphosphate
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
-
-
?
1D-myo-inositol 1,3,4-trisphosphate + ATP
1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP
A1KXK8
key enzyme in the inositol phosphate pathway and a negative regulator of osmotic stress signaling
-
-
?
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP
-
enzyme catalyzes both forward and reverse reaction
putative regulator of Ca2+-activated chloride channels.
-
r
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
-
-
-
-
r
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
enzyme displays isomerase activity
-
-
?
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP
-
-
-
-
r
1D-myo-inositol-1,3,4-trisphosphate + ATP
1D-myo-inositol-1,3,4,5-tetrakisphosphate + ADP
-
-
-
-
r
1D-myo-inositol-1,4,6-trisphosphate + 1D-myo-inositol-3,4,6-trisphosphate + 2 ATP
2 1D-myo-inositol-1,3,4,6-tetrakisphosphate + 2 ADP
racemic mixture
-
-
?
1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP
enzyme displays isomerase activity
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol 1,4,6-trisphosphate + 1D-myo-inositol 3,4,6-trisphosphate
ADP + inositol tetrakisphosphate
racemic mix of phosphates
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
1D-myo-inositol-1,3,4-trisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP
-
-
-
?
1D-myo-inositol-1,3,4-trisphosphate + ATP
1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP
-
-
-
-
r
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
The substrate is converted to InsP4 but not to InsP5
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-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 1,3,4-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol-1,3,4-trisphosphate
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
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-
?
additional information
?
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the enzyme is involved in photomorphogenesis under red light conditions
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?
additional information
?
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AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
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-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
-
-
AtITPK4 differs from other family members in that it not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity. It displays inositol 1,4,5,6-tetrakisphosphate and inositol-1,3,4,5-tetrakisphosphate isomerase activity. With inositol tetrakisphosphate substrates, ITPK4 displays an isomerase activity (in the absence of inositol pentakisphosphate product) interpreting as phosphatase and kinase activity. AtITPK4 shows isomerase activity against other substrates. Removal of the 1- or 3-phosphate of inositol-1,3,4,6-tetrakisphosphate and subsequent rephosphorylation at the same position generates inositol-1,3,4,6-tetrakisphosphate.
-
-
?
additional information
?
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enzyme displays both kinase and phosphatase activity.
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-
?
additional information
?
-
enzyme displays both kinase and phosphatase activity.
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-
?
additional information
?
-
enzyme displays both kinase and phosphatase activity.
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-
?
addition