EC Number   |
General Information |
Reference |
|---|
   2.7.1.105 | evolution |
Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) enzymes are bi-functional enzymes encoded by four different genes (pfkfb1, pfkfb2, pfkfb3, pfkfb4) in vertebrates, phylogenetic analysis of Pfkfb enzymes in vertebrates, overview |
729793 |
| 2.7.1.105 | malfunction |
Akt inactivation blocks PFKFB2 phosphorylation and fructose 2,6-bisphosphate production |
-, 730008 |
| 2.7.1.105 | malfunction |
enzyme knockdown inhibits clonogenic growth and enhances paclitaxel sensitivity in ovarian and breast cancer cell lines with wild type TP53 |
760902 |
| 2.7.1.105 | malfunction |
knockdown of PFKFB3/iPFK2 in N-43/5 neurons causes a decrease in rates of glycolysis, which is accompanied by increased AMPK phosphorylation, increased AgRP mRNA levels and decreased CART mRNA levels. Overexpression of PFKFB3/iPFK2 in N-43/5 neurons causes an increase in glycolysis, which is accompanied by decreased AMPK phosphorylation and decreased AgRP mRNA levels and increased CART mRNA levels |
-, 738904 |
| 2.7.1.105 | malfunction |
knockdown of PFKFB4 in prostate cancer cells increases p62 and reactive oxygen species, but surprisingly increases autophagic flux. Addition of the reactive oxygen species scavenger N-acetyl cysteine prevents p62 accumulation in PFKFB4-depleted cells. PFKFB4 depletion acts upstream of ATG7 consistent with increased oxidative stress that induces autophagy and p62 upregulation |
739205 |
| 2.7.1.105 | malfunction |
Mb transgenic mice have reduced fructose 2,6-bisphosphate levels, due to cardiac expression of a transgene for a mutant, kinase deficient form of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) which controls the level of fructose 2,6-bisphosphate. Mb hearts are markedly more sensitive to transverse aortic constriction-induced damage showing lower fractional shortening in Mb-TAC mice as well as larger left ventricular end diastolic and end systolic diameters. Cardiac hypertrophy and pulmonary congestion are more severe in Mb-transverse aortic constriction mice, Mb transgene exacerbates transverse aortic constriction-induced increases in cardiac hypertrophy and lung weight, detailed phenotype, overview |
739456 |
| 2.7.1.105 | malfunction |
mutations in the phosphatase but not in the kinase domain of PFK-2/FBPase-2 alter sexual development and lead to suppression of the respiratory deficient DELTAcox phenotype |
761189 |
| 2.7.1.105 | malfunction |
PFKFB3 enzymes are activated in human cancers |
698929 |
| 2.7.1.105 | malfunction |
PFKFB4 inhibition in H-460 cells reduces glycolytic flux to lactate and glutamate. PFKFB4 inhibition in H-460 cells increases apoptosis under normoxic and hypoxic conditions |
730530 |
| 2.7.1.105 | malfunction |
silencing of PFKFB4 results in increased levels of Fru-2,6-P2 in prostate cancer cells, knockdown of PFKFB4 blocks prostate cancer cell growth and remarkably induced regression of prostate tumor xenografts |
737973 |
