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Literature summary for 2.7.1.105 extracted from

  • Yang, H.; Shu, Z.; Jiang, Y.; Mao, W.; Pang, L.; Redwood, A.; Jeter-Jones, S.L.; Jennings, N.B.; Ornelas, A.; Zhou, J.; Rodriguez-Aguayo, C.; Bartholomeusz, G.; Iles, L.R.; Zacharias, N.M.; Millward, S.W.; Lopez-Berestein, G.; Le, X.F.; Ahmed, A.A.; Piwnica-Worms, H.; Sood, A.K.; Bast, R.C.; Lu, Z.
    6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase-2 regulates TP53-dependent paclitaxel sensitivity in ovarian and breast cancers (2019), Clin. Cancer Res., 25, 5702-5716 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.105

Application

Application Comment Organism
medicine enzyme inhibition can enhance the effect of paclitaxel-based primary chemotherapy upon ovarian and breast cancers retaining wild type TP53 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Homo sapiens
-
 ADP + beta-D-fructose 2,6-bisphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens O60825
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
BT-20 cell
-
 Homo sapiens
-
HEY-A8 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
OC-316 cell
-
 Homo sapiens
-
ovary cancer cell
-
 Homo sapiens
-
OVCA-8 cell
-
 Homo sapiens
-
SKOV3IP cell
-
 Homo sapiens
-
ZR-75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
 r

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PFKFB2 the bifunctional enzyme has 6-phosphofructo-2-kinase and fructose-2,6-biphosphatase activities Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown inhibits clonogenic growth and enhances paclitaxel sensitivity in ovarian and breast cancer cell lines with wild type TP53 Homo sapiens
physiological function 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-2 regulates TP53-dependent paclitaxel sensitivity in ovarian and breast cancers Homo sapiens