EC Number   |
General Information |
Reference |
|---|
   2.4.2.64 | evolution |
present classes of tRNA-guanine transglycosylase have arisen via divergent, not convergent, evolution |
759860 |
| 2.4.2.64 | malfunction |
QTRT1 deficiency in human breast cancer cells can change the functions of regulation genes, which are critical in cell proliferation, tight junction formation, and migration in human breast cancer cells. The relative abundance of bacteria in tumors induced from wild type cells is significantly higher than those of QTRT1 deficiency cells |
758996 |
| 2.4.2.64 | metabolism |
the enzyme is responsible for the formation of queuosine in the anticodon loop (position 34) of tRNAAsp, tRNAAsn, tRNAHis, and tRNATyr |
759465 |
| 2.4.2.64 | physiological function |
the QTRT1 gene and tRNA Q-modification alter cell proliferation, junctions, and microbiome in tumors and the intestine, thus playing a critical role in breast cancer development |
758996 |
