Literature summary for 2.4.2.64 extracted from

Zhang, J.; Lu, R.; Zhang, Y.; Matuszek, Z.; Zhang, W.; Xia, Y.; Pan, T.; Sun, J.
tRNA queuosine modification enzyme modulates the growth and microbiome recruitment to breast tumors (2020), Cancers (Basel), 12, 628 .

Search for more literature for 2.4.2.64

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BXR0 AND Q9H974	Q9BXR0: catalytic subunit 1 (QTRT1), Q9H974: accessory subunit 2 (QTRT2)	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
QTRT1	gene name, catalytic subunit 1	Homo sapiens
QTRT2	gene name, accessory subunit 2	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	QTRT1 deficiency in human breast cancer cells can change the functions of regulation genes, which are critical in cell proliferation, tight junction formation, and migration in human breast cancer cells. The relative abundance of bacteria in tumors induced from wild type cells is significantly higher than those of QTRT1 deficiency cells	Homo sapiens
physiological function	the QTRT1 gene and tRNA Q-modification alter cell proliferation, junctions, and microbiome in tumors and the intestine, thus playing a critical role in breast cancer development	Homo sapiens

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Release 2023.1 (January 2023)