EC Number   |
General Information |
Reference |
|---|
    2.4.1.17 | evolution |
feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution |
735649 |
| 2.4.1.17 | evolution |
IPUT1 belongs to a glycosyltransferase family that transfers sugars with a retaining mechanism resulting in alpha-linked sugars, consistent with the alpha conformation of the GlcA in glycosyl inositol phosphorylceramides (GIPCs) |
759930 |
| 2.4.1.17 | evolution |
phylogenetic analysis of dog and human UGT1As |
736010 |
| 2.4.1.17 | evolution |
phylogenetic analysis of the dog and human UGT1As |
736010 |
| 2.4.1.17 | evolution |
UGT enzymes are genetically polymorphic |
735425 |
| 2.4.1.17 | evolution |
UGT3A enzymes are functionally distinct from other UGT subfamilies (which use UDP-glucuronic acid as a cosubstrate) due to their utilization of alternative cosubstrates (UDP-N-acetylglucosamine for UGT3A1, and UDP-glucose and UDP-xylose for UGT3A2). The overall expression level in tissue is higher for isozyme UGT3A2 compared to isozyme UGT3A1 |
759116 |
| 2.4.1.17 | evolution |
UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview |
735776 |
| 2.4.1.17 | malfunction |
due to frequent haplotype blocks within the UGT1 gene locus, the Gilbert variant UGT1A1*28 is often associated with polymorphisms of UGT1A6. Rare hyperserotoninemia mimicking carcinoid syndrome may be due to the linked dual polymorphisms of UGT1A1 and UGT1A6 |
735649 |
| 2.4.1.17 | malfunction |
knockdown of isoforms UGT330A3, UGT344D5, UGT348A3, and UGT349A3 significantly increases Myzus persicae nicotianae sensitivity to nicotine |
756996 |
| 2.4.1.17 | malfunction |
life saving function of bilirubin glucuronidation is obvious from death of children carrying the UGT1A1-deficient Crigler-Najjar syndrome, type 1 genotype. Excessive serum bilirubin levels leading to brain damage in neonates are prevented by induction of UGT1A1, the sole enzyme conjugating bilirubin. Reduced L-thyroxine (T4)glucuronidation in carriers of the Gilbert genotype UGT1A1*28 substantiates a role for UGT1A1 in T4 glucuronidation. Due to frequent haplotype blocks within the UGT1 gene locus, the Gilbert variant UGT1A1*28 is often associated with polymorphisms of UGT1A6. Rare hyperserotoninemia mimicking carcinoid syndrome may be due to the linked dual polymorphisms of UGT1A1 and UGT1A6 |
735649 |
