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(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
-
substrate for isoforms UGT1A9 and UGT1A10
-
-
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
-
substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
-
-
?
(-)-borneol + UDP-glucuronate
UDP + (-)-borneol-O-alpha-D-glucuronide
-
-
-
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
-
-
-
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
-
-
-
-
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
-
-
-
-
?
(R)-propanolol + UDP-glucuronate
UDP + (R)-propanolol O-glucuronide
-
-
-
-
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
beta-D-glucuronosyl (S)-naproxen + UDP
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
UDP + beta-D-glucuronosyl (S)-naproxen
-
-
-
-
?
(S)-propanolol + UDP-glucuronate
UDP + (S)-propanolol O-glucuronide
-
-
-
-
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
-
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
1-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-beta-D-glucuronide
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
?
-
-
-
?
1-hydroxy[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
-
-
-
-
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl O-glucuronide + UDP
-
-
-
-
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl-O-glucuronide + UDP
-
-
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl 1-O-glucuronate + UDP
-
-
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl-O-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
?
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
10-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-10-yl-beta-D-glucuronide
-
-
-
?
11-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-11-yl-beta-D-glucuronide
-
-
-
?
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-alpha-D-glucuronate
-
-
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
-
-
-
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-alpha-D-glucuronate
UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprogesteron-16-O-alpha-D-glucuronate
-
-
-
?
17-epiestriol + UDP-glucuronate
?
-
-
-
-
?
17-epiestriol + UDP-glucuronate
UDP + ?
-
-
-
-
?
17alpha-estradiol + UDP-alpha-D-glucuronate
? + UDP
-
-
-
-
?
17alpha-ethynylestradiol + UDP-glucuronate
UDP + 17alpha-ethynylestradiol 3-O-beta-D-glucuronide
-
-
-
?
17beta-estradiol + UDP-alpha-D-glucuronate
? + UDP
-
-
-
-
?
17beta-estradiol + UDP-glucuronate
?
17beta-ethynylestradiol + UDPglucuronate
?
-
-
-
?
17beta-hydroxy-5alpha-androstan-3-one + UDPglucuronate
UDP + 17beta-hydroxy-5alpha-androstan-3-one 17O-glucuronide
-
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
2',4,4'-trihydroxychalcone + UDP-glucuronate
UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
-
i.e. isoliquiritigenin
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
-
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
-
-
?
2-aminobenzoate + UDPglucuronate
UDP + ?
-
-
-
-
?
2-aminobiphenyl + UDP-glucuronate
?
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
2-hydroxy-2',3',4',5'-tetrachlorobiphenyl + UDPglucuronate
UDP + 2',3',4',5'-tetrachlorobiphenyl 2-O-glucuronate
-
-
-
?
2-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-2-yl-beta-D-glucuronide
-
-
-
?
2-hydroxyestradiol + UDP-glucuronate
?
-
-
-
-
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
2-hydroxyestrone + UDP-glucuronate
?
-
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-alpha-D-glucuronate
-
-
-
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
substrate of isoform UGT2B7
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
3,5-dinitrocatechol + UDP-glucuronate
?
-
-
-
?
3-azido-4-chlorobenzoic acid + UDP-glucuronate
?
-
-
-
?
3-azidobenzoic acid + UDP-glucuronate
?
-
-
-
?
3-hydroxy-benzo(a)pyrene + UDP-glucuronate
3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
-
-
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
3-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-3-yl-beta-D-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
4-aminobiphenyl + UDP-glucuronate
UDP + 4-aminobiphenyl N-glucuronide
-
-
-
-
?
4-aminobiphenyl + UDPglucuronate
UDP + ?
-
catalyzed by isozyme 1 but not by isozyme 2
-
-
?
4-azido-2-hydroxybenzoic acid + UDPglucuronate
?
-
-
-
?
4-azidobenzoic acid + UDP-glucuronate
?
-
-
-
?
4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl + UDPglucuronate
UDP + 2,3,3',4',5'-pentachlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',3,3',4',5,5'-heptachlorobiphenyl + UDPglucuronate
UDP + 2',3,3',4',5,5'-hexachlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl + UDPglucuronate
UDP + 2',3,4',5,6'-pentachlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',3,4',6'-tetrachlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',4',6'-trichlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-4-yl-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
4-hydroxybiphenyl + UDPglucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
4-hydroxyestradiol + UDP-glucuronate
?
-
-
-
-
?
4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
4-hydroxyestrone + UDP-glucuronate
?
-
-
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
-
-
-
-
?
4-methylumbeliferone + UDP-alpha-D-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
-
-
-
-
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
4-n-octylgallate + UDPglucuronate
UDP + 4-n-octylgallate 3-O-glucuronide
-
highly specific for UGT1A71
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate
5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP
-
i.e. antitumor agent C-1311, NSC-645809
-
-
?
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP
-
i.e. antitumor agent C-1305
-
-
?
5-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-5-yl-beta-D-glucuronide
-
-
-
?
5-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 5-hydroxybenzo[a]pyrene O-glucuronide
-
glucuronidated by UGT1A3
-
?
5-methylchrysene-1,2-diol + UDP-glucuronate
? + UDP
-
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
?
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
5beta-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5beta-androstane-3alpha,17beta-diol O-glucuronide
-
-
-
?
6-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-6-yl-beta-D-glucuronide
-
-
-
?
6-hydroxywarfarin + UDP-glucuronate
? + UDP
-
-
-
-
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
7-hydroxy-4-(trifluoromethyl)-coumarin + UDPglucuronate
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
-
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
7-hydroxy-benzo(a)pyrene + UDP-glucuronate
7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP
-
-
-
-
?
7-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-7-yl-beta-D-glucuronide
-
-
-
?
7-hydroxycoumarin + UDP-glucuronate
UDP + coumarin-7-yl-alpha-D-glucuronide
-
-
-
?
7-hydroxywarfarin + UDP-glucuronate
? + UDP
-
-
-
-
?
8-hydroxy-benzo(a)pyrene + UDP-glucuronate
8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP
-
-
-
-
?
8-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-8-yl-beta-D-glucuronide
-
-
-
?
8-hydroxyquinoline + UDPglucuronate
UDP + 8-hydroxyquinoline 8-O-glucuronide
-
-
-
?
8-hydroxywarfarin + UDP-glucuronate
? + UDP
-
-
-
-
?
9-hydroxybenzo(a)pyrene + UDP-glucuronate
?
9-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-9-yl-beta-D-glucuronide
-
-
-
?
acetaminophen + UDP-glucuronate
?
alpha-naphthylamine + UDPglucuronate
UDP + ?
alprazolam + UDP-alpha-D-glucuronate
alprazolam D-glucuronate + UDP
-
-
-
-
?
amitriptyline + UDP-glucuronate
?
-
-
-
-
?
androstane-3alpha,17beta diol + UDPglucuronate
UDP + androstane-3alpha,17beta diol O-glucuronide
-
-
-
?
androsterone + UDP-glucuronate
?
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
anthraflavic acid + UDPglucuronate
UDP + ?
apigenin + UDPglucuronate
UDP + apigenin O-glucuronide
benzo(a)pyrene-7,8-diol + UDP-glucuronate
? + UDP
-
-
-
-
?
benzo[a]pyrene 3,6-diphenol + UDP-glucuronate
?
-
converted readily to mono- and diglucuronides
-
-
?
benzo[a]pyrene 3,6-quinone + UDPglucuronate
benzo[a]pyrene 3,6-quinol glucuronide + UDP
-
-
no information to which positions 3-, 6-, or both the glucuronate is attached
?
benzo[a]pyrene-3,6-quinol + UDPglucuronate
benzo[a]pyrene 3,6-quinol mono- and diglucuronide + UDP
-
-
-
?
benzo[a]pyrene-7,8(+)-diol + UDP-glucuronate
?
-
-
-
?
benzo[a]pyrene-7,8(-)diol + UDP-glucuronate
?
-
-
-
?
beta-estradiol + UDP-alpha-D-glucuronate
beta-estradiol-3-glucuronide + UDP
-
-
-
-
?
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
bifonazole + UDP-alpha-D-glucuronate
bifonazole D-glucuronate + UDP
-
-
-
-
?
bilirubin + UDP-glucuronate
?
-
-
-
?
bilirubin + UDP-glucuronate
bilirubin D-glucuronate + UDP
-
-
-
-
?
bilirubin + UDP-glucuronate
bilirubin glucuronoside + UDP
-
UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
bisphenol A + UDP-glucuronate
?
-
-
-
?
borneol + UDPglucuronate
UDP + borneol O-glucuronide
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
cannabinol + UDP-glucuronate
? + UDP
-
substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10
-
-
?
carvacrol + UDP-glucuronate
caervcrol O-glucuronate + UDP
-
isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
chenodeoxycholic acid + UDPgalacturonate
UDP + chenodeoxycholic acid O-galacturonide
-
-
-
?
chloramphenicol + UDPglucuronate
UDP + chloramphenicol O-glucuronide
cholic acid + UDPglucuronate
cholic acid O-glucuronide
-
-
-
?
chrysin + UDP-glucuronate
?
-
-
-
?
clofibrate + UDPglucuronate
UDP + ?
codeine + UDPglucuronate
codeine-6-glucuronide + UDP
-
glucuronidated by HGT2B7H and HGT2B7Y
-
-
deferiprone + UDP-glucuronate
deferiprone 3-O-glucuronide + UDP
-
-
-
-
?
deoxycholic acid + UDPglucuronate
UDP + deoxycholic acid O-glucuronide
-
-
-
?
dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate
? + UDP
-
-
-
-
?
diclofenac + UDP-alpha-D-glucuronate
diclofenac D-glucuronide + UDP
-
-
-
-
?
diclofenac + UDPalpha-D-glucuronate
UDP + ?
digitoxigenin + UDPglucuronate
UDP + digitoxigenin O-glucuronide
-
-
-
?
dihydromorphine + UDPglucuronate
UDP + dihydromorphine O-glucuronide
-
-
-
?
dihydromorphone + UDPglucuronate
UDP + dihydromorphone O-glucuronide
-
-
-
?
dihydrotestosterone + UDP-alpha-D-glucuronate
dihydrotestosterone D-glucuronate + UDP
-
-
-
-
?
dihydrotestosterone + UDPglucuronate
UDP + dihydrotestosterone O-glucuronide
-
-
-
?
econazole + UDP-alpha-D-glucuronate
econazole D-glucuronate + UDP
-
-
-
-
?
edaravone + UDP-alpha-D-glucuronate
edaravone beta-D-glucuronate + UDP
-
i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7
-
-
?
epicatechin + UDP-glucuronate
?
-
-
-
?
epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
epitestosterone + UDP-glucuronate
UDP + epitestosterone O-glucuronide
-
glucuronidated by HGT2B7H and HGT2B7Y
-
?
estradiol + UDP-alpha-D-glucuronate
estradiol 3-O-glucuronate + UDP
sigmoidal kinetics with n of 1.7
-
-
?
estradiol + UDP-alpha-D-glucuronate
UDP + estradiol 3-O-glucuronide
-
substrate of isoform UGT1A1
-
-
?
estradiol + UDP-glucuronate
?
estradiol + UDP-glucuronate
estradiol 3-O-glucuronate + UDP
sigmoidal kinetics with n of 1.7
-
-
?
estradiol + UDPglucuronate
UDP + estradiol O-glucuronide
-
-
-
?
estradiol-17alpha + UDPglucuronate
UDP + 17-alpha-estradiol O-glucuronide
-
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
estriol + UDP-glucuronate
?
estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
estrogen + UDP-glucuronate
?
estrone + UDP-glucuronate
?
-
-
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
ethinylestradiol + UDPglucuronate
UDP + ethinylestradiol-3-glucuronide
-
-
-
?
etiocholanone + UDPglucuronate
UDP + etiocholanone O-glucuronide
etoposide + UDP-glucuronate
?
-
-
-
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
eugenol + UDP-glucuronate
?
-
-
-
-
?
eugenol + UDP-glucuronate
UDP + eugenol-O-alpha-D-glucuronide
-
-
-
-
?
fluconazole + UDP-alpha-D-glucuronate
fluconazole D-glucuronate + UDP
-
-
-
-
?
flurbiprofen + UDP-glucuronate
?
-
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
frusemide + UDP-alpha-D-glucuronate
frusemide D-glucuronide
-
-
-
-
?
glycolithocholic acid + UDPglucuronate
UDP + glycolithocholic acid O-glucuronide
-
lowest activity among five bile acids studied
-
?
hyodeoxycholic acid + UDP-glucuronate
?
hyodeoxycholic acid + UDPglucuronate
UDP + hyodeoxycholic acid O-glucuronide
ibuprofen + UDPglucuronate
UDP + ?
imipramine + UDPglucuronate
UDP + ?
itraconazole + UDP-alpha-D-glucuronate
?
-
-
-
-
?
ketoconazole + UDP-alpha-D-glucuronate
?
-
-
-
-
?
lamotrigine + UDP-alpha-D-glucuronate
lamotrigine D-glucuronate + UDP
-
-
-
-
?
lamotrigine + UDP-glucuronate
UDP + ?
-
-
-
-
?
lithocholic acid + UDPglucuronate
UDP + ?
lorazepam + UDP-glucuronate
?
-
-
-
-
?
miconazole + UDP-alpha-D-glucuronate
miconazole D-glucuronate + UDP
-
-
-
-
?
midazolam + UDP-alpha-D-glucuronate
midazolam D-glucuronide + UDP
-
-
-
-
?
milnacipran + UDP-glucuronate
?
-
-
-
-
?
morphine + UDP-glucuronate
?
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
morphine + UDP-glucuronate
UDP + morphine 3-glucuronide + morphine 6-glucuronide
-
-
-
-
?
mycophenolate + UDP-glucuronate
?
-
-
-
-
?
mycophenolic acid + UDP-alpha-D-glucuronate
mycophenolic acid D-glucuronide
-
-
-
-
?
N-hydroxy-2-acetylaminofluorene + UDPglucuronate
UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide
-
glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives
-
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
nalorphine + UDPglucuronate
UDP + nalorphine O-glucuronate
-
-
-
?
naloxone + UDPglucuronate
UDP + naloxone O-glucuronide
-
-
-
?
naltrexone + UDPglucuronate
UDP + naltrexone O-glucuronide
-
-
-
?
octylgallate + UDPglucuronate
?
-
-
-
?
olanzapine + UDP-glucuronate
?
-
-
-
-
?
opiates + UDPglucuronate
opiates 6-O-glucuronides + UDP
-
substrate for UGT2B7
-
-
oxazepam + UDP-glucuronate
?
-
-
-
-
?
oxymorphone + UDPglucuronate
UDP + oxymorphone O-glucuronide
-
-
-
?
p-ethoxyphenylurea + UDP-glucuronate
?
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
planar phenols + UDPglucuronate
UDP + phenylglucuronides
-
expressed before birth
-
-
-
profen + UDPglucuronate
UDP + ?
propofol + UDP-alpha-D-glucuronate
propofol D-glucuronide
-
-
-
-
?
propofol + UDP-alpha-D-glucuronate
UDP + estradiol O-glucuronide
-
substrate of isoform UGT1A9
-
-
?
propofol + UDP-glucuronate
UDP + propofyl beta-D-glucuronide
-
-
-
?
quercetin + UDPglucuronate
UDP + quercetin O-glucuronide
retigabine + UDP-alpha-D-glucuronate
retigabine D-glucuronide
-
-
-
-
?
retigabine + UDP-glucuronate
UDP + retigabine N-glucuronide
-
-
-
-
?
scopoletin + UDP-glucuronate
?
-
-
-
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucoside
very low rate of glucuronidation
-
-
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
-
-
-
-
?
scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
senecionine + UDP-alpha-D-glucuronate
senecionine N-glucuronide + UDP
-
senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics
-
-
?
serotonin + UDP-glucuronate
?
-
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
sulconazole + UDP-alpha-D-glucuronate
sulconazole D-glucuronate + UDP
-
-
-
-
?
sulfinpyrazone + UDP-alpha-D-glucuronate
sulfinpyrazone D-glucuronide
-
-
-
-
?
tamoxifen + UDP-alpha-D-glucuronate
tamoxifen-N-glucuronate + UDP
-
-
-
-
-
tamoxifen + UDP-glucuronate
UDP + ?
-
-
-
-
?
testosterone + UDP-glucuronate
?
testosterone + UDP-glucuronate
UDP + testosterone 17-O-glucuronide
-
isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone-17-O-alpha-D-glucuronate
-
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone-17alpha-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
thiophenol + UDPglucuronate
thiophenyl thio-beta-D-glucuronide + UDP
tioconazole + UDP-alpha-D-glucuronate
tioconazole D-glucuronate + UDP
-
-
-
-
?
tranilast + UDP-glucuronate
tranilast glucuronoside + UDP
-
-
-
-
?
trans-4-hydroxytamoxifen + UDP-glucuronate
UDP + ?
-
-
-
-
?
trans-androsterone + UDP-alpha-D-glucuronate
trans-androsterone D-glucuronate + UDP
-
-
-
-
?
trans-endoxifen + UDP-glucuronate
UDP + ?
-
-
-
-
?
trifluoperazine + UDP-glucuronate
UDP + ?
-
substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P
-
-
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
isozyme UGT1A1
-
-
?
UDP-alpha-D-glucuronate + biphenyl-4,4'-diol
UDP + 4'-hydroxybiphenyl-4-yl beta-D-glucopyranosiduronate
-
-
-
-
?
UDP-alpha-D-glucuronate + diclofenac
UDP + diclofenac O-beta-D-glucuronide
-
-
-
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid
-
substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
-
-
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid
-
-
substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
-
?
UDP-alpha-D-glucuronate + sorafenib
UDP + ?
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-alpha-glucuronate + diclofenac
UDP + beta-D-glucuronosyl-diclofenac
-
-
-
-
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
UDP-D-glucuronate + 11alpha-hydroxyprogesterone
UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside
an UGT2B7 substrate
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3
UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside
among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview
-
-
?
UDP-D-glucuronate + 2-hydroxyestradiol
UDP + 2-hydroxyestradiol beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 2-naphthol
UDP + 2-naphthyl beta-D-glucuronoside
UDP-D-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside
model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview
-
-
?
UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
-
specific substrate of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone
UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-hydroxy-estrone
UDP + ?
-
-
-
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferonyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-O-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-O-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol
UDP + ?
-
-
-
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
UDP-D-glucuronate + acacetin
UDP + acacetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
UDP-D-glucuronate + anthraflavic acid
UDP + ?
-
-
-
-
?
UDP-D-glucuronate + apigenin
UDP + apigenin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + beta-D-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + bilirubin
UDP + ?
-
-
-
-
?
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
-
-
-
-
?
UDP-D-glucuronate + candesartan
UDP + candesartan beta-D-glucuronoside
-
isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide
-
-
?
UDP-D-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
UDP-D-glucuronate + cotinine
UDP + ?
UDP-D-glucuronate + curcumin
UDP + curcumin beta-D-glucuronoside
-
low activity, can reverse the inhibtory effect of curcumin on UGTs
-
-
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
-
-
-
-
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
UDP-D-glucuronate + eriodictyol
UDP + eriodictyol 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
UDP-D-glucuronate + estriol
UDP + ?
-
-
-
-
?
UDP-D-glucuronate + estriol
UDP + estriol 3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + estriol
UDP + estriol glucuronoside
-
-
-
-
?
UDP-D-glucuronate + eugenol
UDP + eugenol beta-D-glucuronoside
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
-
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
UDP-D-glucuronate + hesperetin
UDP + hesperetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + homoeriodictyol
UDP + homoeriodictyol 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24-carboxy-glucuronoside
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 3-O-glucuronoside
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
UDP-D-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
-
reaction of isozyme UGT1A4
-
-
?
UDP-D-glucuronate + isolongifolol
UDP + isolongifolol beta-D-glucuronoside
-
the compound is substrate and competitive inhibitor
-
-
?
UDP-D-glucuronate + kaempferol
UDP + kaempferol 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + labetalol
UDP + ?
UDP-D-glucuronate + longifolol
UDP + longifolol beta-D-glucuronoside
-
the compound is substrate and competitive inhibitor
-
-
?
UDP-D-glucuronate + losartan
UDP + losartan beta-D-glucuronoside
-
no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring
-
-
?
UDP-D-glucuronate + luteolin
UDP + luteolin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 1-O-beta-D-glucuronoside
-
-
isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1
-
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 4-O-beta-D-glucuronoside
-
-
isoform UGT1A10, preferential formation of 4-menadiol glucuronoside, isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
-
activity of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
UDP-D-glucuronate + morphine
UDP + morphine 6-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + mycophenolate
UDP + ?
UDP-D-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
-
K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview
-
-
?
UDP-D-glucuronate + myricetin
UDP + myricetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + naringenin
UDP + naringenin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + nicotine
UDP + ?
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-glucuronoside
an UGT2B15 substrate
-
-
?
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-monoglucuronoside
-
-
-
-
?
UDP-D-glucuronate + phloretin
UDP + ?
-
-
-
-
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
UDP-D-glucuronate + quercetin
UDP + quercetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
isozyme UGT1A6
-
-
?
UDP-D-glucuronate + serotonin
UDP + serotonin O-beta-D-glucuronoside
-
reaction of isozyme UGT1A6
-
-
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
UDP-D-glucuronate + testosterone
UDP + testosterone 17-O-beta-D-glucuronoside
an UGT2B15 substrate
-
-
?
UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
UDP-D-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + umbelliferone
UDP + umbelliferyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
UDP-D-glucuronate + zolarsartan
UDP + zolarsartan beta-D-glucuronoside
-
isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7
-
-
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
UDP + ?
-
i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9
-
-
?
UDP-glucuronate + (S)-oxazepam
UDP + (S)-oxazepam beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 1,25-dihydroxyergocalciferol
UDP + 1,25-dihydroxyergocalciferol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 1-hydroxypyrene
UDP + 1-hydroxypyrene beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 4'-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 5-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 10-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl-beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl-beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
UDP-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-glucuronide
-
-
-
?
UDP-glucuronate + 17beta-estradiol
UDP + estradiol 17-beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 2'-hydroxychalcone 4'-O-beta-D-glucuronoside
-
glucuronidation at the OH-4' position by UGT1A1 and UGT1A10 isoforms, both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
-
-
?
UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 4'-hydroxychalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position with low activity by UGT1A7, UGT1A6, and UGT1A10 isoforms, and with high activity by isozyme UGT1A9. Both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
-
-
?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
?
UDP-glucuronate + 2'-hydroxychalcone
UDP + chalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position by UGT1A9 isoform
-
-
?
UDP-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 2-methoxyestrone
UDP + 2-methoxyestrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 20-hydroxyeicosatetraenoic acid
UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 25-hydroxyergocalciferol
UDP + 25-hydroxyergocalciferol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide
-
isozymes UGT2B4, UGT2B7, and UGT2B17
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
UDP-glucuronate + 3,17-estradiol
UDP + 17-estradiol 3-O-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + 3,17-estradiol
UDP + 3-estradiol 17-O-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + 3,2'-dihydroxychalcone
UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone
UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide
high activity
-
-
?
UDP-glucuronate + 4,2'-dihydroxychalcone
UDP + 4-hydroxychalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position by UGT1A8, UGT1A1, and UGT1A3 isoforms. The A-ring OH-4 group promotes glucuronidation at the 2' position for the reaction of the exclusive substrate 4,2'-dihydroxychalcone of UGT1A1 and 1A3
-
-
?
UDP-glucuronate + 4-aminobiphenyl
?
-
-
-
-
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
-
-
?
UDP-glucuronate + 4-hydroxyestradiol
UDP + 4-hydroxyestradiol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 4-hydroxyretinoic acid
UDP + 4-hydroxyretinoic acid beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 mainly conjugated by UGT2B7
-
-
?
UDP-glucuronate + 4-methoxyestrone
UDP + 4-methoxyestrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronide
-
all isozymes, nonselective substrate
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenol beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronide
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxy-tryptophol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronide
isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity
-
-
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6
-
-
?
UDP-glucuronate + 5alpha-dihydroaldosterone
UDP + 5alpha-dihydroaldosterone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 5alpha-tetrahydrocortisone
UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 5beta-tetrahydrocortisone
UDP + 5beta-tetrahydrocortisone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 4'-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 6-hydroxymelatonin
UDP + 6-hydroxymelatonin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxy-camptothecin
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 i.e. SN-38, an active metabolite of irinotecan
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxycampothecin
UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide
i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
i.e. SN-38, an active metabolite of irinotecan
-
-
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 7-hydroxyflavanone
UDP + flavanone 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 4'-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 5-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 8-hydroxyquinoline
UDP + 8-hydroxyquinoline beta-D-glucuronide
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
UDP-glucuronate + aldosterone
UDP + aldosterone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + all-trans-retinoic acid
UDP + all-trans-retinoic acid beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 mainly conjugated by UGT2B7
-
-
?
UDP-glucuronate + Aloe-emodin
UDP + Aloe-emodin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + alpinetin
UDP + alpinetin beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + amitriptyline
UDP + amitriptyline beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + amitryptiline
UDP + amitryptiline beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
-
isozyme UGT2B15
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
UDP-glucuronate + androstanediol
UDP + androstanediol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
UDP-glucuronate + asialo-orosomucoid
UDP + asialo-orosomucoid beta-D-glucuronide
-
acceptor is a glycoprotein, preferred substrate
-
-
?
UDP-glucuronate + beta-estradiol
UDP + estradiol 3-beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + bilirubin
?
-
-
-
-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
UDP-glucuronate + buprenorphine
UDP + buprenorphine glucuronide
UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
UDP-glucuronate + cardamonin
UDP + cardamonin beta-D-glucuronoside
-
UGT1A9 is the only isoform to glucuronidate cardamonin at the OH-2' position, lower activity with isozyme UGT1A7
-
-
?
UDP-glucuronate + carvedilol
UDP + carvedilol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
UDP-glucuronate + chloramphenicol
UDP + ?
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + cholic acid
UDP + cholic acid 24-beta-D-glucuronoside
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
UDP-glucuronate + citronellol
UDP + citronellol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + clozapine
UDP + clozapine beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + codeine
UDP + beta-D-glucuronosyl-codeine
-
low activity
-
-
?
UDP-glucuronate + codeine
UDP + codeine beta-D-glucuronide
-
isozymes UGT2B4 and UGT2B7
-
-
?
UDP-glucuronate + cotinine
UDP + cotinine N-beta-D-glucuronoside
cotinine is a highly selective substrate of human liver microsomal UGT2B10
-
-
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
UDP-glucuronate + cyproheptadine
UDP + cyproheptadine beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + deferiprone
UDP + deferiprone beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
UDP-glucuronate + deoxycholic acid
UDP + deoxycholic acid 24-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + desmethylnaproxen
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
UDP-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + diphenhydramine
UDP + diphenhydramine beta-D-glucuronoside
UDP-glucuronate + dopamine
UDP + dopamine beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronide
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
UDP-glucuronate + epirubicin
UDP + epirubicin beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronoside
UDP-glucuronate + estriol
UDP + estriol beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronide
isozyme UGT1A1 is specific for etoposide
-
-
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
UDP-glucuronate + eugenol
UDP + eugenol beta-D-glucuronide
UDP-glucuronate + flavopiridol
UDP + flavopiridol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + flufenamic acid
?
-
-
-
?
UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + gingerol
UDP + gingerol 4'-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
UDP-glucuronate + hydromorphone
UDP + beta-D-glucuronosyl-hydromorphone
-
-
-
-
?
UDP-glucuronate + hyocholic acid
UDP + hyocholic acid 24-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + beta-D-glucuronosyl-hyodeoxycholic acid
-
high activity
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24G-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholoyl beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + ibuprofen
UDP + beta-D-glucuronosyl-ibuprofen
-
-
-
-
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronoside
UDP-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
UDP-glucuronate + ketoconazole
UDP + ketoconazole beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
UDP-glucuronate + ketotifen
UDP + ketotifen beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + ketotifen
UDP + ketotifenbeta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + L-thyroxine
UDP + L-thyroxyl beta-D-glucuronoside
UDP-glucuronate + lamotrigine
UDP + lamotrigine beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + leukotriene B4
UDP + leukotriene B4 beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
UDP-glucuronate + levomedetomidine
UDP + levomedetomidine beta-D-glucuronoside
UDP-glucuronate + lithocholic acid
UDP + lithocholic acid 3-beta-D-glucuronoside + lithocholic acid 24-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + lorazepam
UDP + beta-D-glucuronosyl-lorazepam
-
-
-
?
UDP-glucuronate + lorazepam
UDP + lorazepam beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + mefenamic acid
?
-
-
-
?
UDP-glucuronate + midazolam
UDP + midazolam beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
UDP-glucuronate + morphine 3-glucuronide
UDP + ?
-
-
-
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
UDP-glucuronate + mycophenolic acid
UDP + mycophenoloyl beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + N-acetylserotonin
UDP + N-acetylserotonin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + naphthol
UDP + naphthol glucuronide
-
isozyme UGT1A6
-
-
?
UDP-glucuronate + naproxen
?
UDP-glucuronate + naproxen
UDP + naproxen beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
UDP-glucuronate + niflumic acid
?
-
-
-
?
UDP-glucuronate + olanzapine
UDP + olanzapine beta-D-glucuronoside
UDP-glucuronate + p-nitrophenol
UDP + 4-nitrophenyl-alpha-D-glucuronide
-
-
-
-
?
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronide
-
-
-
?
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + paragloboside
UDP + paragloboside beta-D-glucuronide
-
acceptor is a glycolipid, activity requires phosphatidylinositol
-
-
?
UDP-glucuronate + phenylbutazone
?
among 16 UDP-glucuronosyltransferase isoforms investigated, only UGT1A9 catalyzes PB C-glucuronidation
-
-
?
UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
UDP-glucuronate + pizotifen
UDP + pizotifen beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + pregnan-3,17-diol
UDP + pregnan-3,17-diol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + propofol
UDP + propofol alpha-D-glucuronide
-
isozyme UGT1A9
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
UDP-glucuronate + quinizarin
UDP + quinizarin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + serotonin
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronide
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
isozyme UGT2B7
-
-
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
UDP-glucuronate + tacrolimus
UDP + tacrolimus beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen beta-D-glucuronoside
UDP-glucuronate + tamoxifen
UDP + tamoxifen N-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + Telmisartan
UDP + Telmisartan beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronide
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + tigogenin
UDP + tigogenin beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + tolcapone
UDP + tolcapone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + trans-androsterone
UDP + trans-androsterone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + trans-resveratrol
UDP + trans-resveratrol beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronide
isozyme UGT1A4
-
-
?
UDP-glucuronate + trifluoroperazine
UDP + trifluoroperazine beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + trifluperazine
UDP + trifluperazine
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + umbelliferone
UDP + umbelliferone beta-D-glucuronide
UDP-glucuronate + valproic acid
UDP + beta-D-glucuronosyl-valproic acid
-
-
-
-
?
UDP-glucuronate + vorinostat
UDP + vorinostat beta-D-glucuronoside
O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1 -
-
-
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
UDP-glucuronate + zidovudine
UDP + zidovudine O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronic acid + 7-hydroxy-4-(trifluoromethyl)-coumarin
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
-
UGT1A6, UGT1A9, and UGT2B7
-
-
?
UDP-glucuronic acid + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronide
-
UGT1A3
-
-
?
UDP-glucuronic acid + bilirubin
bilirubin glucuronoside + UDP
Q20CK6, Q20CK7, Q20CK8, Q20CK9, Q20CL0, Q20CL1, Q20CL2, Q20CL3, Q20CL4, Q20CL5, Q20CL6 -
-
-
?
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
UDP-glucuronic acid + diclofenac
UDP + diclofenac O-glucuronide
-
-
-
-
?
UDP-glucuronic acid + imipramine
UDP + imipramine N-glucuronide
-
-
-
-
?
UDP-glucuronic acid + serotonin
UDP + serotonin O-glucuronide
-
-
-
-
?
UDP-glucuronic acid + trifluoperazine
UDP + ?
-
UGT1A4
-
-
?
UDP-glucuronic acid + trifluoperazine
UDP + trifluoperazine N-glucuronide
-
-
-
-
?
UDPglucuronate + bilirubin
?
-
-
-
-
?
UDPglucuronate + naproxen
?
-
UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
-
-
?
ursodeoxycholic acid + UDPglucuronate
UDP + ursodeoxycholic acid O-glucuronide
valproic acid + UDPglucuronate
UDP + ?
vanillin + UDP-glucuronate
UDP + vanillin O-glucuronide
-
other 7 phenolic compounds show substrate activity on hUGT2A1
-
?
voriconazole + UDP-alpha-D-glucuronate
voriconazole D-glucuronate + UDP
-
-
-
-
?
additional information
?
-
1-hydroxybenzo(a)pyrene + UDP-glucuronate

?
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
-
-
?
1-naphthol + UDP-glucuronate

naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate

UDP + naphth-1-yl-beta-D-glucuronide
-
-
-
-
?
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
-
-
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
-
glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate

?
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
-
-
?
17beta-estradiol + UDP-glucuronate

?
-
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
17beta-estradiol + UDP-glucuronate
?
-
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine

2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
-
low activity
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, overview
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, overview
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
-
veryl low activity
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine

2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, isozyme UGT1A4 shows low activity producing N1- and N3-glucuronides, overview
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, isozyme UGT2B10 exclusively produces N3-glucuronides, overview
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate

?
-
-
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
-
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
-
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans
-
-
?
2-aminophenol + UDPglucuronate

UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-hydroxyestradiol + UDPglucuronate

UDP + 2-hydroxyestradiol O-glucuronide
-
-
-
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
-
-
?
2-hydroxyestrone + UDPglucuronate

2-hydroxyestrone 2-O-glucuronide + UDP
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
glucuronidated by UGT1A3 and HGT1A9
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
-
?
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate

UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
-
-
-
?
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
-
i.e. eugenol
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate

3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate

?
-
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate

UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxydesloratadine + UDP-glucuronate

UDP + 3-hydroxydesloratadinyl-O-glucuronide
-
specific substrate of isoform UGT1A8
-
-
?
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
-
specific substrate of isoform UGT1A8, substrate of isoform UGT1A9 mutant N152A
-
-
?
4-hydroxybiphenyl + UDP-glucuronate

UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
UGT2B7H and UGT2B7Y inactive
-
-
-
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?