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Information on EC 2.4.1.17 - glucuronosyltransferase

for references in articles please use BRENDA:EC2.4.1.17

Word Map on EC 2.4.1.17

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

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2.4.1.17

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glucuronosyltransferase

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UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

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hexosyl group transfer

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melatonin degradation I

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nicotine degradation IV

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nicotine degradation V

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saponin biosynthesis II

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serotonin degradation

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thyroid hormone metabolism II (via conjugation and/or degradation)

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Pentose and glucuronate interconversions

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Ascorbate and aldarate metabolism

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Steroid hormone biosynthesis

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Retinol metabolism

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Porphyrin and chlorophyll metabolism

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Metabolism of xenobiotics by cytochrome P450

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Drug metabolism - cytochrome P450

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Drug metabolism - other enzymes

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Metabolic pathways

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Biosynthesis of secondary metabolites

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UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)

This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

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Show Synonyms (318 entries)

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37205-52-0

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37277-52-4

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37277-66-0

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61969-98-0

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62213-43-8

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62213-47-2

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9030-08-4

-

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Manually annotated by BRENDA team

Canis lupus familiaris

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Cavia porcellus

domestic guinea pig

488729, 488741, 488744, 488747, 488748, 488750

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Manually annotated by BRENDA team

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Manually annotated by BRENDA team

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Manually annotated by BRENDA team

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Macaca fascicularis

show

rhesus monkey

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Manually annotated by BRENDA team

overview

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Manually annotated by BRENDA team

show

Mus musculus B6D2F1

UGT1A6; C57BL/6 crossed with DBA/2, gene UGT1A6

UniProt

Manually annotated by BRENDA team

Oncorhynchus mykiss

rainbow trout

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Manually annotated by BRENDA team

Oryctolagus cuniculus

show

show

-

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-

Manually annotated by BRENDA team

Pleuronectes platessa

plaice

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-

Manually annotated by BRENDA team

Rattus norvegicus

show

Rattus norvegicus Gunn

show

Rattus norvegicus R/A Pfd

R/A Pfd strain

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Manually annotated by BRENDA team

Rattus norvegicus Wistar

Wistar strain

488695, 488697, 488698, 488701, 488703, 488706, 488707, 488711, 488712, 488715, 488717, 488719, 488720, 488721, 488723, 488724, 488730, 488734, 488735, 488736, 488737, 488739, 488740, 488746, 488750, 488752, 488762, 488792

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Manually annotated by BRENDA team

Sphingomonas paucimobilis

produces gellan gum

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Manually annotated by BRENDA team

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evolution

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malfunction

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metabolism

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physiological function

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O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution

O60656, P19224, P22309, P22310

UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview; UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview

metabolism

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O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution; feedback loops between endobiotic UGT substrates and their transcription factors suggest an important role of their glucuronidation in evolution. AhR- and Nrf2-binding domains, termed XRE (xenobiotic responsive element) and ARE (antioxidant responsive element), respectively, are identified in the regulatory region of UGT1A1 and UGT1A6. The neurotransmitter serotonin is also solely glucuronidated by the human UGT1A6, which is highly expressed in the stomach and intestine. Serotonin exhibits a variety of functions in the gastrointestinal tract including gastrointestinal motility, mucosal growth/maintenance and intestinal inflammation

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. In the intestine, L-thyroxine is conjugated by UGT1A8 and UGT1A10 suggesting first-pass metabolism of oral L-thyronine, although UGT1A1 and UGT1A3 are the major UGTs glucuronidating T4 at the hydroxyl and carboxyl groups, respectively; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. In the intestine, L-thyroxine is conjugated by UGT1A8 and UGT1A10 suggesting first-pass metabolism of oral L-thyronine, although UGT1A1 and UGT1A3 are the major UGTs glucuronidating T4 at the hydroxyl and carboxyl groups, respectively; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops, proposed feedback loop between bilirubin, AhR and AhR-controlled UGT1A1. UGT1A1 is the sole enzyme conjugating bilirubin. AhR- and Nrf2-binding domains, termed XRE (xenobiotic responsive element) and ARE (antioxidant responsive element), respectively, are identified in the regulatory region of UGT1A1 and UGT1A6; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. The family 2 member UGT2B7 is regulated by Nrf2, but not by the AhR. UGT1A9- and UGT2B7-mediated detoxification of 20-hydroxyeicosatetraenoic acid to prevent hypertension. UGT1A9 and UGT2B7 appear to be major UGT enzymes responsible for 20-hydroxyeicosatetraenoic acid and leukotriene B4 glucuronidation; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. UGT1A9- and UGT2B7-mediated detoxification of 20-hydroxyeicosatetraenoic acid to prevent hypertension. UGT1A9 and UGT2B7 appear to be major UGT enzymes responsible for 20-hydroxyeicosatetraenoic acid and leukotriene B4 glucuronidation; human UDP-glucuronosyltransferases are major phase II enzymes in the drug metabolism system, they also have a role in clearance and homeostasis of endogenous substrates, UGTs are often involved in detoxification of endobiotic CYP metabolites. Species- and tissue/cell-dependent regulation of UGT expression by ligand-activated transcription factors is often involved in endobiotic homeostasis. All UGT1 family members appear to be controlled by the AhR transcription factor. Bilirubin and 20-hydroxyeicosatetraenoic acid act as activators of transcription factors that regulate UGT expression, and are involved in important feedback loops. UGT2B28 is involved in estradiol and testosterone glucuronidation in a variety of tissues including breast cells

O60656, P16662, P22309, P22310

metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues; metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues; metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues; metabolic function of UGTs can be severely influenced by hepatocellular carcinoma, analysis of alteration on the metabolism of UGTs specific substrates, translational and transcriptional activity of UGTs in hepatitis B virus-positive hepatocellular carcinoma patients, overview. In the tumor human liver microsomes, either Vmax or the clearance rates of UGT1A, UGT1A1, UGT1A4, UGT1A9 and UGT2B7 are significant lower than those of in the adjacent normal human liver microsomes. Protein and gene expressions of these isoforms are decreased in most of tumor tissues compared to the adjacent healthy tissues

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(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate

? + UDP

show the reaction diagram

-

substrate for isoforms UGT1A9 and UGT1A10

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-

?

(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate

? + UDP

show the reaction diagram

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substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10

-

-

?

(-)-borneol + UDP-glucuronate

UDP + (-)-borneol-O-alpha-D-glucuronide

show the reaction diagram

Rattus norvegicus

P08541, P20720, Q62789, Q64638

-

-

-

?

(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate

(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

(R)-propanolol + UDP-glucuronate

UDP + (R)-propanolol O-glucuronide

show the reaction diagram

-

-

-

-

?

(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate

(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

(S)-naproxen + UDP-alpha-D-glucuronate

beta-D-glucuronosyl (S)-naproxen + UDP

show the reaction diagram

-

-

-

-

?

(S)-naproxen + UDP-alpha-D-glucuronate

UDP + beta-D-glucuronosyl (S)-naproxen

show the reaction diagram

-

-

-

-

?

(S)-propanolol + UDP-glucuronate

UDP + (S)-propanolol O-glucuronide

show the reaction diagram

-

-

-

-

?

1-hydroxy-benzo(a)pyrene + UDP-glucuronate

1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

1-hydroxybenzo(a)pyrene + UDP-glucuronate

?

show the reaction diagram

show

1-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-1-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

1-hydroxypyrene + UDP-glucuronate

1-hydroxypyrene 1-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

1-hydroxypyrene + UDP-glucuronate

?

show the reaction diagram

-

-

-

?

1-hydroxy[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide

show the reaction diagram

-

-

-

-

?

1-naphthol + UDP-alpha-D-glucuronate

1-naphthyl O-glucuronide + UDP

show the reaction diagram

Rattus norvegicus

-

-

-

-

?

1-naphthol + UDP-alpha-D-glucuronate

1-naphthyl-O-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

1-naphthol + UDP-glucuronate

1-naphthyl 1-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

1-naphthol + UDP-glucuronate

1-naphthyl-O-glucuronide + UDP

show the reaction diagram

O75795, P16662, P22309, P35503, P54855

-

-

-

?

1-naphthol + UDP-glucuronate

?

show the reaction diagram

P22310, P35503, Q9HAW7

-

-

-

?

1-naphthol + UDP-glucuronate

naphth-1-yl-beta-D-glucuronide + UDP

show the reaction diagram

show

1-naphthol + UDP-glucuronate

UDP + naphth-1-yl-beta-D-glucuronide

show the reaction diagram

show

10-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-10-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

11-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-11-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

11alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 11alpha-hydroxyprogesterone-11-O-alpha-D-glucuronate

show the reaction diagram

-

-

-

?

12-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-12-yl-beta-D-glucuronide

show the reaction diagram

show

12-hydroxyeicosatetraenoic acid + UDP-glucuronate

?

show the reaction diagram

O75310, P06133, P36537

-

-

-

?

13-hydroxyoctadecadienoic acid + UDP-glucuronate

?

show the reaction diagram

O75310, P06133, P36537

-

-

-

?

16alpha-hydroxyprogesterone + UDP-glucuronate

?

show the reaction diagram

show

16alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 16alpha-hydroxyprgesterone-16-O-alpha-D-glucuronate

show the reaction diagram

UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation

-

-

?

16alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 16alpha-hydroxyprogesteron-16-O-alpha-D-glucuronate

show the reaction diagram

-

-

-

?

17-epiestriol + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

17-epiestriol + UDP-glucuronate

UDP + ?

show the reaction diagram

-

-

-

-

?

17alpha-estradiol + UDP-alpha-D-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

17alpha-ethynylestradiol + UDP-glucuronate

UDP + 17alpha-ethynylestradiol 3-O-beta-D-glucuronide

show the reaction diagram

-

-

-

?

17beta-estradiol + UDP-alpha-D-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

17beta-estradiol + UDP-glucuronate

?

show the reaction diagram

show

17beta-ethynylestradiol + UDPglucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

17beta-hydroxy-5alpha-androstan-3-one + UDPglucuronate

UDP + 17beta-hydroxy-5alpha-androstan-3-one 17O-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

2 UDP-D-glucuronate + 2 dexmedetomidine

2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside

show the reaction diagram

show

2 UDP-D-glucuronate + 2 levomedetomidine

2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside

show the reaction diagram

show

2',4,4'-trihydroxychalcone + UDP-glucuronate

UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside

show the reaction diagram

-

i.e. isoliquiritigenin

-

-

?

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate

?

show the reaction diagram

show

2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate

?

show the reaction diagram

-

glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans

-

-

?

2-aminobenzoate + UDPglucuronate

UDP + ?

show the reaction diagram

Cavia porcellus

-

-

-

-

?

2-aminobiphenyl + UDP-glucuronate

?

show the reaction diagram

P22310, P35503, Q9HAW7

-

-

-

?

2-aminophenol + UDPglucuronate

UDP + (2-aminophenyl)-O-glucuronide

show the reaction diagram

show

2-hydroxy-2',3',4',5'-tetrachlorobiphenyl + UDPglucuronate

UDP + 2',3',4',5'-tetrachlorobiphenyl 2-O-glucuronate

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

2-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-2-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

2-hydroxyestradiol + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

2-hydroxyestradiol + UDPglucuronate

UDP + 2-hydroxyestradiol O-glucuronide

show the reaction diagram

show

2-hydroxyestrone + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

2-hydroxyestrone + UDPglucuronate

2-hydroxyestrone 2-O-glucuronide + UDP

show the reaction diagram

show

2-methoxy-4-(2-propenyl)phenol + UDPglucuronate

UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide

show the reaction diagram

show

21-hydroxyprogesterone + UDP-glucuronate

UDP + 21-hydroxyprogesterone-21-O-alpha-D-glucuronate

show the reaction diagram

-

-

-

?

3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate

3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP

show the reaction diagram

-

substrate of isoform UGT2B7

-

-

?

3'-azido-3'-deoxythymidine + UDPglucuronate

3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP

show the reaction diagram

show

3,5-dinitrocatechol + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

3-azido-4-chlorobenzoic acid + UDP-glucuronate

?

show the reaction diagram

-

-

-

?

3-azidobenzoic acid + UDP-glucuronate

?

show the reaction diagram

-

-

-

?

3-hydroxy-benzo(a)pyrene + UDP-glucuronate

3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

3-hydroxybenzo(a)pyrene + UDP-glucuronate

?

show the reaction diagram

show

3-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-3-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

3-hydroxybenzo[a]pyrene + UDPglucuronate

UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide

show the reaction diagram

show

3-hydroxydesloratadine + UDP-glucuronate

UDP + 3-hydroxydesloratadinyl-O-glucuronide

show the reaction diagram

show

4-aminobiphenyl + UDP-glucuronate

UDP + 4-aminobiphenyl N-glucuronide

show the reaction diagram

-

-

-

-

?

4-aminobiphenyl + UDPglucuronate

UDP + ?

show the reaction diagram

-

catalyzed by isozyme 1 but not by isozyme 2

-

-

?

4-azido-2-hydroxybenzoic acid + UDPglucuronate

?

show the reaction diagram

-

-

-

?

4-azidobenzoic acid + UDP-glucuronate

?

show the reaction diagram

-

-

-

?

4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl + UDPglucuronate

UDP + 2,3,3',4',5'-pentachlorobiphenyl 4-O-glucuronate

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

4-hydroxy-2',3,3',4',5,5'-heptachlorobiphenyl + UDPglucuronate

UDP + 2',3,3',4',5,5'-hexachlorobiphenyl 4-O-glucuronate

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl + UDPglucuronate

UDP + 2',3,4',5,6'-pentachlorobiphenyl 4-O-glucuronate

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

4-hydroxy-2',3,4',6'-tetrachlorobiphenyl + UDP-glucuronate

UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

4-hydroxy-2',4',6'-trichlorobiphenyl + UDP-glucuronate

UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

4-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-4-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

4-hydroxybiphenyl + UDP-glucuronate

UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide

show the reaction diagram

show

4-hydroxybiphenyl + UDPglucuronate

UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide

show the reaction diagram

show

4-hydroxyestradiol + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

4-hydroxyestradiol + UDPglucuronate

UDP + 4-hydroxyestradiol O-glucuronide

show the reaction diagram

show

4-hydroxyestrone + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

4-hydroxyestrone + UDP-glucuronate

UDP + 4-hydroxyestrone 4-O-glucuronide

show the reaction diagram

show

4-hydroxyestrone + UDP-glucuronate

UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide

show the reaction diagram

-

-

-

-

?

4-methylumbeliferone + UDP-alpha-D-glucuronate

4-methylumbelliferyl-7-O-alpha-D-glucuronide

show the reaction diagram

-

-

-

-

?

4-methylumbeliferone + UDP-glucuronate

4-methylumbelliferyl-7-O-alpha-D-glucuronide

show the reaction diagram

show

4-methylumbeliferone + UDP-glucuronate

4-methylumbelliferyl-7-O-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

4-methylumbelliferone + UDP-glucuronate

UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide

show the reaction diagram

show

4-n-octylgallate + UDPglucuronate

UDP + 4-n-octylgallate 3-O-glucuronide

show the reaction diagram

Oryctolagus cuniculus

-

highly specific for UGT1A71

-

?

4-nitrophenol + UDP-glucuronate

4-nitrophenyl beta-D-glucuronide + UDP

show the reaction diagram

show

4-nitrothiophenol + UDP-glucuronate

4-nitrothiophenyl thio-beta-D-glucuronide + UDP

show the reaction diagram

show

5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate

5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP

show the reaction diagram

-

i.e. antitumor agent C-1311, NSC-645809

-

-

?

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate

5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP

show the reaction diagram

-

i.e. antitumor agent C-1305

-

-

?

5-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-5-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

5-hydroxybenzo[a]pyrene + UDPglucuronate

UDP + 5-hydroxybenzo[a]pyrene O-glucuronide

show the reaction diagram

-

glucuronidated by UGT1A3

-

?

5-methylchrysene-1,2-diol + UDP-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate

?

show the reaction diagram

O75310, P06133, P36537

-

-

-

?

5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate

UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide

show the reaction diagram

show

5beta-androstane-3alpha,17beta-diol + UDP-glucuronate

UDP + 5beta-androstane-3alpha,17beta-diol O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

6-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-6-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

6-hydroxywarfarin + UDP-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

6alpha-hydroxyprogesterone + UDP-glucuronate

UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate

show the reaction diagram

-

-

-

?

7,7,7-triphenylheptanoic acid + UDPglucuronate

UDP + 7,7,7-triphenylheptanoic acid glucuronide

show the reaction diagram

show

7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate

UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate

show the reaction diagram

show

7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate

UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate

show the reaction diagram

show

7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate

7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP

show the reaction diagram

show

7-hydroxy benzo(a)pyrene + UDP-glucuronate

?

show the reaction diagram

show

7-hydroxy-4-(trifluoromethyl)-coumarin + UDPglucuronate

UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide

show the reaction diagram

-

-

-

?

7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate

7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP

show the reaction diagram

show

7-hydroxy-benzo(a)pyrene + UDP-glucuronate

7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

7-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-7-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

7-hydroxycoumarin + UDP-glucuronate

UDP + coumarin-7-yl-alpha-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

7-hydroxywarfarin + UDP-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

8-hydroxy-benzo(a)pyrene + UDP-glucuronate

8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

8-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-8-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

8-hydroxyquinoline + UDPglucuronate

UDP + 8-hydroxyquinoline 8-O-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

8-hydroxywarfarin + UDP-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

9-hydroxybenzo(a)pyrene + UDP-glucuronate

?

show the reaction diagram

show

9-hydroxybenzo[a]pyrene + UDP-glucuronate

UDP + benzo[a]pyren-9-yl-beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

acetaminophen + UDP-glucuronate

?

show the reaction diagram

show

alpha-naphthylamine + UDPglucuronate

UDP + ?

show the reaction diagram

show

alprazolam + UDP-alpha-D-glucuronate

alprazolam D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

amitriptyline + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

androstane-3alpha,17beta diol + UDPglucuronate

UDP + androstane-3alpha,17beta diol O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

androsterone + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

P08541, P20720, Q62789, Q64638

-

-

-

?

androsterone + UDPglucuronate

UDP + androsterone O-glucuronide

show the reaction diagram

show

anthraflavic acid + UDPglucuronate

UDP + ?

show the reaction diagram

show

apigenin + UDPglucuronate

UDP + apigenin O-glucuronide

show the reaction diagram

show

benzo(a)pyrene-7,8-diol + UDP-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

benzo[a]pyrene 3,6-diphenol + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

converted readily to mono- and diglucuronides

-

-

?

benzo[a]pyrene 3,6-quinone + UDPglucuronate

benzo[a]pyrene 3,6-quinol glucuronide + UDP

show the reaction diagram

Rattus norvegicus

-

-

no information to which positions 3-, 6-, or both the glucuronate is attached

?

benzo[a]pyrene-3,6-quinol + UDPglucuronate

benzo[a]pyrene 3,6-quinol mono- and diglucuronide + UDP

show the reaction diagram

Rattus norvegicus

-

-

-

?

benzo[a]pyrene-7,8(+)-diol + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

benzo[a]pyrene-7,8(-)diol + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

beta-estradiol + UDP-alpha-D-glucuronate

beta-estradiol-3-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

beta-estradiol + UDPglucuronate

beta-estradiol-3-glucuronide + UDP

show the reaction diagram

show

bifonazole + UDP-alpha-D-glucuronate

bifonazole D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

bilirubin + UDP-glucuronate

?

show the reaction diagram

P22310, P35503, Q9HAW7

-

-

-

?

bilirubin + UDP-glucuronate

bilirubin D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

bilirubin + UDP-glucuronate

bilirubin glucuronoside + UDP

show the reaction diagram

-

UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)

-

-

?

bilirubin + UDPglucuronate

bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP

show the reaction diagram

show

bilirubin + UDPglucuronate

UDP + bilirubin O-glucuronide

show the reaction diagram

show

bilirubin monoglucuronide + UDPglucuronate

bilirubin diglucuronide + UDP

show the reaction diagram

show

bisphenol A + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

borneol + UDPglucuronate

UDP + borneol O-glucuronide

show the reaction diagram

show

buprenorphine + UDPglucuronate

UDP + buprenorphine O-glucuronide

show the reaction diagram

show

cannabinol + UDP-glucuronate

? + UDP

show the reaction diagram

-

substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10

-

-

?

carvacrol + UDP-glucuronate

caervcrol O-glucuronate + UDP

show the reaction diagram

-

isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes

-

-

?

chenodeoxycholic acid + UDP-glucuronate

UDP + ?

show the reaction diagram

show

chenodeoxycholic acid + UDPgalacturonate

UDP + chenodeoxycholic acid O-galacturonide

show the reaction diagram

Rattus norvegicus

-

-

-

?

chloramphenicol + UDPglucuronate

UDP + chloramphenicol O-glucuronide

show the reaction diagram

show

cholic acid + UDPglucuronate

cholic acid O-glucuronide

show the reaction diagram

-

-

-

?

chrysin + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

clofibrate + UDPglucuronate

UDP + ?

show the reaction diagram

show

codeine + UDPglucuronate

codeine-6-glucuronide + UDP

show the reaction diagram

-

glucuronidated by HGT2B7H and HGT2B7Y

-

-

deferiprone + UDP-glucuronate

deferiprone 3-O-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

deoxycholic acid + UDPglucuronate

UDP + deoxycholic acid O-glucuronide

show the reaction diagram

-

-

-

?

dibenzo(a,l)pyrene-11,12-diol + UDP-glucuronate

? + UDP

show the reaction diagram

-

-

-

-

?

diclofenac + UDP-alpha-D-glucuronate

diclofenac D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

diclofenac + UDPalpha-D-glucuronate

UDP + ?

show the reaction diagram

show

digitoxigenin + UDPglucuronate

UDP + digitoxigenin O-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

dihydromorphine + UDPglucuronate

UDP + dihydromorphine O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

dihydromorphone + UDPglucuronate

UDP + dihydromorphone O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

dihydrotestosterone + UDP-alpha-D-glucuronate

dihydrotestosterone D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

dihydrotestosterone + UDPglucuronate

UDP + dihydrotestosterone O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

econazole + UDP-alpha-D-glucuronate

econazole D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

edaravone + UDP-alpha-D-glucuronate

edaravone beta-D-glucuronate + UDP

show the reaction diagram

-

i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7

-

-

?

epicatechin + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

epitestosterone + UDP-glucuronate

UDP + epitestosterone 17-O-glucuronide

show the reaction diagram

show

epitestosterone + UDP-glucuronate

UDP + epitestosterone O-glucuronide

show the reaction diagram

-

glucuronidated by HGT2B7H and HGT2B7Y

-

?

estradiol + UDP-alpha-D-glucuronate

estradiol 3-O-glucuronate + UDP

show the reaction diagram

Macaca fascicularis

sigmoidal kinetics with n of 1.7

-

-

?

estradiol + UDP-alpha-D-glucuronate

UDP + estradiol 3-O-glucuronide

show the reaction diagram

-

substrate of isoform UGT1A1

-

-

?

estradiol + UDP-glucuronate

?

show the reaction diagram

show

estradiol + UDP-glucuronate

estradiol 3-O-glucuronate + UDP

show the reaction diagram

sigmoidal kinetics with n of 1.7

-

-

?

estradiol + UDPglucuronate

UDP + estradiol O-glucuronide

show the reaction diagram

-

-

-

?

estradiol-17alpha + UDPglucuronate

UDP + 17-alpha-estradiol O-glucuronide

show the reaction diagram

-

-

-

?

estradiol-17beta + UDPglucuronate

estradiol-17beta-3-monoglucuronide + UDP

show the reaction diagram

show

estriol + UDP-glucuronate

?

show the reaction diagram

show

estriol + UDPglucuronate

UDP + estriol-16 alpha-glucuronide

show the reaction diagram

show

estrogen + UDP-glucuronate

?

show the reaction diagram

show

estrone + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

estrone + UDPglucuronate

UDP + estrone 3-O-glucuronide

show the reaction diagram

show

ethinylestradiol + UDPglucuronate

UDP + ethinylestradiol-3-glucuronide

show the reaction diagram

-

-

-

?

etiocholanone + UDPglucuronate

UDP + etiocholanone O-glucuronide

show the reaction diagram

show

etoposide + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

etoposide + UDP-glucuronate

UDP + etoposide glucuronide

show the reaction diagram

show

eugenol + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

eugenol + UDP-glucuronate

UDP + eugenol-O-alpha-D-glucuronide

show the reaction diagram

-

-

-

-

?

fluconazole + UDP-alpha-D-glucuronate

fluconazole D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

flurbiprofen + UDP-glucuronate

?

show the reaction diagram

-

metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7

-

-

?

frusemide + UDP-alpha-D-glucuronate

frusemide D-glucuronide

show the reaction diagram

-

-

-

-

?

glycolithocholic acid + UDPglucuronate

UDP + glycolithocholic acid O-glucuronide

show the reaction diagram

-

lowest activity among five bile acids studied

-

?

hyodeoxycholic acid + UDP-glucuronate

?

show the reaction diagram

show

hyodeoxycholic acid + UDPglucuronate

UDP + hyodeoxycholic acid O-glucuronide

show the reaction diagram

show

ibuprofen + UDPglucuronate

UDP + ?

show the reaction diagram

show

imipramine + UDPglucuronate

UDP + ?

show the reaction diagram

show

itraconazole + UDP-alpha-D-glucuronate

?

show the reaction diagram

-

-

-

-

?

ketoconazole + UDP-alpha-D-glucuronate

?

show the reaction diagram

-

-

-

-

?

lamotrigine + UDP-alpha-D-glucuronate

lamotrigine D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

lamotrigine + UDP-glucuronate

UDP + ?

show the reaction diagram

-

-

-

-

?

lithocholic acid + UDPglucuronate

UDP + ?

show the reaction diagram

show

lorazepam + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

miconazole + UDP-alpha-D-glucuronate

miconazole D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

midazolam + UDP-alpha-D-glucuronate

midazolam D-glucuronide + UDP

show the reaction diagram

-

-

-

-

?

milnacipran + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

morphine + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

P08541, P20720, Q62789, Q64638

-

-

-

?

morphine + UDP-glucuronate

UDP + morphine 3,6-diglucuronide

show the reaction diagram

show

morphine + UDP-glucuronate

UDP + morphine 3-glucuronide + morphine 6-glucuronide

show the reaction diagram

-

-

-

-

?

mycophenolate + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

mycophenolic acid + UDP-alpha-D-glucuronate

mycophenolic acid D-glucuronide

show the reaction diagram

-

-

-

-

?

N-hydroxy-2-acetylaminofluorene + UDPglucuronate

UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide

show the reaction diagram

-

glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives

-

?

N-hydroxy-2-naphthylamine + UDPglucuronate

UDP + N-hydroxy-2-naphthylamine-O-glucuronide

show the reaction diagram

show

nalorphine + UDPglucuronate

UDP + nalorphine O-glucuronate

show the reaction diagram

Macaca fascicularis

-

-

-

?

naloxone + UDPglucuronate

UDP + naloxone O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

naltrexone + UDPglucuronate

UDP + naltrexone O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

octylgallate + UDPglucuronate

?

show the reaction diagram

P22310, P35503, Q9HAW7

-

-

-

?

olanzapine + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

opiates + UDPglucuronate

opiates 6-O-glucuronides + UDP

show the reaction diagram

-

substrate for UGT2B7

-

-

oxazepam + UDP-glucuronate

?

show the reaction diagram

-

-

-

-

?

oxymorphone + UDPglucuronate

UDP + oxymorphone O-glucuronide

show the reaction diagram

Macaca fascicularis

-

-

-

?

p,p'-biphenyl + UDPglucuronate

UDP + ?

show the reaction diagram

Macaca fascicularis

-

-

-

-

?

p-ethoxyphenylurea + UDP-glucuronate

?

show the reaction diagram

P22310, P35503, Q9HAW7

-

-

-

?

phenolphthalein + UDPglucuronate

UDP + phenolphthalein O-glucuronide

show the reaction diagram

show

planar phenols + UDPglucuronate

UDP + phenylglucuronides

show the reaction diagram

Rattus norvegicus

-

expressed before birth

-

-

-

profen + UDPglucuronate

UDP + ?

show the reaction diagram

show

propofol + UDP-alpha-D-glucuronate

propofol D-glucuronide

show the reaction diagram

-

-

-

-

?

propofol + UDP-alpha-D-glucuronate

UDP + estradiol O-glucuronide

show the reaction diagram

-

substrate of isoform UGT1A9

-

-

?

propofol + UDP-glucuronate

UDP + propofyl beta-D-glucuronide

show the reaction diagram

Rattus norvegicus

-

-

-

?

quercetin + UDPglucuronate

UDP + quercetin O-glucuronide

show the reaction diagram

show

retigabine + UDP-alpha-D-glucuronate

retigabine D-glucuronide

show the reaction diagram

-

-

-

-

?

retigabine + UDP-glucuronate

UDP + retigabine N-glucuronide

show the reaction diagram

-

-

-

-

?

scopoletin + UDP-glucuronate

?

show the reaction diagram

P22310, P35503, Q9HAW7

-

-

-

?

scopoletin + UDP-glucuronate

UDP + scopoletin O-glucoside

show the reaction diagram

very low rate of glucuronidation

-

-

?

scopoletin + UDP-glucuronate

UDP + scopoletin O-glucuronide

show the reaction diagram

-

-

-

-

?

scopoletin + UDPglucuronate

UDP + scopoletin O-glucuronide

show the reaction diagram

show

senecionine + UDP-alpha-D-glucuronate

senecionine N-glucuronide + UDP

show the reaction diagram

-

senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics

-

-

?

serotonin + UDP-glucuronate

?

show the reaction diagram

Rattus norvegicus

-

-

-

?

serotonin + UDP-glucuronate

UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide

show the reaction diagram

show

serotonin + UDPglucuronate

tryptamine 5-O-beta-D-glucuronide + UDP

show the reaction diagram

show

sulconazole + UDP-alpha-D-glucuronate

sulconazole D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

sulfinpyrazone + UDP-alpha-D-glucuronate

sulfinpyrazone D-glucuronide

show the reaction diagram

-

-

-

-

?

tamoxifen + UDP-alpha-D-glucuronate

tamoxifen-N-glucuronate + UDP

show the reaction diagram

-

-

-

-

-

tamoxifen + UDP-glucuronate

UDP + ?

show the reaction diagram

-

-

-

-

?

testosterone + UDP-glucuronate

?

show the reaction diagram

show

testosterone + UDP-glucuronate

UDP + testosterone 17-O-glucuronide

show the reaction diagram

-

isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics

-

-

?

testosterone + UDP-glucuronate

UDP + testosterone-17-O-alpha-D-glucuronate

show the reaction diagram

-

-

-

?

testosterone + UDP-glucuronate

UDP + testosterone-17alpha-glucuronide

show the reaction diagram

Rattus norvegicus

P08430, P08542, P09875, P36511, Q64550, Q64633, Q64637

-

-

-

?

testosterone + UDPglucuronate

UDP + testosterone O-glucuronide

show the reaction diagram

show

thiophenol + UDPglucuronate

thiophenyl thio-beta-D-glucuronide + UDP

show the reaction diagram

show

tioconazole + UDP-alpha-D-glucuronate

tioconazole D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

tranilast + UDP-glucuronate

tranilast glucuronoside + UDP

show the reaction diagram

-

-

-

-

?

trans-4-hydroxytamoxifen + UDP-glucuronate

UDP + ?

show the reaction diagram

-

-

-

-

?

trans-androsterone + UDP-alpha-D-glucuronate

trans-androsterone D-glucuronate + UDP

show the reaction diagram

-

-

-

-

?

trans-endoxifen + UDP-glucuronate

UDP + ?

show the reaction diagram

-

-

-

-

?

trifluoperazine + UDP-glucuronate

UDP + ?

show the reaction diagram

-

substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P

-

-

?

troglitazone + UDPglucuronate

UDP + troglitazone 6-O-glucuronide

show the reaction diagram

show

UDP-alpha-D-glucuronate + (R)-propranolol

UDP + (R)-propranolol beta-D-glucuronoside

show the reaction diagram

show

UDP-alpha-D-glucuronate + (S)-naproxen

UDP + beta-D-glucuronosyl (S)-naproxen

show the reaction diagram

show

UDP-alpha-D-glucuronate + (S)-propranolol

UDP + (S)-propranolol beta-D-glucuronoside

show the reaction diagram

show

UDP-alpha-D-glucuronate + 3-hydroxyflavone

UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone

show the reaction diagram

isozyme UGT1A1

-

-

?

UDP-alpha-D-glucuronate + diclofenac

UDP + diclofenac O-beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-alpha-D-glucuronate + dopamine

UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid

show the reaction diagram

-

substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested

-

-

?

UDP-alpha-D-glucuronate + dopamine

UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid

show the reaction diagram

-

-

substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested

-

?

UDP-alpha-D-glucuronate + sorafenib

UDP + ?

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-alpha-glucuronate + diclofenac

UDP + beta-D-glucuronosyl-diclofenac

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 1-naphthol

UDP + 1-naphthyl beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 11alpha-hydroxyprogesterone

UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside

show the reaction diagram

an UGT2B7 substrate

-

-

?

UDP-D-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol 3-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

?

UDP-D-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol-3-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3

UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside

show the reaction diagram

among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview

-

-

?

UDP-D-glucuronate + 2-hydroxyestradiol

UDP + 2-hydroxyestradiol beta-D-glucuronoside

show the reaction diagram

isozyme UGT1A1

-

-

?

UDP-D-glucuronate + 2-hydroxyestrone

UDP + 2-hydroxyestrone beta-D-glucuronoside

show the reaction diagram

isozyme UGT1A1

-

-

?

UDP-D-glucuronate + 2-naphthol

UDP + 2-naphthyl beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 3'-azido-3'-deoxythymidine

UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside

show the reaction diagram

model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview

-

-

?

UDP-D-glucuronate + 3-hydroxydesloratadine

UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside

show the reaction diagram

-

specific substrate of isozyme UGT1A8

-

-

?

UDP-D-glucuronate + 4'-hydroxy-warfarin

UDP + 4'-hydroxy-warfarin beta-D-glucuronoside

show the reaction diagram

substrate of isozyme UGT1A10

-

-

?

UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone

UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 4-hydroxy-estrone

UDP + ?

show the reaction diagram

-

-

-

?

UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen

UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferone beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferonyl beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl beta-O-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl beta-O-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl O-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol

UDP + ?

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + 6-hydroxy-warfarin

UDP + 6-hydroxy-warfarin beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 7-hydroxy-warfarin

UDP + 7-hydroxy-warfarin beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + 8-hydroxy-warfarin

UDP + 8-hydroxy-warfarin beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + acacetin

UDP + acacetin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + acceptor

UDP + acceptor beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + androstane-3alpha,17beta-diol

UDP + ?

show the reaction diagram

show

UDP-D-glucuronate + androsterone

UDP + androsterone 3-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + anthraflavic acid

UDP + ?

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + apigenin

UDP + apigenin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + beta-D-estradiol

UDP + beta-estradiol 3-O-beta-D-glucuronoside

show the reaction diagram

isozyme UGT1A1

-

-

?

UDP-D-glucuronate + beta-estradiol

UDP + beta-estradiol 3-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + bilirubin

UDP + ?

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + bilirubin

UDP + bilirubin beta-D-glucuronoside

show the reaction diagram

isozyme UGT1A1

-

-

?

UDP-D-glucuronate + bisdemethoxy-curcumin

UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + candesartan

UDP + candesartan beta-D-glucuronoside

show the reaction diagram

-

isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide

-

-

?

UDP-D-glucuronate + capsaicin

UDP + capsaicin beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + chenodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

show the reaction diagram

isozyme UGT2A3

-

-

?

UDP-D-glucuronate + cis-4-hydroxytamoxifen

UDP + 4-hydroxytamoxifen beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + cotinine

UDP + ?

show the reaction diagram

show

UDP-D-glucuronate + curcumin

UDP + curcumin beta-D-glucuronoside

show the reaction diagram

-

low activity, can reverse the inhibtory effect of curcumin on UGTs

-

-

?

UDP-D-glucuronate + curcumin

UDP + curcumin phenolic beta-D-monoglucuronide

show the reaction diagram

show

UDP-D-glucuronate + dehydrotestosterone

UDP + dehydrotestosterone 17-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + demethoxy-curcumin

UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + deoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

show the reaction diagram

isozyme UGT2A3

-

-

?

UDP-D-glucuronate + dihydrotestosterone

UDP + dihydrotestosterone 17-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + eriodictyol

UDP + eriodictyol 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + estradiol

UDP + estradiol 3-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + estradiol

UDP + estradiol-3-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + estriol

UDP + ?

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + estriol

UDP + estriol 3-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + estriol

UDP + estriol glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + eugenol

UDP + eugenol beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + flurbiprofen

UDP + flurbiprofen beta-D-glucuronoside

show the reaction diagram

-

isozyme UGT2B7

-

-

?

UDP-D-glucuronate + frusemide

UDP + frusemide beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + gemfibrozil

UDP + gemfibrozil beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + hesperetin

UDP + hesperetin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + homoeriodictyol

UDP + homoeriodictyol 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 24-carboxy-glucuronoside

show the reaction diagram

recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation

product formation depends on the isozyme, overview

-

?

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 3-O-glucuronoside

show the reaction diagram

recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation

product formation depends on the isozyme, overview

-

?

UDP-D-glucuronate + hyodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + imipramine

UDP + imipramine N-beta-D-glucuronoside

show the reaction diagram

-

reaction of isozyme UGT1A4

-

-

?

UDP-D-glucuronate + isolongifolol

UDP + isolongifolol beta-D-glucuronoside

show the reaction diagram

-

the compound is substrate and competitive inhibitor

-

-

?

UDP-D-glucuronate + kaempferol

UDP + kaempferol 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + labetalol

UDP + ?

show the reaction diagram

show

UDP-D-glucuronate + longifolol

UDP + longifolol beta-D-glucuronoside

show the reaction diagram

-

the compound is substrate and competitive inhibitor

-

-

?

UDP-D-glucuronate + losartan

UDP + losartan beta-D-glucuronoside

show the reaction diagram

-

no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring

-

-

?

UDP-D-glucuronate + luteolin

UDP + luteolin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + menadiol

UDP + mendadiol 1-O-beta-D-glucuronoside

show the reaction diagram

-

-

isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1

-

?

UDP-D-glucuronate + menadiol

UDP + mendadiol 4-O-beta-D-glucuronoside

show the reaction diagram

-

-

isoform UGT1A10, preferential formation of 4-menadiol glucuronoside, isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1

-

?

UDP-D-glucuronate + morphine

UDP + morphine 3-beta-D-glucuronoside

show the reaction diagram

-

activity of isozyme UGT1A8

-

-

?

UDP-D-glucuronate + morphine

UDP + morphine 3-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + morphine

UDP + morphine 6-beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + morphine

UDP + morphine 6-O-beta-D-glucuronoside

show the reaction diagram

D2SML9, D2SMM0, D2SMM1, D2SMM2, D2SMM3, D2SMM4, D2SMM5, D2SMM6

-

-

-

?

UDP-D-glucuronate + mycophenolate

UDP + ?

show the reaction diagram

show

UDP-D-glucuronate + mycophenolic acid

UDP + mycophenolic acid beta-D-glucuronoside

show the reaction diagram

-

K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview

-

-

?

UDP-D-glucuronate + myricetin

UDP + myricetin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + naringenin

UDP + naringenin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + nicotine

UDP + ?

show the reaction diagram

show

UDP-D-glucuronate + octylgallate

UDP + octylgallate beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + phenolphthalein

UDP + phenolphthalein beta-D-glucuronoside

show the reaction diagram

an UGT2B15 substrate

-

-

?

UDP-D-glucuronate + phenolphthalein

UDP + phenolphthalein beta-D-monoglucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + phloretin

UDP + ?

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + propofol

UDP + propofol beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + protocatechuic aldehyde

UDP + ?

show the reaction diagram

show

UDP-D-glucuronate + quercetin

UDP + quercetin 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + scopoletin

UDP + scopoletin beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + serotonin

UDP + serotonin beta-D-glucuronoside

show the reaction diagram

isozyme UGT1A6

-

-

?

UDP-D-glucuronate + serotonin

UDP + serotonin O-beta-D-glucuronoside

show the reaction diagram

-

reaction of isozyme UGT1A6

-

-

?

UDP-D-glucuronate + tamoxifen + H+

UDP + tamoxifen beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + testosterone

UDP + testosterone 17-O-beta-D-glucuronoside

show the reaction diagram

an UGT2B15 substrate

-

-

?

UDP-D-glucuronate + thyroxine

UDP + thyroxine beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + trans-4-hydroxytamoxifen

UDP + 4-hydroxytamoxifen beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + trifluoperazine

UDP + trifluoperazine beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + umbelliferone

UDP + umbelliferyl beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-D-glucuronate + ursodeoxycholic acid

UDP + hyodeoxycholic acid 6-O-glucuronoside

show the reaction diagram

isozyme UGT2A3

-

-

?

UDP-D-glucuronate + zidovudine

UDP + zidovudine beta-D-glucuronoside

show the reaction diagram

show

UDP-D-glucuronate + zolarsartan

UDP + zolarsartan beta-D-glucuronoside

show the reaction diagram

-

isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7

-

-

?

UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime

UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate

show the reaction diagram

show

UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid

UDP + ?

show the reaction diagram

-

i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9

-

-

?

UDP-glucuronate + (S)-oxazepam

UDP + (S)-oxazepam beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 1,25-dihydroxyergocalciferol

UDP + 1,25-dihydroxyergocalciferol beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 1-hydroxypyrene

UDP + 1-hydroxypyrene beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 1-naphthol

UDP + 1-naphthol beta-D-glucuronide

show the reaction diagram

show

UDP-glucuronate + 1-naphthol

UDP + beta-D-glucuronosyl-(1-naphthol)

show the reaction diagram

show

UDP-glucuronate + 10-gingerol

UDP + 10-gingerol 4'-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 10-gingerol

UDP + 10-gingerol 5-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 10-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 12-hydroxyeicosatetraenoic acid

UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 12-hydroxyeicosatetraenoic acid

UDP + 12-hydroxyeicosatetraenoyl-beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 15-hydroxyeicosatetraenoic acid

UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 15-hydroxyeicosatetraenoic acid

UDP + 15-hydroxyeicosatetraenoyl-beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 17-alpha-estradiol

UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 17-beta-estradiol

UDP + 17-beta-estradiol 3-beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 17-beta-estradiol

UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 17beta-estradiol

UDP + 17beta-estradiol 3-O-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 17beta-estradiol

UDP + estradiol 17-beta-D-glucuronide

show the reaction diagram

O60656, P16662, P22309, P35503, P54855

-

-

-

?

UDP-glucuronate + 2',4'-dihydroxychalcone

UDP + 2'-hydroxychalcone 4'-O-beta-D-glucuronoside

show the reaction diagram

-

glucuronidation at the OH-4' position by UGT1A1 and UGT1A10 isoforms, both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide

-

-

?

UDP-glucuronate + 2',4'-dihydroxychalcone

UDP + 4'-hydroxychalcone 2'-O-beta-D-glucuronoside

show the reaction diagram

-

glucuronidation at the OH-2' position with low activity by UGT1A7, UGT1A6, and UGT1A10 isoforms, and with high activity by isozyme UGT1A9. Both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide

-

-

?

UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone

?

show the reaction diagram

show

UDP-glucuronate + 2'-hydroxychalcone

UDP + chalcone 2'-O-beta-D-glucuronoside

show the reaction diagram

-

glucuronidation at the OH-2' position by UGT1A9 isoform

-

-

?

UDP-glucuronate + 2-hydroxyestrone

UDP + 2-hydroxyestrone beta-D-glucuronide

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 2-methoxyestrone

UDP + 2-methoxyestrone beta-D-glucuronide

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 20-hydroxyeicosatetraenoic acid

UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 25-hydroxyergocalciferol

UDP + 25-hydroxyergocalciferol beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 3'-azido-3'-deoxythymidine

UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide

show the reaction diagram

-

isozymes UGT2B4, UGT2B7, and UGT2B17

-

-

?

UDP-glucuronate + 3'-azido-3'-deoxythymidine

UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 3,17-estradiol

UDP + 17-estradiol 3-O-glucuronide

show the reaction diagram

-

isozyme UGT1A1

-

-

?

UDP-glucuronate + 3,17-estradiol

UDP + 3-estradiol 17-O-glucuronide

show the reaction diagram

-

isozyme UGT1A1

-

-

?

UDP-glucuronate + 3,2'-dihydroxychalcone

UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 3-epideacetycinobufagin

UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone

UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide

show the reaction diagram

high activity

-

-

?

UDP-glucuronate + 4,2'-dihydroxychalcone

UDP + 4-hydroxychalcone 2'-O-beta-D-glucuronoside

show the reaction diagram

-

glucuronidation at the OH-2' position by UGT1A8, UGT1A1, and UGT1A3 isoforms. The A-ring OH-4 group promotes glucuronidation at the 2' position for the reaction of the exclusive substrate 4,2'-dihydroxychalcone of UGT1A1 and 1A3

-

-

?

UDP-glucuronate + 4-aminobiphenyl

?

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 4-ethylphenol

UDP + beta-D-glucuronosyl-(4-ethylphenol)

show the reaction diagram

show

UDP-glucuronate + 4-hydroxy-estrone

UDP + ?

show the reaction diagram

glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy

-

-

?

UDP-glucuronate + 4-hydroxyestradiol

UDP + 4-hydroxyestradiol beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 4-hydroxyretinoic acid

UDP + 4-hydroxyretinoic acid beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

mainly conjugated by UGT2B7

-

-

?

UDP-glucuronate + 4-methoxyestrone

UDP + 4-methoxyestrone beta-D-glucuronide

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferone beta-D-glucuronide

show the reaction diagram

show

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl-beta-D-glucuronide

show the reaction diagram

-

all isozymes, nonselective substrate

-

-

?

UDP-glucuronate + 4-methylumbelliferone

UDP + 4-methylumbelliferyl-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 4-methylumbelliferone

UDP + beta-D-glucuronosyl-(4-methylumbelliferone)

show the reaction diagram

show

UDP-glucuronate + 4-nitrophenol

UDP + 4-nitrophenol beta-D-glucuronide

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 4-nitrophenol

UDP + 4-nitrophenyl beta-D-glucuronide

show the reaction diagram

show

UDP-glucuronate + 4-nitrophenol

UDP + beta-D-glucuronosyl-(4-nitrophenol)

show the reaction diagram

show

UDP-glucuronate + 5-hydroxytryptophol

UDP + 5-hydroxy-tryptophol beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + 5-hydroxytryptophol

UDP + 5-hydroxytryptophol beta-D-glucuronide

show the reaction diagram

isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity

-

-

?

UDP-glucuronate + 5-hydroxytryptophol

UDP + 5-hydroxytryptophol beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6

-

-

?

UDP-glucuronate + 5alpha-dihydroaldosterone

UDP + 5alpha-dihydroaldosterone beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 5alpha-tetrahydrocortisone

UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 5beta-tetrahydrocortisone

UDP + 5beta-tetrahydrocortisone beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 6-gingerol

UDP + 6-gingerol 4'-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 6-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 6-hydroxymelatonin

UDP + 6-hydroxymelatonin beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 7-ethyl-10-hydroxy-camptothecin

UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

i.e. SN-38, an active metabolite of irinotecan

-

-

?

UDP-glucuronate + 7-ethyl-10-hydroxycampothecin

UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide

show the reaction diagram

i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9

-

-

?

UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin

UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside

show the reaction diagram

O60656, P16662, P22309, P22310

i.e. SN-38, an active metabolite of irinotecan

-

-

?

UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin

UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin

UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + 7-hydroxyflavanone

UDP + flavanone 7-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 8-gingerol

UDP + 6-gingerol 5-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 8-gingerol

UDP + 8-gingerol 4'-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 8-gingerol

UDP + 8-gingerol 5-O-beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + 8-hydroxyquinoline

UDP + 8-hydroxyquinoline beta-D-glucuronide

show the reaction diagram

O60656, P16662, P22309, P35503, P54855

-

-

-

?

UDP-glucuronate + acceptor

UDP + acceptor beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + acceptor

UDP + acceptor beta-glucuronoside

show the reaction diagram

show

UDP-glucuronate + aldosterone

UDP + aldosterone beta-D-glucuronide

show the reaction diagram

-

-

-

?

UDP-glucuronate + all-trans-retinoic acid

UDP + all-trans-retinoic acid beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

mainly conjugated by UGT2B7

-

-

?

UDP-glucuronate + Aloe-emodin

UDP + Aloe-emodin beta-D-glucuronide

show the reaction diagram

O60656, P22309, Q9HAW7, Q9HAW9

isozyme UGT1A7

-

-

?

UDP-glucuronate + alpinetin

UDP + alpinetin beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + amitriptyline

UDP + amitriptyline beta-D-glucuronoside

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + amitryptiline

UDP + amitryptiline beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + androstane-3,17-diol

UDP + androstane-3,17-diol 17-O-beta-D-glucuronide

show the reaction diagram

-

isozyme UGT2B15

-

-

?

UDP-glucuronate + androstane-3,17-diol

UDP + beta-D-glucuronosyl-androstane-3,17-diol

show the reaction diagram

show

UDP-glucuronate + androstanediol

UDP + androstanediol beta-D-glucuronoside

show the reaction diagram

O75310, O75795, P06133, P22309, P35504, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1

-

-

-

?

UDP-glucuronate + anthraflavic acid

UDP + anthraflavic acid 2-glucuronide

show the reaction diagram

-

isozyme UGT1A1

-

-

?

UDP-glucuronate + anthraflavic acid

UDP + anthraflavic acid 2-O-beta-D-glucuronide

show the reaction diagram

show

UDP-glucuronate + apigenin

UDP + apigenin beta-D-glucuronide

show the reaction diagram

show

UDP-glucuronate + asialo-orosomucoid

UDP + asialo-orosomucoid beta-D-glucuronide

show the reaction diagram

-

acceptor is a glycoprotein, preferred substrate

-

-

?

UDP-glucuronate + beta-estradiol

UDP + estradiol 3-beta-D-glucuronide

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + bilirubin

?

show the reaction diagram

-

-

-

-

?

UDP-glucuronate + bilirubin

UDP + bilirubin beta-D-glucuronoside

show the reaction diagram

show

UDP-glucuronate + biochanin A

UDP + biochanin A beta-D-glucuronide

show the reaction diagram

show

UDP-glucuronate + buprenorphine

UDP + buprenorphine glucuronide

show the reaction diagram

show

UDP-glucuronate + capsaicin

UDP + capsaicin beta-D-glucuronide