EC Number   |
General Information |
Reference |
|---|
   2.3.1.198 | evolution |
occurrence of land-plant-specific glycerol-3-phosphate acyltransferases is essential for cuticle formation and gametophore development in Physcomitrella patens, sn-2 GPATs harboring both domains by gene recombination are critical to cuticle formation of early land plants. Phylogenetic analysis |
757825 |
| 2.3.1.198 | malfunction |
a loss-of-function mutation in tomato SlGPAT6 results in increased susceptibility of leaves to Phytophthora infection, concomitant with changes in haustoria morphology. Modulation of GPAT6 expression alters the outer wall diameter of leaf epidermal cells. Tomato gpat6-a mutants have an impaired cell wall-cuticle continuum and fewer stomata, but show increased water loss |
757823 |
| 2.3.1.198 | malfunction |
glycerol content is strongly reduced in both stem and leaf cutin from all Arabidopsis thaliana mutants analyzed (gpat4/gpat8). Knocking out any of these genes individually, or as a pair (gpat4/gpat8), leads to large reductions in Arabidopsis thaliana cutin monomer loads, especially in the major monomer octadeca-6,9-diene-1,18-dioate (C18:2 DCA). sn-2-GPATs play pivotal roles in providing glycerol as a structural monomer for cutin through regiospecific sn-2 acylation of glycerol-3-phosphate. The double-knockout gpat4/gpat8 has an overall 60-70% reduction of aliphatic monomers in stem and leaf cutin, and the most pronounced decrease occurs in its major monomer, C18:2 dicarboxylic acyl-CoA (DCA) |
-, 757936 |
| 2.3.1.198 | malfunction |
GPAT6 mutant seeds show reduced germination rates and root lengths compared to wild-type in presence of 50-150 mM salt. Overexpression of glycerol-3-phosphate acyltransferase from Suaeda salsa improves salt tolerance in Arabidopsis thaliana deficient in GPAT6. In the seedling stage, chlorophyll content, the photochemical efficiency of PSII, PSI oxidoreductive activity (1I/Io), and the unsaturated fatty acid content of PG decrease less in overexpressing strains and more in mutant strains than that in wild-type under salt stress. The overexpression of SsGPAT alleviates the photoinhibition of PSII and PSI under salt stress by improving the unsaturated fatty acid content of phosphatidylglycerol (PG) |
-, 756821 |
| 2.3.1.198 | malfunction |
silencing of Nicotiana benthamiana NbGPAT6a increases leaf susceptibility to infection by the oomycetes Phytophthora infestans and Phytophthora palmivora, whereas overexpression of NbGPAT6a-GFP renders the leaves more resistant. Knockdown or knockout of GPAT6 renders leaves more susceptible to Phytophthora infection but more resistant to Bortrytis cinerea infection |
757823 |
| 2.3.1.198 | malfunction |
targeted disruption of PpGPAT2 delays growth and gametophore development. Disruption of PpGPAT2 causes increased susceptibility to osmotic and salt stresses in Physcomitrella patens |
757825 |
| 2.3.1.198 | malfunction |
the G163R mutation in gpat6-a confers a loss of SlGPAT6-mediated GPAT activity leading to P23F12 glossy mutant line with with abnormal fruit cutin amounts/compositions and increased fruit brightness. Loss of SlGPAT6 function leads to altered expression of genes involved in cuticle and cell wall formation and remodeling |
758037 |
| 2.3.1.198 | metabolism |
cutin biosynthesis involves the esterification of oxygenated 16- or 18-carbon fatty acids to glycerol through the action of glycerol-3-phosphate acyltransferases (GPAT4, GPAT6 and GPAT8). These enzymes have specificity for the second carbon of the glycerol (sn-2 position) |
757823 |
| 2.3.1.198 | metabolism |
isozymes GPAT4 and GPAT8 are glycerol-3-phosphate 2-O acyltransferases that catalyze the first step in leaf and stem cutin acylglycerol assembly |
-, 757936 |
| 2.3.1.198 | more |
constitutive expression of NbGPAT6a renders leaves resistant to Phytophthora infection, NbGPAT6-mediated resistance is associated with longer-term leaf development processes. Modulating GPAT6 expression alters the thickness of the outer cell walls of the leaf epidermis |
757823 |
