EC Number   |
General Information |
Reference |
|---|
    2.1.1.37 | malfunction |
DNMT1 is crucial for cell survival, as in its absence cells undergo arrest in G1/S, a DNA damage response is triggered, and the cells undergo mitotic catastrophe |
705915 |
| 2.1.1.37 | metabolism |
both DNMT3A and DNMT3B are involved in de novo DNA methylation |
703146 |
| 2.1.1.37 | physiological function |
BPDE recruits DNMT3A to methylate the RAR-beta2 gene promoter and thus silence its gene expression, which in turn, may contribute to the malignant transformation of esophageal epithelial cells |
720441 |
| 2.1.1.37 | physiological function |
DCM knockout cells overexpress the drug resistance transporter SugE, linked to ethidium bromide resistance. SugE expression also increases in the presence of the DNA methylation inhibitor 5-azacytidine. The effect of Dcm on sugE expression is primarily restricted to early stationary phase, and RpoS is required for robust sugE expression. Dcm knockout cells are more resistant to ethidium bromide than wild-type cells, and complementation with a plasmid-borne dcm gene restores ethidium bromide sensitivity. SugE knockout cells are more sensitive to ethidium bromide than wild-type cells |
733884 |
| 2.1.1.37 | physiological function |
DNA methylation at cytosine residues in CpG dinucleotides is a component of epigenetic marks crucial to mammalian development, maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1 |
703364 |
| 2.1.1.37 | physiological function |
DNA methylation may play a dynamic physiological role in the adult brain, possibly, the DNA methylation pattern is undergoing constant remodeling and requires the presence of DNA methyltransferases to allow adaptation at the level of the DNA methylation pattern in response to environmental cues |
705915 |
| 2.1.1.37 | physiological function |
DNMT1 cytosine methyltransferase governs maintenance methylation in mammals, rearrangements of non-DMD, but not DMD methylation in preimplantation embryos |
706526 |
| 2.1.1.37 | physiological function |
Dnmt1 is involved in DNA methylation pattern regulation during the late stage oocyte differentiation, maturation and early embryonic development, overview |
703545 |
| 2.1.1.37 | physiological function |
DNMT1 is required to maintain global methylation after DNA replication has taken place |
703987 |
| 2.1.1.37 | physiological function |
DNMT2 controls retrotransposon silencing and telomere integrity in somatic cells, significant DNMT2-dependent DNA methylation occurs during early embryogenesis, overview |
705852 |
