Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Rattus norvegicus | DNMT1 is crucial for cell survival | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hippocampus | different levels of global methylation in the adult rat dentate gyrus and CA1 region in comparison with the CA2 and CA3 regions. mRNA levels of DNA methyltransferases exhibit similar regional specificity and are correlated with global DNA methylation levels | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Rattus norvegicus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | DNMT1 is crucial for cell survival | Rattus norvegicus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | DNMT1 is crucial for cell survival, as in its absence cells undergo arrest in G1/S, a DNA damage response is triggered, and the cells undergo mitotic catastrophe | Rattus norvegicus |
physiological function | DNA methylation may play a dynamic physiological role in the adult brain, possibly, the DNA methylation pattern is undergoing constant remodeling and requires the presence of DNA methyltransferases to allow adaptation at the level of the DNA methylation pattern in response to environmental cues | Rattus norvegicus |