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Literature summary for 2.1.1.37 extracted from

  • Brown, S.E.; Weaver, I.C.; Meaney, M.J.; Szyf, M.
    Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus (2008), Neurosci. Lett., 440, 49-53.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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Rattus norvegicus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Rattus norvegicus DNMT1 is crucial for cell survival DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Rattus norvegicus
-
hippocampus different levels of global methylation in the adult rat dentate gyrus and CA1 region in comparison with the CA2 and CA3 regions. mRNA levels of DNA methyltransferases exhibit similar regional specificity and are correlated with global DNA methylation levels Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
Rattus norvegicus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?
DNA + S-adenosyl-L-methionine DNMT1 is crucial for cell survival Rattus norvegicus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction DNMT1 is crucial for cell survival, as in its absence cells undergo arrest in G1/S, a DNA damage response is triggered, and the cells undergo mitotic catastrophe Rattus norvegicus
physiological function DNA methylation may play a dynamic physiological role in the adult brain, possibly, the DNA methylation pattern is undergoing constant remodeling and requires the presence of DNA methyltransferases to allow adaptation at the level of the DNA methylation pattern in response to environmental cues Rattus norvegicus